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GENE：ANXA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ANXA1
FullNmae annexin A1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:533
EnsembleID ENSG00000135046
Uniprot P04083

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ANXA1 pyroptosis 39773706 We found that Ac2-26/OGP/GPPG can effectively reduce ROS, mitigates macrophage pyroptosis via the ANXA1/NLRP3/Caspase-1/GSDMD pathway and enhanced osteogenic differentiation. retulator signature
ANXA1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ANXA1 immunogenic 31727257 In the context of immunogenic cell death (ICD), ANXA1 is released from the cytoplasm of dying cells and, once extracellular, acts on formyl peptide receptor 1 (FPR1) expressed on dendritic cells to favor long-term interactions between dying and dendritic cells. retulator signature
ANXA1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ANXA1 GO:0001533,GO:0001780,GO:0001891,GO:0002250,GO:0002548,GO:0002685,GO:0002685,GO:0005102,GO:0005509,GO:0005509,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005544,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005886,GO:0005912,GO:0005925,GO:0006909,GO:0006954,GO:0006954,GO:0007165,GO:0007166,GO:0007187,GO:0007187,GO:0008289,GO:0008360,GO:0008360,GO:0009986,GO:0010165,GO:0014839,GO:0016323,GO:0016324,GO:0016328,GO:0018149,GO:0019834,GO:0019834,GO:0030036,GO:0030036,GO:0030073,GO:0030216,GO:0030216,GO:0030850,GO:0031018,GO:0031340,GO:0031340,GO:0031394,GO:0031514,GO:0031901,GO:0031982,GO:0032355,GO:0032508,GO:0032652,GO:0032652,GO:0032717,GO:0032743,GO:0032743,GO:0033031,GO:0035924,GO:0035924,GO:0042063,GO:0042102,GO:0042102,GO:0042119,GO:0042383,GO:0043066,GO:0043434,GO:0045087,GO:0045627,GO:0045627,GO:0045629,GO:0045629,GO:0045920,GO:0045920,GO:0046632,GO:0046632,GO:0046883,GO:0046883,GO:0048306,GO:0050482,GO:0050727,GO:0050727,GO:0051179,GO:0062023,GO:0070062,GO:0070062,GO:0070301,GO:0070365,GO:0070459,GO:0070555,GO:0071385,GO:0071385,GO:0071621,GO:0071621,GO:0090050,GO:0090050,GO:0090303,GO:0090303,GO:0097350,GO:0097350,GO:0098609,GO:0098641,GO:1900087,GO:1900138

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ANXA1 PLA2G4A 17873281 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK1 ANXA1 21383699 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELA ANXA1 21383699 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG ANXA1 21383699 23180781 physical association anti tag coimmunoprecipitation InnateDB
ANXA1 MEIS2 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ANXA1 SRC 20005715 interaction type N/A PSP
ANXA1 FPR1 20005715 interaction type N/A PSP
ANXA1 TGM2 20005715 interaction type N/A PSP
ANXA1 PRKCI 20005715 interaction type N/A PSP
ANXA1 SRC 20005715 N/A N/A SignaLink
ANXA1 PRKCI 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ANXA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ANXA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ANXA1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ANXA1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ANXA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ANXA1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 ANXA1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 ANXA1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000170CF4 ANXA1 23630541 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA ANXA1 22135298 phosphorylation N/A PhosphoSite
SRC ANXA1 22135298 phosphorylation N/A PhosphoSite
ABL1 ANXA1 22135298 phosphorylation N/A PhosphoSite
TRPM7 ANXA1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCA ANXA1 22135298 phosphorylation N/A PhosphoSite
PRKCB ANXA1 22135298 phosphorylation N/A PhosphoSite
EGFR ANXA1 22135298 phosphorylation N/A PhosphoSite
ANXA1 S100A11 25361965 interaction type N/A PTMCode2
S100A11 ANXA1 25361965 interaction type N/A PTMCode2
ANXA1 KRT8 25361965 interaction type N/A PTMCode2
KRT8 ANXA1 25361965 interaction type N/A PTMCode2
ANXA1 PRKCI 25361965 interaction type N/A PTMCode2
PRKCI ANXA1 25361965 interaction type N/A PTMCode2
ANXA1 FPR1 25361965 interaction type N/A PTMCode2
FPR1 ANXA1 25361965 interaction type N/A PTMCode2
ANXA1 TRPM7 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I ANXA1 25348397 N/A physical interaction ComPPI
CDC73 ANXA1 25348397 N/A physical interaction ComPPI
CUL5 ANXA1 25348397 N/A physical interaction ComPPI
MEIS2 ANXA1 25348397 N/A two hybrid,physical interaction ComPPI
DHX15 ANXA1 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BAG3 ANXA1 25348397 N/A physical interaction ComPPI
