Gene Information gene info

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GENE：BLNK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BLNK
FullNmae B cell linker
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14211
EnsembleID ENSG00000095585
Uniprot Q8WV28

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BLNK immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BLNK GO:0005068,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006954,GO:0006959,GO:0007169,GO:0008289,GO:0010628,GO:0016020,GO:0019899,GO:0019901,GO:0030183,GO:0035556,GO:0035556,GO:0035591,GO:0042169,GO:0043231,GO:0043274,GO:0050853,GO:0050853,GO:1990782

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BLNK hsa:29760 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
BLNK hsa:29760 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
BLNK hsa:29760 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
BLNK hsa:29760 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
BLNK hsa:29760 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
REL BLNK 18245482 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IGHD BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
IGKC BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
CD79A BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
CD79B BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
IGHM BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
SYK BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
BLNK SH3KBP1 11071869 12456653 21822214 22262777 29145629 9697839 physical association inferred by curator Reactome
SOS1 BLNK 11071869 12456653 21822214 22262777 29145629 9697839 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
BLNK ERBB2 20005715 interaction type N/A PSP,SignaLink
BLNK CD79A 20005715 interaction type N/A PSP
BLNK PLCG2 20005715 interaction type N/A PSP
BLNK PLCG1 20005715 interaction type N/A PSP
BLNK PTPN6 20005715 interaction type N/A PSP
BLNK SYK 10981967 18988627 20005715 interaction type N/A PSP,SignaLink
BLNK CRKL 20005715 interaction type N/A PSP
BLNK BTK 20005715 interaction type N/A PSP
BLNK ITK 20005715 interaction type N/A PSP
BLNK CBLB 20005715 interaction type N/A PSP
BLNK MAP4K1 20005715 interaction type N/A PSP
BLNK CRKL 11489945 18988627 20005715 21071413 N/A N/A SignaLink
BLNK ITK 10556826 18988627 20005715 20005715 N/A N/A SignaLink
BLNK MAP4K1 11514608 18988627 20005715 20005715 N/A N/A SignaLink
BLNK PLCG1 20005715 20005715 N/A N/A SignaLink
BLNK PTPN6 10903736 11356834 11356834 15588985 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA3 BLNK 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 BLNK 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BLNK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 BLNK 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
SYK BLNK 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NCK2 BLNK 25348397 N/A physical interaction ComPPI
LCP2 BLNK 14525934 25348397 9697839 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SH3KBP1 BLNK 11071869 14525934 21822214 24234451 25348397 N/A two hybrid,experimental interaction detection,pull down,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
PTPN6 BLNK 10903736 11356834 14525934 15588985 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ERBB2 BLNK 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
CBL BLNK 10684856 25348397 27898060 N/A physical interaction ComPPI,OmniPath
VAV1 BLNK 14525934 25348397 9697839 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK BLNK 10498607 10556826 14525934 16969585 24234451 25348397 physical association experimental interaction detection,far western blotting,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SYK BLNK 10981967 14525934 18369315 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
CBLB BLNK 12093870 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BLNK CD72 10820378 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BLNK ITK 10556826 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BLNK GRB2 10556826 14525934 16912232 21822214 24234451 25348397 9697839 9705962 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BLNK PLCG2 21822214 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
BLNK NCK1 11487585 14525934 24234451 25241761 25348397 9697839 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
BLNK CD79A 11449366 11909947 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BLNK MAP4K1 11514608 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BLNK CRKL 11489945 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
BLNK CMTM3 14525934 15087455 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
BLNK GRAP2 12176364 12773374 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BLNK CD2AP 21822214 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
BLNK CAPZA1 25348397 N/A physical interaction ComPPI
BLNK CAPZA2 25348397 N/A physical interaction ComPPI
BLNK CAPZB 25348397 N/A physical interaction ComPPI
BLNK HSPA4 25348397 N/A physical interaction ComPPI
BLNK HSPH1 25348397 N/A physical interaction ComPPI
BLNK MYBPC3 25348397 N/A physical interaction ComPPI
BLNK CLEC17A 25348397 N/A physical interaction ComPPI
BLNK DOK3 21822214 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BLNK TLN1 25348397 N/A physical interaction ComPPI
BLNK LYN 25348397 N/A physical interaction ComPPI
BLNK VAV3 25348397 N/A physical interaction ComPPI
BLNK MAP2K4 21822214 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BLNK PPP2R2C 25348397 N/A physical interaction ComPPI
BLNK AIFM1 25348397 N/A physical interaction ComPPI
BLNK WDR81 25348397 N/A physical interaction ComPPI
BLNK PLCG1 14525934 25348397 9697839 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BLNK HNRNPL 25348397 N/A physical interaction ComPPI
BLNK AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BLNK KIT 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GAB1 BLNK 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SYK BLNK 10981967 12456653 18369315 21394647 21482705 21822214 27898060 9697839 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BC055 BLNK 27087310 direct interaction,inhibition N/A NPInter

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