Gene Information gene info

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GENE：CUTC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CUTC
FullNmae cutC copper transporter
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24271
EnsembleID ENSG00000119929
Uniprot Q9NTM9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CUTC mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CUTC cuproptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CUTC cuproptosis 38408075 We retrieved 21 genes involved in Cuproptosis from the literature, including CDKN2A, DLD, DLAT, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, and PDHB, ATB7B, CUTC, GRX1, MT1A, MT2A, MT3, XIAP, ATM, PRNP, P53, and SP1. genes involved in Cuproptosis
CUTC cuproptosis 38408075 ATP7B and GRX1 excrete excess copper ions out of the mitochondria. CUTC directly binds Cu2+ while XIAP passivates and hydrolyzes caspase after binding Cu2+ to inhibit Cuproptosis. Inhibitor
CUTC cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.38 database.
CUTC cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway

Go Annotation:

GeneSymbol Go id
CUTC GO:0005507,GO:0005507,GO:0005507,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006825,GO:0051262,GO:0055070

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL6 CUTC 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR CUTC 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CUTC 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CUTC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CUTC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CUTC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CUTC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CUTC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CUTC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PIM2 CUTC 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
ATXN1 CUTC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SLC25A6 CUTC 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
XPO7 CUTC 24234451 25348397 29748336 physical association anti tag coimmunoprecipitation ComPPI,IntAct
CUTC NUDT18 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
CUTC NIF3L1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach ComPPI,IntAct
CUTC SPG21 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CUTC NADSYN1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CUTC LNX1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
CUTC SLC27A6 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CUTC ASCC2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CUTC GABPA 25348397 N/A physical interaction ComPPI
CUTC GANAB 25348397 N/A physical interaction ComPPI
CUTC LIMCH1 25348397 N/A physical interaction ComPPI
CUTC IRF2BP2 25348397 N/A physical interaction ComPPI
CUTC PRRC1 25348397 N/A physical interaction ComPPI
CUTC BCL6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CUTC SDCBP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CUTC CEP76 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CUTC TRIM25 25348397 N/A physical interaction ComPPI
CUTC MESD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUTC CDC37 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUTC PICK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUTC KANK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUTC NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUTC CUTC 14525934 16169070 16189514 24234451 25416956 physical association two hybrid array,two hybrid pooling approach,two hybrid HPRD,IntAct

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