GENE：ACE2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACE2 |
| FullNmae | angiotensin converting enzyme 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:13557 |
| EnsembleID | ENSG00000130234 |
| Uniprot | Q9BYF1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACE2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACE2 | GO:0001618,GO:0001618,GO:0001817,GO:0002003,GO:0002003,GO:0003051,GO:0003081,GO:0003081,GO:0004175,GO:0004180,GO:0004181,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005886,GO:0005886,GO:0005886,GO:0005929,GO:0008237,GO:0008237,GO:0008241,GO:0008270,GO:0009986,GO:0015827,GO:0016020,GO:0016324,GO:0019058,GO:0019065,GO:0019229,GO:0022898,GO:0030666,GO:0031526,GO:0042127,GO:0042802,GO:0045121,GO:0046718,GO:0046718,GO:0046718,GO:0046813,GO:0046813,GO:0048662,GO:0050727,GO:0051957,GO:0060135,GO:0060452,GO:0061025,GO:0070062,GO:0070373,GO:0097746,GO:0098670,GO:1903598,GO:1903779,GO:1905737,GO:2000272,GO:2000379 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACE2 | hsa:59272 | path:hsa04614 | Renin-angiotensin system - Homo sapiens (human) |
| ACE2 | hsa:59272 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| ACE2 | hsa:59272 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | ACE2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ACE2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ACE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ACE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ACE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ACE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ACE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | ACE2 | 19592460 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CALM1 | ACE2 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| ACE2 | GHRL | 11815627 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ACE2 | AGT | 10969042 11815627 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| ACE2 | AAMP | 25348397 | N/A | physical interaction | ComPPI |
| ACE2 | CAT | 25348397 | N/A | physical interaction | ComPPI |
| ACE2 | ISYNA1 | 25348397 | N/A | physical interaction | ComPPI |
| ACE2 | NTS | 11815627 14525934 | N/A | experimental interaction detection | HPRD |
| ACE2 | CALM2 | 18070603 24234451 | physical association | anti bait coimmunoprecipitation | IntAct |
| XPO1 | ACE2 | 11027275 18076379 18715118 27898060 | N/A | N/A | OmniPath |
| CDK1 | ACE2 | 21658602 24493588 25049391 27898060 | N/A | N/A | OmniPath |