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GENE：BCR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCR
FullNmae BCR activator of RhoGEF and GTPase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1014
EnsembleID ENSG00000186716
Uniprot P11274

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BCR GO:0002692,GO:0003014,GO:0004674,GO:0004713,GO:0005085,GO:0005085,GO:0005085,GO:0005096,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0006468,GO:0006909,GO:0007165,GO:0007264,GO:0007420,GO:0014069,GO:0016020,GO:0016020,GO:0030036,GO:0030216,GO:0030424,GO:0032991,GO:0035023,GO:0042472,GO:0043114,GO:0043197,GO:0043312,GO:0043314,GO:0048041,GO:0048872,GO:0050728,GO:0050766,GO:0050804,GO:0050885,GO:0051056,GO:0051171,GO:0051726,GO:0060216,GO:0060268,GO:0060313,GO:0065002,GO:0070062,GO:0071222,GO:0090630,GO:0090630,GO:0098685,GO:0098978,GO:0106310,GO:1905517,GO:1905522,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCR hsa:613 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BCR hsa:613 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCR ERBIN 15123239 23180781 physical association anti tag coimmunoprecipitation,gst pull down,peptide array InnateDB
BCR CSF2RB 23180781 8758906 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
BCR ABL1 12543778 1712671 23331499 8112292 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CRK BCR 20005715 interaction type N/A PSP
GIPC1 BCR 20005715 interaction type N/A PSP,SignaLink
GRB10 BCR 20005715 interaction type N/A PSP
GRB2 BCR 10887132 15143164 20005715 21071413 7529874 9178913 9747873 interaction type N/A PSP,SignaLink
IRS1 BCR 20005715 interaction type N/A PSP
AFDN BCR 20005715 interaction type N/A PSP
PXN BCR 20005715 21071413 8641358 interaction type N/A PSP,SignaLink
SHC1 BCR 20005715 interaction type N/A PSP
YWHAB BCR 20005715 interaction type N/A PSP
YWHAE BCR 20005715 interaction type N/A PSP
YWHAG BCR 20005715 interaction type N/A PSP
YWHAH BCR 20005715 interaction type N/A PSP
YWHAQ BCR 20005715 interaction type N/A PSP
YWHAZ BCR 20005715 interaction type N/A PSP
CRK BCR 18988627 20005715 20005715 8978305 N/A N/A SignaLink
GRB10 BCR 18988627 20005715 20005715 21071413 9747873 9747873 9747873 9747873 N/A N/A SignaLink
AFDN BCR 12808105 20005715 20005715 21071413 N/A N/A SignaLink
YWHAB BCR 20005715 20005715 N/A N/A SignaLink
YWHAQ BCR 20005715 20005715 N/A N/A SignaLink
YWHAZ BCR 16045749 18988627 20005715 20005715 7939633 N/A N/A SignaLink
IRS1 BCR 12560071 18988627 20005715 20005715 N/A N/A SignaLink
SHC1 BCR 18988627 20005715 20005715 9209414 N/A N/A SignaLink
YWHAE BCR 20005715 20005715 N/A N/A SignaLink
YWHAG BCR 20005715 20005715 N/A N/A SignaLink
YWHAH BCR 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR BCR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BCR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 BCR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 BCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE BCR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 BCR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 BCR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075E538 BCR 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F72ED BCR 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BCR YWHAQ 22135298 phosphorylation N/A PhosphoSite
BCR YWHAZ 22135298 phosphorylation N/A PhosphoSite
BCR AFDN 22135298 phosphorylation N/A PhosphoSite
ABL1 BCR 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
FES BCR 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HCK BCR 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
FYN BCR 22135298 phosphorylation N/A PhosphoSite
LYN BCR 22135298 phosphorylation N/A PhosphoSite
CBL BCR 25361965 interaction type N/A PTMCode2
BCR CBL 25361965 interaction type N/A PTMCode2
KIT BCR 25361965 interaction type N/A PTMCode2
BCR KIT 25361965 interaction type N/A PTMCode2
CRK BCR 25361965 interaction type N/A PTMCode2
BCR CRK 25361965 interaction type N/A PTMCode2
GRAP BCR 25361965 interaction type N/A PTMCode2
BCR GRAP 25361965 interaction type N/A PTMCode2
PIK3R1 BCR 25361965 interaction type N/A PTMCode2
BCR PIK3R1 25361965 interaction type N/A PTMCode2
BLK BCR 25361965 interaction type N/A PTMCode2
BCR BLK 25361965 interaction type N/A PTMCode2
GAB2 BCR 25361965 interaction type N/A PTMCode2
BCR GAB2 25361965 interaction type N/A PTMCode2
HNF1A BCR 25361965 interaction type N/A PTMCode2
BCR HNF1A 25361965 interaction type N/A PTMCode2
BCR IRS1 25361965 interaction type N/A PTMCode2
IRS1 BCR 25361965 interaction type N/A PTMCode2
BCR WDR48 25361965 interaction type N/A PTMCode2
WDR48 BCR 25361965 interaction type N/A PTMCode2
BCR CDC42 25361965 interaction type N/A PTMCode2
CDC42 BCR 25361965 interaction type N/A PTMCode2
BCR FES 25361965 interaction type N/A PTMCode2
BCR GRB2 25361965 interaction type N/A PTMCode2
GRB2 BCR 25361965 interaction type N/A PTMCode2