ANXA1 PPM1B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 DLG3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 S100A11 12645011 14525934 25348397 27898060 8557678 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ANXA1 KRT8 14525934 25348397 27898060 9459484 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ANXA1 USP25 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 USPL1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 SLX1A 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 ATG4B 25348397 N/A physical interaction ComPPI
ANXA1 MGMT 25348397 N/A physical interaction ComPPI
ANXA1 UCHL5 25348397 N/A physical interaction ComPPI
ANXA1 UBE3A 25348397 N/A physical interaction ComPPI
ANXA1 CD4 25348397 N/A physical interaction ComPPI
ANXA1 GAPDH 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 KLHL23 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 APBB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 CSAD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 CZIB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 RPA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 UNC119 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 OTUB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 ERG28 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 XRCC6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 KMT2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 CCT7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 COPS6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 LRIF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 FAF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 ANXA5 25348397 N/A physical interaction ComPPI
ANXA1 SIRT7 25348397 N/A physical interaction ComPPI
ANXA1 CDK2 25348397 N/A physical interaction ComPPI
ANXA1 IKBKG 21383699 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,molecular sieving,physical interaction,confocal microscopy ComPPI,IntAct
ANXA1 RIPK1 21383699 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,molecular sieving,physical interaction,confocal microscopy ComPPI,IntAct
ANXA1 RELA 21383699 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 ANXA4 25348397 N/A physical interaction ComPPI
ANXA1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ANXA1 VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ANXA1 ITGA4 25348397 N/A physical interaction ComPPI
ANXA1 HMGA1 25348397 N/A filter binding,physical interaction ComPPI
ANXA1 ATP4A 25348397 N/A physical interaction ComPPI
ANXA1 YWHAQ 25348397 N/A physical interaction ComPPI
ANXA1 HECW2 25348397 N/A physical interaction ComPPI
ANXA1 WWOX 25348397 N/A physical interaction ComPPI
ANXA1 ZBTB1 25348397 N/A physical interaction ComPPI
ANXA1 ENO1 25348397 N/A physical interaction ComPPI
ANXA1 MOV10 25348397 N/A physical interaction ComPPI
ANXA1 NXF1 25348397 N/A physical interaction ComPPI
ANXA1 CUL7 25348397 N/A physical interaction ComPPI
ANXA1 OBSL1 25348397 N/A physical interaction ComPPI
ANXA1 SUMO2 25348397 N/A physical interaction ComPPI
ANXA1 NSL1 25348397 N/A physical interaction ComPPI
ANXA1 UCP2 25348397 N/A physical interaction ComPPI
ANXA1 SOX2 25348397 N/A physical interaction ComPPI
ANXA1 KIR2DL3 25348397 N/A physical interaction ComPPI
ANXA1 KIR2DS2 25348397 N/A physical interaction ComPPI
ANXA1 UGT1A10 25348397 N/A physical interaction ComPPI
ANXA1 ZSCAN20 25348397 N/A physical interaction ComPPI
ANXA1 TP53BP2 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 MAP1S 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 STK4 23386615 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
ANXA1 RASSF10 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 HNRNPA1 25348397 N/A physical interaction ComPPI
ANXA1 HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
ANXA1 CEP152 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ANXA1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ANXA1 CEP89 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ANXA1 DCTN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ANXA1 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 PPIA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 TFG 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 CCDC88A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA1 USP7 25348397 N/A physical interaction ComPPI
ANXA1 MCM2 25348397 N/A physical interaction ComPPI
