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GENE：BTK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BTK
FullNmae Bruton tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1133
EnsembleID ENSG00000010671
Uniprot Q06187

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BTK necroptosis 39885663 In a TNF-α-induced lung epithelial cell injury model, luteolin reduced the increased expression of IL1B, IL6, and CXCL8 mRNAs by blocking the necroptosis signal TNF-α/BTK/MLKL. retulator signature
BTK lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
BTK lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BTK immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BTK apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BTK apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BTK GO:0001780,GO:0001805,GO:0001812,GO:0002250,GO:0002250,GO:0002344,GO:0002553,GO:0002639,GO:0002721,GO:0002755,GO:0002902,GO:0004713,GO:0004713,GO:0004713,GO:0004715,GO:0004715,GO:0004715,GO:0004715,GO:0005515,GO:0005524,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006468,GO:0006468,GO:0007249,GO:0007498,GO:0016004,GO:0018108,GO:0018108,GO:0019722,GO:0030167,GO:0030889,GO:0030890,GO:0031410,GO:0032496,GO:0032693,GO:0032755,GO:0032760,GO:0034614,GO:0035556,GO:0035556,GO:0035556,GO:0038095,GO:0042113,GO:0042802,GO:0043274,GO:0045087,GO:0045121,GO:0045579,GO:0046872,GO:0048469,GO:0048471,GO:0050766,GO:0050852,GO:0050853,GO:0050853,GO:0050853,GO:0051092,GO:0061516,GO:0071226,GO:0097190,GO:0098761,GO:0150153,GO:1900227,GO:1901647,GO:1990959

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BTK hsa:695 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
BTK hsa:695 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
BTK hsa:695 path:hsa04611 Platelet activation - Homo sapiens (human)
BTK hsa:695 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
BTK hsa:695 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
BTK hsa:695 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
BTK hsa:695 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TIRAP BTK 16439361 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
BTK TLR4 12724322 23180781 physical association two hybrid InnateDB
MYD88 BTK 12724322 23180781 physical association anti tag coimmunoprecipitation InnateDB
BTK IRAK1 12724322 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR8 BTK 12724322 17932028 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TLR6 BTK 12724322 23180781 physical association two hybrid InnateDB
BTK TLR9 12724322 17932028 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
BTK ABL1 12445832 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
BTK FAS 23180781 9880544 physical association anti tag coimmunoprecipitation InnateDB
STAT3 BTK 17367410 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT5A BTK 11413148 23180781 physical association anti tag coimmunoprecipitation InnateDB
WAS BTK 10068673 10590061 23180781 9742969 physical association anti tag coimmunoprecipitation,gst pull down,protein kinase assay InnateDB
PRKCB BTK 12679936 23180781 physical association gst pull down InnateDB
BTK BTK 11544529 12724322 15184383 15944945 16439361 17726518 17932028 18070880 21659545 21873236 22454496 23180781 24243840 29145629 phosphorylation reaction,enzymatic reaction,physical association inferred by curator,protein kinase assay InnateDB,Reactome
BCL6 BTK 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
BTK IKZF1 23180781 23977012 physical association anti tag coimmunoprecipitation InnateDB
BTK TIRAP 23180781 24840642 physical association docking InnateDB
BTK SOS1 12573241 15184383 15365099 21659545 24243840 29145629 7518558 8629002 8630736 8986718 enzymatic reaction,physical association inferred by curator Reactome
PLCG1 BTK 12573241 15184383 15365099 21659545 24243840 29145629 7518558 8629002 8630736 8986718 enzymatic reaction,physical association inferred by curator Reactome
PLCG2 BTK 12573241 15184383 15365099 21659545 24243840 29145629 7518558 8629002 8630736 8986718 enzymatic reaction,physical association inferred by curator Reactome
VAV1 BTK 12573241 24243840 29145629 7518558 8629002 8630736 enzymatic reaction,physical association inferred by curator Reactome
SYK BTK 12573241 15184383 21659545 24243840 29145629 7518558 8629002 8630736 8986718 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
BLNK BTK 20005715 interaction type N/A PSP
CAV1 BTK 11751885 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
CD19 BTK 20005715 interaction type N/A PSP
GNG2 BTK 20005715 interaction type N/A PSP
SH2B2 BTK 20005715 interaction type N/A PSP
SH3BP5 BTK 20005715 interaction type N/A PSP
WASF2 BTK 20005715 interaction type N/A PSP
SH2B2 BTK 10872802 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA2 BTK 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 BTK 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BTK 10362515 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 BTK 10362515 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 BTK 10362515 trascriptional regulation,stimulation inferred by curator TFlink
