GENE：ARSB
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ARSB |
| FullNmae | arylsulfatase B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:714 |
| EnsembleID | ENSG00000113273 |
| Uniprot | P15848 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ARSB | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| ARSB | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| ARSB | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ARSB | GO:0003943,GO:0004065,GO:0005576,GO:0005764,GO:0005788,GO:0006914,GO:0007040,GO:0007041,GO:0007584,GO:0009268,GO:0009986,GO:0010632,GO:0010976,GO:0035578,GO:0043202,GO:0043627,GO:0046872,GO:0051597,GO:0061580,GO:0070062,GO:1904813 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ARSB | hsa:411 | path:hsa00531 | Glycosaminoglycan degradation - Homo sapiens (human) |
| ARSB | hsa:411 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ARSB | hsa:411 | path:hsa04142 | Lysosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ARSB | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ARSB | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | ARSB | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ARSB | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ARSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | ARSB | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | ARSB | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000184017 | ARSB | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000017EA6A | ARSB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | ARSB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B6B84 | ARSB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E008F | ARSB | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000078918 | ARSB | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | ARSB | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | ARSB | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000013DD8 | ARSB | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AVP | ARSB | 25348397 | N/A | physical interaction | ComPPI |
| PLAUR | ARSB | 25348397 | N/A | physical interaction | ComPPI |
| MYC | ARSB | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| ELAVL1 | ARSB | 25348397 | N/A | physical interaction | ComPPI |
| ESR1 | ARSB | 21182205 24234451 25348397 | association | affinity chromatography technology,physical interaction | ComPPI,IntAct |
| DEFA1 | ARSB | 25348397 | N/A | physical interaction | ComPPI |
| ERP29 | ARSB | 25348397 | N/A | physical interaction | ComPPI |
| PTPRK | ARSB | 25348397 | N/A | physical interaction | ComPPI |