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GENE：BLOC1S2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BLOC1S2
FullNmae biogenesis of lysosomal organelles complex 1 subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20984
EnsembleID ENSG00000196072
Uniprot Q6QNY1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BLOC1S2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BLOC1S2 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
BLOC1S2 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BLOC1S2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BLOC1S2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BLOC1S2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BLOC1S2 GO:0000930,GO:0000930,GO:0005515,GO:0005739,GO:0005829,GO:0008089,GO:0008625,GO:0016197,GO:0031083,GO:0031083,GO:0031083,GO:0031175,GO:0032418,GO:0032418,GO:0032418,GO:0032438,GO:0043015,GO:0043015,GO:0048490,GO:0051036,GO:0060155,GO:0062196,GO:0072384,GO:0097345,GO:0098574,GO:0099078,GO:0099078,GO:0099078,GO:1904115

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP BLOC1S2 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR BLOC1S2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 BLOC1S2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 BLOC1S2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 BLOC1S2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 BLOC1S2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BLOC1S2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BLOC1S2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BLOC1S2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000183BED BLOC1S2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA BLOC1S2 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 BLOC1S2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 BLOC1S2 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BLOC1S2 SNAPIN 25361965 interaction type N/A PTMCode2
SNAPIN BLOC1S2 25361965 interaction type N/A PTMCode2
IFT57 BLOC1S2 25361965 interaction type N/A PTMCode2
BLOC1S2 IFT57 25361965 interaction type N/A PTMCode2
DTNBP1 BLOC1S2 25361965 interaction type N/A PTMCode2
BLOC1S2 DTNBP1 25361965 interaction type N/A PTMCode2
BLOC1S3 BLOC1S2 25361965 interaction type N/A PTMCode2
BLOC1S2 BLOC1S3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GEM BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WASHC3 BLOC1S2 25348397 N/A physical interaction ComPPI
ERP27 BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BFSP2 BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOC8 BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BORCS6 BLOC1S2 25348397 N/A physical interaction ComPPI
PICK1 BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S4 BLOC1S2 14525934 15102850 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOC1 BLOC1S2 25348397 N/A physical interaction ComPPI
SNAPIN BLOC1S2 14525934 15102850 22203680 23414517 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,molecular sieving,pull down,physical interaction,two hybrid array,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SCOC BLOC1S2 25348397 N/A physical interaction ComPPI
TNNT1 BLOC1S2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARFIP2 BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DTNBP1 BLOC1S2 15102850 22203680 24234451 25348397 association,physical association coimmunoprecipitation,molecular sieving,pull down,physical interaction ComPPI,IntAct
BLOC1S1 BLOC1S2 15102850 22203680 24234451 25348397 physical association two hybrid,coimmunoprecipitation,electron microscopy,physical interaction ComPPI,IntAct
BLOC1S5 BLOC1S2 14525934 15102850 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
BLOC1S2 BLOC1S3 14525934 15102850 24234451 25348397 physical association two hybrid,coimmunoprecipitation,physical interaction,two hybrid ComPPI,HPRD,IntAct
BLOC1S2 BLOC1S6 14525934 15102850 22203680 24234451 25348397 association,physical association coimmunoprecipitation,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
BLOC1S2 OSBPL9 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLOC1S2 HMOX2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLOC1S2 MEST 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLOC1S2 RDH11 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLOC1S2 C8ORF33 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLOC1S2 APP 25348397 N/A physical interaction ComPPI
BLOC1S2 WASHC1 25348397 N/A physical interaction ComPPI
BLOC1S2 FAM9B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BLOC1S2 TEX35 25348397 N/A physical interaction ComPPI
BLOC1S2 SNX7 25348397 N/A physical interaction ComPPI
BLOC1S2 BCAS4 25348397 N/A physical interaction ComPPI
BLOC1S2 TRIM69 25348397 N/A physical interaction ComPPI
BLOC1S2 TSKS 25348397 N/A physical interaction ComPPI
BLOC1S2 SYBU 25348397 N/A physical interaction ComPPI
BLOC1S2 COG6 25348397 N/A physical interaction ComPPI
BLOC1S2 TRIML2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 IKBIP 25348397 N/A physical interaction ComPPI
BLOC1S2 TRAF3IP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BLOC1S2 IFT20 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BLOC1S2 IFT57 18188704 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
BLOC1S2 DCTN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 CCNC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 CCDC146 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 P4HA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 SSC5D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 SH2D4A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 KRT26 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLOC1S2 FAM161B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAM16 BLOC1S2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLOC1S2 BLOC1S2 15102850 24234451 physical association coimmunoprecipitation IntAct

Visualization










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