Gene Information gene info

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GENE：RHOT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RHOT1
FullNmae ras homolog family member T1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21168
EnsembleID ENSG00000126858
Uniprot Q8IXI2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RHOT1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RHOT1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RHOT1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RHOT1 GO:0003674,GO:0003924,GO:0005509,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0007005,GO:0007015,GO:0007165,GO:0007264,GO:0010821,GO:0016020,GO:0019725,GO:0047497,GO:0047497,GO:0097345

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RHOT1 hsa:55288 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRAK1 RHOT1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR RHOT1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RHOT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RHOT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RHOT1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RHOT1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 RHOT1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RHOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171CD1 RHOT1 18362358 rna interference,inhibition array technology miRSponge
URS0000171CD1 RHOT1 18362358 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 RHOT1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D RHOT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000023BE29 RHOT1 24158791 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PINK1 RHOT1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PTPN18 RHOT1 25348397 N/A physical interaction ComPPI
RHOT2 RHOT1 25348397 N/A physical interaction ComPPI
PEX19 RHOT1 25348397 N/A physical interaction ComPPI
UBB RHOT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC RHOT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A RHOT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 RHOT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
NTRK1 RHOT1 25348397 N/A physical interaction ComPPI
ILK RHOT1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CFTR RHOT1 25348397 N/A physical interaction ComPPI
IRAK1 RHOT1 25348397 N/A physical interaction ComPPI
PRKN RHOT1 22078885 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAK2 RHOT1 25348397 N/A physical interaction ComPPI
TRAK1 RHOT1 16630562 19135897 24234451 24995978 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
KIF5C RHOT1 19135897 24234451 25348397 physical association anti tag coimmunoprecipitation,cosedimentation in solution ComPPI,IntAct
AMFR RHOT1 25348397 N/A physical interaction ComPPI
CDK20 RHOT1 25348397 N/A physical interaction ComPPI
ATP5F1A RHOT1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
COQ9 RHOT1 25348397 N/A physical interaction ComPPI
PCSK9 RHOT1 25348397 N/A physical interaction ComPPI
NXF1 RHOT1 25348397 N/A physical interaction ComPPI
COX6B1 RHOT1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
E2F3 RHOT1 22157815 24234451 25348397 association pull down ComPPI,IntAct
PINK1 RHOT1 22078885 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERLIN2 RHOT1 21343306 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RHOT1 APOOL 25348397 N/A physical interaction ComPPI
HSCB RHOT1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
PINK1 RHOT1 22078885 22396657 24671417 27898060 inhibition N/A OmniPath
IRAK1 RHOT1 21903422 27898060 N/A N/A OmniPath

Visualization










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