GENE：ANGPT2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ANGPT2 |
| FullNmae | angiopoietin 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:485 |
| EnsembleID | ENSG00000091879 |
| Uniprot | O15123 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ANGPT2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ANGPT2 | GO:0001525,GO:0001666,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0007165,GO:0007281,GO:0009612,GO:0009749,GO:0010467,GO:0010812,GO:0014070,GO:0014823,GO:0016525,GO:0030971,GO:0030971,GO:0031100,GO:0042995,GO:0043537,GO:0045766,GO:0046872,GO:0048014,GO:0048014,GO:0050928,GO:0060135,GO:0062023,GO:0071363,GO:0072012 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ANGPT2 | hsa:285 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| ANGPT2 | hsa:285 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| ANGPT2 | hsa:285 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| ANGPT2 | hsa:285 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| ANGPT2 | hsa:285 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| ANGPT2 | hsa:285 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | ANGPT2 | 15003510 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| GATA1 | ANGPT2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ANGPT2 | 18971253 19941826 22792348 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ANGPT2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | ANGPT2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ANGPT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ANGPT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ANGPT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ANGPT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ANGPT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | ANGPT2 | 15003510 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXC2 | ANGPT2 | 20213583 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXO1 | ANGPT2 | 20213583 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LMO2 | ANGPT2 | 22792348 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LYL1 | ANGPT2 | 22792348 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ANGPT2 | 22792348 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VHL | ANGPT2 | 12434420 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004F4657 | ANGPT2 | 24384875 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004F859B | ANGPT2 | 24403060 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDKN1A | ANGPT2 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| LYN | ANGPT2 | 25348397 | N/A | physical interaction | ComPPI |
| VEGFA | ANGPT2 | 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI |
| ITGB1 | ANGPT2 | 25348397 | N/A | physical interaction | ComPPI |
| ITGAV | ANGPT2 | 25348397 | N/A | physical interaction | ComPPI |
| ANGPT1 | ANGPT2 | 14525934 25348397 9204896 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| ANGPT2 | TEK | 14525934 20708158 24234451 25348397 9723709 | N/A | cosedimentation in solution,dynamic light scattering,experimental interaction detection,molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay | ComPPI,HPRD,IntAct |
| ANGPT2 | CSNK2B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ANGPT2 | ANXA7 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ANGPT2 | IQCB1 | 21565611 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ANGPT2 | ITGA5 | 25348397 | N/A | physical interaction | ComPPI |
| ANGPT2 | ZZEF1 | 25348397 | N/A | physical interaction | ComPPI |
| ANGPT2 | FBXO28 | 25348397 | N/A | physical interaction | ComPPI |
| ANGPT2 | HECTD3 | 25348397 | N/A | physical interaction | ComPPI |
| ANGPT2 | ANGPT2 | 10514510 14525934 15769741 | N/A | experimental interaction detection | HPRD |
| VIM | ANGPT2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| ANGPT2 | TEK | 12427764 15893672 16732286 20708158 27898060 9204896 9723709 | stimulant | N/A | OmniPath |