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GENE：NUBP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NUBP1
FullNmae NUBP iron-sulfur cluster assembly factor 1, cytosolic
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8041
EnsembleID ENSG00000103274
Uniprot P53384

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NUBP1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NUBP1 cuproptosis 36313717 Proteins carrying iron-sulfur clusters are essential for the basic metabolism of all organisms. Eukaryotic iron-sulfur cluster assembly includes direct mitochondrial iron-sulfur cluster (ISC) co-assembly pathway and cytosolic iron-sulfur cluster assembly (CIA) pathway that uses active sulfur as substrate, these pathways containing protein complex (composed of cysteine desulfurase, a scaffold protein, auxiliary ISD11 protein, acyl carrier protein, frataxin, and ferredoxin), the related genes (including NFS1, ISD11, ACP1, ISCU2, FXN, FDX2, FDXR) and proteins of cytokine induced apoptosis inhibitor 1 (CIAPIN1), novel diflavin oxidoreductase 1 (NDOR1), nucleotide binding protein 2 (NUBP2), nucleotide binding protein 1 (NUBP1), iron-only hydrogenase-like protein 1 (IOP1), and Cytosolic iron-Sulfur assembly component 1 (CIAO1) Proteins carrying iron-sulfur cluster
NUBP1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins

Go Annotation:

GeneSymbol Go id
NUBP1 GO:0000166,GO:0001558,GO:0005515,GO:0005524,GO:0005634,GO:0005814,GO:0005829,GO:0005829,GO:0005886,GO:0005929,GO:0006879,GO:0010826,GO:0016226,GO:0016226,GO:0016887,GO:0030030,GO:0046872,GO:0051536,GO:0051536,GO:0051539,GO:0051642,GO:0072697,GO:0140663

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 NUBP1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NUBP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NUBP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NUBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NUBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NUBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NUBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NUBP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 NUBP1 17242205 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 NUBP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 NUBP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 NUBP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004719AB NUBP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED NUBP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 NUBP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000939AF NUBP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A NUBP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E NUBP1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SPRY2 NUBP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HK2 NUBP1 25348397 N/A physical interaction ComPPI
PDLIM1 NUBP1 25348397 N/A physical interaction ComPPI
NDN NUBP1 10915798 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NUBP1 DFFB 25348397 N/A physical interaction ComPPI
NUBP1 NOL3 25348397 N/A physical interaction ComPPI
NUBP1 EHD1 25348397 N/A physical interaction ComPPI
NUBP1 STK39 25348397 N/A physical interaction ComPPI
NUBP1 UBQLN1 25348397 N/A physical interaction ComPPI
NUBP1 AIMP1 25348397 N/A physical interaction ComPPI
ARIH2 NUBP1 25348397 N/A physical interaction ComPPI

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