GENE：ADM
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ADM |
| FullNmae | adrenomedullin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:259 |
| EnsembleID | ENSG00000148926 |
| Uniprot | P35318 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ADM | immunogenic | 26998143 | Combining ADM, which can induce immunogenic cell death, with DCs enhanced the systemic immune response. | retulator signature |
| ADM | ferroptosis | 37688783 | VDR inhibits ox-LDL-induced endothelial dysfunction and ferroptosis by regulating ADM transcription and acting on AMPK signaling pathway. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ADM | GO:0001570,GO:0001666,GO:0001843,GO:0002026,GO:0002031,GO:0003073,GO:0003073,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0006954,GO:0007165,GO:0007189,GO:0007189,GO:0007189,GO:0007204,GO:0007507,GO:0007565,GO:0008209,GO:0008284,GO:0008285,GO:0010460,GO:0010460,GO:0019933,GO:0031100,GO:0031102,GO:0031623,GO:0031700,GO:0031700,GO:0032496,GO:0032868,GO:0035809,GO:0042475,GO:0042594,GO:0043065,GO:0043116,GO:0045766,GO:0045906,GO:0048589,GO:0051384,GO:0060670,GO:0097084,GO:0097647,GO:1990410,GO:1990410,GO:2000184,GO:2001214 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ADM | hsa:133 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| ADM | hsa:133 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ADM | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ADM | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | ADM | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ADM | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2A | ADM | 10848972 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | ADM | 12630823 9480831 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GTF3A | ADM | 12630823 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | ADM | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00001D69F6 | ADM | 24037526 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000013E79D | ADM | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000007340 | ADM | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BD367 | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D6C3F | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058BB84 | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D1FC | ADM | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AF715 | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000049704B | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070B1D | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000243FF1 | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FA076 | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C36BD | ADM | 20371350 21572407 22012620 23446348 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | ADM | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0B46 | ADM | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076E54 | ADM | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F9738 | ADM | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | ADM | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006B702 | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000254A6 | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031B6ED | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E2232 | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000140295 | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E1A16 | ADM | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E96DA | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CC005 | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CAE0C | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5BAA | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EE123 | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052EA98 | ADM | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EDN1 | ADM | 11410113 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| DPYS | ADM | 25348397 | N/A | physical interaction | ComPPI |
| MME | ADM | 14525934 25348397 27898060 8687431 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CALCRL | ADM | 14525934 25348397 9620797 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CFH | ADM | 11116141 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| ADM | ADM | 14525934 9620797 | N/A | experimental interaction detection | HPRD |
| ADM | CALCR | 12565884 15692146 27898060 | N/A | N/A | OmniPath |
| ADM | MRGPRX2 | 15823563 27898060 | stimulant | N/A | OmniPath |
| ADM | GPR182 | 27898060 7592696 | stimulant | N/A | OmniPath |
| ADM | RAMP2 | 27898060 9620797 | stimulant | N/A | OmniPath |