BCR CRKL 25361965 interaction type N/A PTMCode2
CRKL BCR 25361965 interaction type N/A PTMCode2
BCR RAC1 25361965 interaction type N/A PTMCode2
RAC1 BCR 25361965 interaction type N/A PTMCode2
BCR SRC 25361965 interaction type N/A PTMCode2
SRC BCR 25361965 interaction type N/A PTMCode2
BCR PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG BCR 25361965 interaction type N/A PTMCode2
BCR PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 BCR 25361965 interaction type N/A PTMCode2
BCR ABL1 25361965 interaction type N/A PTMCode2
BCR HCK 25361965 interaction type N/A PTMCode2
BCR MYC 25361965 interaction type N/A PTMCode2
MYC BCR 25361965 interaction type N/A PTMCode2
BCR JAK2 25361965 interaction type N/A PTMCode2
JAK2 BCR 25361965 interaction type N/A PTMCode2
BCR LRRK1 25361965 interaction type N/A PTMCode2
LRRK1 BCR 25361965 interaction type N/A PTMCode2
BCR GRB10 25361965 interaction type N/A PTMCode2
GRB10 BCR 25361965 interaction type N/A PTMCode2
BCR SOS1 25361965 interaction type N/A PTMCode2
SOS1 BCR 25361965 interaction type N/A PTMCode2
BCR PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 BCR 25361965 interaction type N/A PTMCode2
BCR SHC1 25361965 interaction type N/A PTMCode2
SHC1 BCR 25361965 interaction type N/A PTMCode2
BCR MAP4K5 25361965 interaction type N/A PTMCode2
MAP4K5 BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 BCR 25348397 N/A physical interaction ComPPI
HSPA8 BCR 25348397 N/A physical interaction ComPPI
CDC42 BCR 25348397 N/A physical interaction ComPPI
UBASH3B BCR 25348397 N/A physical interaction ComPPI
GRAP BCR 24234451 25348397 8995379 association pull down ComPPI,IntAct
YWHAG BCR 14525934 16045749 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ERCC3 BCR 14525934 25348397 9874796 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN6 BCR 14525934 25348397 9211920 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MCM6 BCR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MCM2 BCR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAC1 BCR 25348397 N/A physical interaction ComPPI
CRK BCR 14525934 25348397 8978305 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ERBIN BCR 25348397 N/A physical interaction ComPPI
CBL BCR 25348397 N/A physical interaction ComPPI
VAV1 BCR 11790798 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
KIT BCR 24234451 25241761 25348397 27898060 8757502 physical association physical interaction,proximity ligation assay ComPPI,IntAct,OmniPath
PIK3R1 BCR 25348397 N/A physical interaction ComPPI
PTPN11 BCR 12115002 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SRC BCR 1383690 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRB10 BCR 14525934 25348397 9747873 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CRKL BCR 14525934 25348397 8978305 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
DOK1 BCR 25348397 N/A physical interaction ComPPI
INPP5D BCR 25348397 N/A physical interaction ComPPI
SHC1 BCR 14525934 25348397 9209414 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SOS1 BCR 25348397 N/A physical interaction ComPPI
PIK3CG BCR 24234451 25241761 25348397 27898060 7606002 physical association physical interaction,proximity ligation assay ComPPI,IntAct,OmniPath
UNC119 BCR 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GAB2 BCR 25348397 N/A physical interaction ComPPI
GRB2 BCR 10887132 11726515 14525934 21706016 24234451 25348397 8112292 8955135 8995379 9174058 9178913 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RB1 BCR 25348397 N/A physical interaction ComPPI
HIF1A BCR 25348397 N/A physical interaction ComPPI
BLK BCR 14525934 25348397 8756631 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA BCR 25348397 N/A physical interaction ComPPI
YWHAB BCR 14525934 16045749 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
YWHAZ BCR 14525934 16045749 25348397 7939633 N/A experimental interaction detection,in vitro ComPPI,HPRD
FES BCR 14525934 25348397 7529874 8955135 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBC BCR 25348397 N/A physical interaction ComPPI
HSP90AA1 BCR 25348397 N/A physical interaction ComPPI
NTRK1 BCR 25348397 N/A physical interaction ComPPI
PTPN1 BCR 14525934 25348397 9566916 N/A experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD
COPB1 BCR 15494376 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PTGES3 BCR 25348397 N/A physical interaction ComPPI
MYC BCR 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PXN BCR 25348397 N/A physical interaction ComPPI
NAGK BCR 25348397 N/A physical interaction ComPPI
HNRNPL BCR 25348397 N/A physical interaction ComPPI
GABRR1 BCR 25348397 N/A physical interaction ComPPI
CFTR BCR 15494376 17110338 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
GIPC1 BCR 15494376 24234451 25348397 physical association filter binding ComPPI,IntAct
RAD51 BCR 25348397 N/A physical interaction ComPPI
GRK5 BCR 25348397 N/A physical interaction ComPPI