ANXA1 EGFR 14525934 15581623 20029029 24189400 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,experimental interaction detection,ubiquitin reconstruction,physical interaction,imaging technique,tandem affinity purification ComPPI,HPRD,IntAct
ANXA1 U2AF2 25348397 N/A physical interaction ComPPI
ANXA1 ACTA1 25348397 N/A physical interaction ComPPI
ANXA1 PLA2G4A 17873281 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ANXA1 CDH1 25348397 N/A physical interaction ComPPI
ANXA1 GNB2 25348397 N/A physical interaction ComPPI
ANXA1 FRMD1 25348397 N/A physical interaction ComPPI
ANXA1 RPUSD3 25348397 N/A physical interaction ComPPI
ANXA1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ANXA1 TRIM25 25348397 N/A physical interaction ComPPI
ANXA1 G3BP1 25348397 N/A physical interaction ComPPI
ANXA1 BRCA1 25348397 N/A physical interaction ComPPI
ANXA1 CFTR 25348397 N/A physical interaction ComPPI
ANXA1 KEAP1 25348397 N/A physical interaction ComPPI
ANXA1 NFKBIA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ANXA1 ACTB 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
ANXA1 YWHAZ 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
ANXA1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ANXA1 SQSTM1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ANXA1 PTPN11 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 PTPN6 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 CCAR2 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 HSPA1A 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 HSPA1B 25348397 N/A anti bait coimmunoprecipitation ComPPI
ANXA1 DLAT 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 PKLR 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 COL1A1 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 RBM14 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 CYLD 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 ACTG1 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 WDCP 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 DAB2 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 FLOT2 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 DDX17 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 RBMX 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 RPLP0 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 DDX41 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 RPS14 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 PABPN1 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 TLE3 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ANXA1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
ANXA1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
UBE2D1 ANXA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DDX19B ANXA1 25348397 N/A physical interaction ComPPI
ATF2 ANXA1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCI ANXA1 14525934 2457390 N/A experimental interaction detection HPRD
ANXA1 FPR1 10882119 14525934 N/A experimental interaction detection HPRD
SRC ANXA1 14525934 2457390 N/A experimental interaction detection HPRD
TGM2 ANXA1 14525934 1670773 27898060 N/A experimental interaction detection HPRD,OmniPath
DYSF ANXA1 14506282 14525934 N/A experimental interaction detection HPRD
TRPM7 ANXA1 14525934 15485879 N/A experimental interaction detection HPRD
METTL3 ANXA1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
WTAP ANXA1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
SRC ANXA1 15485879 1956339 24103589 2457390 27898060 stimulant N/A OmniPath
PRKACA ANXA1 2457390 27898060 N/A N/A OmniPath
PRKCA ANXA1 11482905 1956339 19625660 24103589 2457390 27898060 stimulant N/A OmniPath
PRKCB ANXA1 19428336 24103589 27898060 stimulant N/A OmniPath
TRPM7 ANXA1 15485879 20068231 21280599 24103589 24939696 27898060 stimulant N/A OmniPath
EGFR ANXA1 15581623 16052208 17081983 20029029 24103589 2457390 24782913 27898060 stimulant N/A OmniPath
ANXA1 IKBKG 21383699 27898060 N/A N/A OmniPath
IKBKG ANXA1 21383699 27898060 N/A N/A OmniPath
PRKCG ANXA1 24103589 27898060 stimulant N/A OmniPath
ABL1 ANXA1 2457390 27898060 N/A N/A OmniPath
ANXA1 RELA 21383699 27898060 N/A N/A OmniPath
ANXA1 RIPK1 21383699 27898060 N/A N/A OmniPath
RIPK1 ANXA1 21383699 27898060 N/A N/A OmniPath
ANXA1 FPR3 15187149 27898060 N/A N/A OmniPath
ANXA1 FPR2 12368905 22610094 27898060 N/A N/A OmniPath
PRKCH ANXA1 24103589 27898060 stimulant N/A OmniPath
ANXA1 FPR1 10882119 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BF5A5 ANXA1 27087310 direct interaction,inhibition N/A NPInter

Visualization










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