SP3 BTK 10362515 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 BTK N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000134ADC BTK 19342689 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000134ADC BTK 19342689 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000055128B BTK 25416803 27756747 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,miRNA interference luciferase reporter assay TarBase
URS000048BA36 BTK 25416803 27756747 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,miRNA interference luciferase reporter assay TarBase
URS00001CE046 BTK 25416803 27756747 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SYK BTK 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
TEC BTK 22135298 phosphorylation N/A PhosphoSite
ABL1 BTK 22135298 phosphorylation N/A PhosphoSite
ITK BTK 22135298 phosphorylation N/A PhosphoSite
AKT1 BTK 22135298 phosphorylation N/A PhosphoSite
LYN BTK 22135298 phosphorylation N/A PhosphoSite
BTK PLCG2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
BTK TIRAP 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
BTK BTK 22135298 phosphorylation N/A PhosphoSite
BTK ITK 22135298 phosphorylation N/A PhosphoSite
BTK DDX41 22135298 phosphorylation N/A PhosphoSite
BTK BMX 22135298 phosphorylation N/A PhosphoSite
BTK IKZF1 22135298 phosphorylation N/A PhosphoSite
BTK TP53 22135298 phosphorylation N/A PhosphoSite
BTK TEC 22135298 phosphorylation N/A PhosphoSite
CBL BTK 25361965 interaction type N/A PTMCode2
BTK CBL 25361965 interaction type N/A PTMCode2
FCER1G BTK 25361965 interaction type N/A PTMCode2
BTK FCER1G 25361965 interaction type N/A PTMCode2
IBTK BTK 25361965 interaction type N/A PTMCode2
BTK IBTK 25361965 interaction type N/A PTMCode2
BTK KHDRBS1 25361965 interaction type N/A PTMCode2
KHDRBS1 BTK 25361965 interaction type N/A PTMCode2
BTK GTF2I 25361965 interaction type N/A PTMCode2
GTF2I BTK 25361965 interaction type N/A PTMCode2
BTK PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 BTK 25361965 interaction type N/A PTMCode2
BTK GRB2 25361965 interaction type N/A PTMCode2
GRB2 BTK 25361965 interaction type N/A PTMCode2
BTK CAV1 25361965 interaction type N/A PTMCode2
CAV1 BTK 25361965 interaction type N/A PTMCode2
BTK STAT5A 25361965 interaction type N/A PTMCode2
STAT5A BTK 25361965 interaction type N/A PTMCode2
PLCG2 BTK 25361965 interaction type N/A PTMCode2
BTK FASLG 25361965 interaction type N/A PTMCode2
FASLG BTK 25361965 interaction type N/A PTMCode2
BTK FYN 25361965 interaction type N/A PTMCode2
FYN BTK 25361965 interaction type N/A PTMCode2
BTK SYK 25361965 interaction type N/A PTMCode2
BTK HCK 25361965 interaction type N/A PTMCode2
HCK BTK 25361965 interaction type N/A PTMCode2
BTK WAS 25361965 interaction type N/A PTMCode2
WAS BTK 25361965 interaction type N/A PTMCode2
TIRAP BTK 25361965 interaction type N/A PTMCode2
BTK RELA 25361965 interaction type N/A PTMCode2
RELA BTK 25361965 interaction type N/A PTMCode2
ARID3A BTK 25361965 interaction type N/A PTMCode2
BTK ARID3A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BCL2L11 BTK 25348397 N/A physical interaction ComPPI
KRT5 BTK 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ATP5F1B BTK 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
WAS BTK 10068673 12235133 12769846 14525934 24234451 25348397 8892607 9742969 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MEOX2 BTK 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
HSP90AB1 BTK 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
ARID3A BTK 14525934 15203319 19214191 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CBL BTK 10427990 14525934 25348397 7629518 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VAV1 BTK 14525934 25348397 9201297 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK LYN 11226282 11598012 14525934 25348397 8058772 8629002 8630736 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK PRKCB 11598012 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK ITK 11598012 12445832 12573241 14525934 25348397 8629002 8630736 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK PRKCZ 11788586 14525934 25348397 7522330 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK PRKCQ 11788586 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
BTK PRKCE 11788586 14525934 25348397 7522330 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK PRKCA 11788586 14525934 25348397 7522330 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK SYK 11226282 11598012 14525934 25348397 8629002 8630736 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK PLCG2 25348397 N/A physical interaction,in vitro ComPPI
BTK TEC 11598012 12445832 12573241 14525934 25348397 8629002 8630736 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK GNAQ 14525934 25348397 9770463 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK CAV1 11751885 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BTK STAT5A 11413148 14525934 25348397 7925280 8617237 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK GTF2I 10373551 11313464 11373296 11934902 14525934 14623887 19214191 24234451 25348397 9012831 9837922 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