XPO1 BCR 25348397 N/A physical interaction ComPPI
YWHAQ BCR 14525934 16045749 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CLTC BCR 15494376 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
CCDC183 BCR 25348397 N/A physical interaction ComPPI
DLG1 BCR 14525934 16825666 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CSNK2A2 BCR 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PDZK1 BCR 15494376 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
RASA1 BCR 1383690 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCR YWHAH 14525934 16045749 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCR SFN 14525934 16045749 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCR YWHAE 14525934 16045749 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCR ABL2 1383690 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCR APBA3 14525934 15494376 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,filter binding,pull down,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
BCR IRS1 12560071 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCR IGSF21 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
BCR HNF1A 14525934 16442529 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCR HCK 12522270 14525934 25348397 8955135 9178913 9407116 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCR JAK2 12023981 12370803 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BCR MAP4K5 14525934 25348397 9949177 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCR AFDN 17491594 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
BCR ABL1 11780146 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCR TP53 14525934 16169070 24234451 25241761 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
BCR IL3 25348397 N/A physical interaction ComPPI
BCR WDR48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCR TSG101 16778200 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BCR VPS28 25348397 N/A physical interaction ComPPI
BCR HSP90AA2P 25348397 N/A physical interaction ComPPI
BCR LNX1 25348397 N/A physical interaction ComPPI
BCR LRRK1 20697350 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BCR AP2M1 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BCR HSPA4 25348397 N/A physical interaction ComPPI
BCR HSPD1 25348397 N/A physical interaction ComPPI
BCR STUB1 25348397 N/A physical interaction ComPPI
BCR RSPH9 25348397 N/A physical interaction ComPPI
BCR SEC13 25348397 N/A physical interaction ComPPI
BCR CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
BCR NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
BCR PDZK1P1 25348397 N/A physical interaction ComPPI
BCR COMMD1 25348397 N/A physical interaction ComPPI
BCR TULP3 25348397 N/A physical interaction ComPPI
BCR JPH4 25348397 N/A physical interaction ComPPI
BCR USP15 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BCR SPAG9 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BCR MCM4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BCR WEE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BCR CSNK1A1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BCR TRIM25 25348397 N/A physical interaction ComPPI
BCR TJP2 15494376 24234451 25348397 physical association filter binding ComPPI,IntAct
BCR RGS12 15494376 24234451 25348397 physical association filter binding ComPPI,IntAct
BCR ATP2B1 15494376 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
BCR TCF7 16442529 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BCR TNKS2 22153077 24234451 25348397 association,physical association anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,pull down ComPPI,IntAct
BCR EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB BCR 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
BCR PLCG1 1383690 14525934 N/A experimental interaction detection HPRD
BCR BCR 11780146 14525934 N/A experimental interaction detection HPRD
STK38L BCR 24234451 30108113 association proximity-dependent biotin identification IntAct
PTPN1 BCR 27898060 9566916 inhibition N/A OmniPath
HCK BCR 10849448 12522270 12592324 16497976 16912036 18083107 19690332 27898060 8955135 9178913 9407116 stimulant N/A OmniPath
ABL1 BCR 11780146 12124177 12543778 16912036 1712671 20841568 27898060 8112292 8622703 9178913 9407116 9467953 inhibition,stimulant N/A OmniPath
BCR ABL1 11780146 12543778 1712671 27898060 8112292 stimulant N/A OmniPath
CSNK2A1 BCR 11084041 27898060 9467953 N/A N/A OmniPath
BCR YWHAQ 16045749 18669648 18691976 19415658 19664995 20068231 27898060 9360956 stimulant N/A OmniPath
BCR CSF2RB 27898060 8758906 N/A N/A OmniPath
CSF2RB BCR 27898060 8758906 N/A N/A OmniPath
BCR ERBIN 15123239 27898060 N/A N/A OmniPath
ERBIN BCR 15123239 27898060 N/A N/A OmniPath
FES BCR 10405761 10706130 12522270 15302586 16497976 27898060 7529874 8955135 9178913 9407116 inhibition,stimulant N/A OmniPath

Visualization










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