GENE：SLC8A3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC8A3 |
| FullNmae | solute carrier family 8 member A3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11070 |
| EnsembleID | ENSG00000100678 |
| Uniprot | P57103 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC8A3 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC8A3 | GO:0002244,GO:0005432,GO:0005432,GO:0005432,GO:0005516,GO:0005741,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0006811,GO:0006851,GO:0006874,GO:0007154,GO:0007611,GO:0007612,GO:0007613,GO:0014069,GO:0014819,GO:0016528,GO:0030424,GO:0030424,GO:0030425,GO:0031594,GO:0035725,GO:0035725,GO:0042383,GO:0042383,GO:0042552,GO:0043025,GO:0043197,GO:0043204,GO:0043679,GO:0045202,GO:0045202,GO:0046872,GO:0048471,GO:0048709,GO:0050808,GO:0051560,GO:0060291,GO:0070161,GO:0070588,GO:0071456,GO:0071901,GO:0098703,GO:0098794,GO:0098815,GO:0099580,GO:1903779 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC8A3 | hsa:6547 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04740 | Olfactory transduction - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| SLC8A3 | hsa:6547 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HIF1A | SLC8A3 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | SLC8A3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SLC8A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KCNIP3 | SLC8A3 | 16306395 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000036AFF1 | SLC8A3 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000331800 | SLC8A3 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | SLC8A3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | SLC8A3 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YWHAB | SLC8A3 | 14525934 16679322 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| YWHAQ | SLC8A3 | 14525934 16679322 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| YWHAE | SLC8A3 | 14525934 16679322 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PPP3CB | SLC8A3 | 25348397 | N/A | in vivo | ComPPI |
| SLC8A3 | PDE3B | 25348397 | N/A | physical interaction | ComPPI |