GENE：MCU
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MCU |
| FullNmae | mitochondrial calcium uniporter |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:23526 |
| EnsembleID | ENSG00000156026 |
| Uniprot | Q8NE86 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MCU | mpt | 31097542 | We found that SPG7 directs the m-AAA complex to favor association with the mitochondrial Ca2+ uniporter (MCU) and MCU processing regulates higher order MCU-complex formation. The results suggest that SPG7 does not constitute a core component of the mPTP but can modulate mPTP through regulation of the basal mitochondrial Ca2+ concentration. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MCU | GO:0005262,GO:0005262,GO:0005262,GO:0005515,GO:0005739,GO:0005743,GO:0005743,GO:0005743,GO:0006851,GO:0006851,GO:0015292,GO:0015292,GO:0015292,GO:0019722,GO:0032024,GO:0034704,GO:0034704,GO:0036444,GO:0036444,GO:0036444,GO:0036444,GO:0042593,GO:0051259,GO:0051560,GO:0051560,GO:0051560,GO:0051561,GO:0051561,GO:0090023,GO:0090141,GO:1990246,GO:1990246,GO:1990246,GO:1990246,GO:1990246 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MCU | hsa:90550 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| MCU | hsa:90550 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MCU | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MCU | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MCU | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | MCU | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | MCU | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MCU | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000016D2D4 | MCU | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001CC864 | MCU | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002F3336 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000239117 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0874 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000083D87 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000022B729 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CEB74 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000204177 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CE046 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | MCU | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023BE29 | MCU | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | MCU | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | MCU | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EIF2B2 | MCU | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| VAPA | MCU | 25348397 | N/A | physical interaction | ComPPI |
| RAB7A | MCU | 25348397 | N/A | physical interaction | ComPPI |
| MYC | MCU | 25348397 | N/A | physical interaction | ComPPI |
| ATXN3 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| PDCD1 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| EIF2B1 | MCU | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| ELAVL1 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| GNAI2 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| ASPH | MCU | 25348397 | N/A | physical interaction | ComPPI |
| EIF2B4 | MCU | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLC38A2 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| TOR1AIP2 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| IL13RA2 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A5 | MCU | 25348397 | N/A | physical interaction | ComPPI |
| NDUFA9 | MCU | 24234451 24344204 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MCU | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| MCU | GOLT1B | 25348397 | N/A | physical interaction | ComPPI |
| MCU | NDUFA4 | 25348397 | N/A | physical interaction | ComPPI |
| MCU | SLC15A1 | 25348397 | N/A | physical interaction | ComPPI |