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GENE：ADSL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADSL
FullNmae adenylosuccinate lyase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:291
EnsembleID ENSG00000239900
Uniprot P30566

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADSL pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ADSL immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADSL GO:0001666,GO:0004018,GO:0004018,GO:0005829,GO:0005829,GO:0005829,GO:0006164,GO:0006167,GO:0006177,GO:0006189,GO:0007584,GO:0009060,GO:0014850,GO:0032991,GO:0042594,GO:0042802,GO:0044208,GO:0044208,GO:0044209,GO:0070626,GO:0070626,GO:0097294

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ADSL hsa:158 path:hsa00230 Purine metabolism - Homo sapiens (human)
ADSL hsa:158 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
ADSL hsa:158 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ADSL hsa:158 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
ADSL hsa:158 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ADSL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ADSL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ADSL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ADSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ADSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ADSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 ADSL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 ADSL 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 ADSL 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000030F801 ADSL 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 ADSL 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ADSL 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ADSL ADK 25361965 interaction type N/A PTMCode2
ADK ADSL 25361965 interaction type N/A PTMCode2
ADSL APRT 25361965 interaction type N/A PTMCode2
APRT ADSL 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TEKT4 ADSL 25348397 N/A physical interaction ComPPI
CEP43 ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
OXSR1 ADSL 25348397 N/A physical interaction ComPPI
LDHB ADSL 25348397 N/A physical interaction ComPPI
KEAP1 ADSL 25348397 N/A physical interaction ComPPI
MCM2 ADSL 25348397 N/A physical interaction ComPPI
REL ADSL 25348397 N/A physical interaction ComPPI
CCN3 ADSL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
JUN ADSL 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2I ADSL 25348397 N/A physical interaction ComPPI
UBC ADSL 25348397 N/A physical interaction ComPPI
NTRK1 ADSL 25348397 N/A physical interaction ComPPI
CEP135 ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
USP4 ADSL 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBQLN2 ADSL 25348397 N/A physical interaction ComPPI
RPE ADSL 25348397 N/A physical interaction ComPPI
SAE1 ADSL 25348397 N/A physical interaction ComPPI
TPI1 ADSL 25348397 N/A physical interaction ComPPI
ALOX5 ADSL 25348397 N/A physical interaction ComPPI
GTF2E2 ADSL 25348397 N/A physical interaction ComPPI
SSX2IP ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CENPJ ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAD23B ADSL 25348397 N/A physical interaction ComPPI
EIF1AX ADSL 25348397 N/A physical interaction ComPPI
FGB ADSL 25348397 N/A physical interaction ComPPI
PLIN3 ADSL 25348397 N/A physical interaction ComPPI
NFKB1 ADSL 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
TRIM25 ADSL 25348397 N/A physical interaction ComPPI
TWF1 ADSL 25348397 N/A physical interaction ComPPI
DNAJB1 ADSL 25348397 N/A physical interaction ComPPI
SOD1 ADSL 25348397 N/A physical interaction ComPPI
PAIP1 ADSL 25348397 N/A physical interaction ComPPI
CALCOCO2 ADSL 25348397 N/A physical interaction ComPPI
CEP152 ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CNTROB ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NPLOC4 ADSL 25348397 N/A physical interaction ComPPI
MTMR7 ADSL 25348397 N/A physical interaction ComPPI
USP47 ADSL 25348397 N/A physical interaction ComPPI
KLHL20 ADSL 25348397 N/A physical interaction ComPPI
MED4 ADSL 25348397 N/A physical interaction ComPPI
CTSC ADSL 25348397 N/A physical interaction ComPPI
WDR4 ADSL 25348397 N/A physical interaction ComPPI
WARS1 ADSL 25348397 N/A physical interaction ComPPI
RPGRIP1 ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PAICS ADSL 25348397 N/A physical interaction ComPPI
NT5C2 ADSL 25348397 N/A physical interaction ComPPI
DRG2 ADSL 25348397 N/A physical interaction ComPPI
CRIP1 ADSL 25348397 N/A physical interaction ComPPI
OFD1 ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
XPNPEP1 ADSL 25348397 N/A physical interaction ComPPI
API5 ADSL 25348397 N/A physical interaction ComPPI
ABAT ADSL 25348397 N/A physical interaction ComPPI
G3BP2 ADSL 25348397 N/A physical interaction ComPPI
FBF1 ADSL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NXF1 ADSL 25348397 N/A physical interaction ComPPI
PFAS ADSL 25348397 N/A physical interaction ComPPI
ATIC ADSL 25348397 N/A physical interaction ComPPI
USP15 ADSL 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GART ADSL 25348397 N/A physical interaction ComPPI
EHD4 ADSL 25348397 N/A physical interaction ComPPI
G3BP1 ADSL 25348397 N/A physical interaction ComPPI
OTUB1 ADSL 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ADSL PDE12 25348397 N/A physical interaction ComPPI
ADSL BTF3L4 25348397 N/A physical interaction ComPPI
ADSL TEKT2 25348397 N/A physical interaction ComPPI
ADSL GPT2 25348397 N/A physical interaction ComPPI
ADSL ALDH8A1 25348397 N/A physical interaction ComPPI
ADSL CEP104 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ADSL CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ADSL CEP89 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SNRNP27 ADSL 25348397 N/A physical interaction ComPPI
DDA1 ADSL 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYMS ADSL 25348397 N/A physical interaction ComPPI
COMTD1 ADSL 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009BBA3F ADSL 27087310 direct interaction,inhibition N/A NPInter

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