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GENE：MICU2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MICU2
FullNmae mitochondrial calcium uptake 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:31830
EnsembleID ENSG00000165487
Uniprot Q8IYU8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MICU2 mpt 33041854 The mitochondrial calcium uniporter complex through which calcium enters the mitochondria is composed of several proteins, including the pore-forming subunit MCU and its regulators MCUR1, MICU1, and MICU2. Mitochondrial calcium overload leads to opening of MPTP (mitochondrial permeability transition pore) and results in apoptotic cell death. retulator signature

Go Annotation:

GeneSymbol Go id
MICU2 GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0005743,GO:0005743,GO:0005758,GO:0006851,GO:0034704,GO:0036444,GO:0036444,GO:0036444,GO:0036444,GO:0046982,GO:0051560,GO:0051560,GO:0051560,GO:0051560,GO:0051561,GO:0051562,GO:1990246,GO:1990246,GO:1990246,GO:1990246

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MICU2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MICU2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C MICU2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MICU2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 MICU2 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TUBB MICU2 25348397 N/A physical interaction ComPPI
CSNK1D MICU2 25348397 N/A physical interaction ComPPI
JUN MICU2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 MICU2 25348397 N/A physical interaction ComPPI
PON1 MICU2 25348397 N/A physical interaction ComPPI
CDH5 MICU2 25348397 N/A physical interaction ComPPI
CSNK1E MICU2 25348397 N/A physical interaction ComPPI
ASH2L MICU2 25348397 N/A physical interaction ComPPI
SQSTM1 MICU2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
MBP MICU2 11124993 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ATG7 MICU2 25348397 N/A physical interaction ComPPI
SMAP1 MICU2 25348397 N/A physical interaction ComPPI
AIFM1 MICU2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GAPVD1 MICU2 25348397 N/A physical interaction ComPPI
DCAF11 MICU2 25348397 N/A physical interaction ComPPI
MICU2 KLHL22 25348397 N/A physical interaction ComPPI
MICU2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MICU2 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRIM44 MICU2 25348397 N/A physical interaction ComPPI

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