BTK KHDRBS1 14525934 25348397 9201297 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK BLNK 10498607 10556826 14525934 16969585 24234451 25348397 physical association experimental interaction detection,far western blotting,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BTK PRKD1 10561498 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK SH3BP5 10339589 14525934 24234451 25348397 9571151 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BTK IBTK 11577348 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
BTK SH2B2 10872802 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BTK GNG2 11698416 14525934 25348397 7972043 N/A experimental interaction detection,in vivo ComPPI,HPRD
BTK DAPP1 11524430 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BTK RELA 14525934 15849198 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BTK KIT 14525934 15007095 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BTK IRAK1 12724322 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK TLR8 12724322 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BTK MYD88 12724322 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK PIP5K1B 25348397 N/A in vitro,in vivo ComPPI
BTK TLR4 12724322 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BTK PIP4K2B 14525934 14614850 15046600 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK PIP5K1A 25348397 N/A in vitro,in vivo ComPPI
BTK TNFRSF10A 14525934 15007095 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BTK TLR6 12724322 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BTK TLR9 12724322 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BTK PIP5K1C 14525934 14614850 15046600 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK TIRAP 25348397 N/A physical interaction,in vitro,in vivo ComPPI
BTK PIK3AP1 11163197 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BTK PIP4K2A 14525934 14614850 15046600 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK PIP4K2C 14525934 14614850 15046600 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTK CMTM3 14525934 15087455 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BTK EWSR1 14525934 25348397 9201297 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK FAS 14525934 25348397 9751072 N/A experimental interaction detection,in vivo ComPPI,HPRD
BTK HCK 14525934 25348397 8058772 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BTK JAK1 14525934 25348397 9178903 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK CD19 10201980 14525934 19214191 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
BTK RPS6KB1 25348397 N/A physical interaction ComPPI
BTK RPS6KB2 25348397 N/A physical interaction ComPPI
BTK FYN 25348397 N/A physical interaction ComPPI
BTK CBLB 25348397 N/A physical interaction ComPPI
BTK GRB2 19380743 20936779 24234451 25348397 association,physical association physical interaction,two hybrid pooling approach,tandem affinity purification ComPPI,IntAct
BTK FASLG 19807924 24234451 25348397 N/A phage display,physical interaction ComPPI,IntAct
BTK GNB1 25348397 N/A physical interaction ComPPI
BTK APP 25348397 N/A physical interaction ComPPI
BTK RPS3 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK AFG3L2 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK ACTA1 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK ACTN1 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK ATP5F1A 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK CORO1C 25348397 N/A physical interaction ComPPI
BTK DDX3X 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK DBN1 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK FLNA 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK GAPDH 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK HRNR 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK MYLK2 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK NDUFS1 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK SFPQ 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK SPTA1 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK HADHA 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK TUBA4A 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK TUBB4B 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK TWF1 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTK HSP90AA1 25348397 N/A physical interaction ComPPI
BTK HSP90AA2P 25348397 N/A physical interaction ComPPI
BTK PLAU 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BTK ARRB1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BTK MPP7 25348397 N/A physical interaction ComPPI
BTK PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
BTK BECN1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BTK MRPS22 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BTK SMURF1 25348397 N/A physical interaction ComPPI
BTK AURKA 25348397 N/A physical interaction ComPPI
BTK ANKRD54 25348397 N/A physical interaction ComPPI
BTK TTC9C 25348397 N/A physical interaction ComPPI
BTK MAP3K4 25348397 N/A physical interaction ComPPI
BTK CDC37 25348397 N/A physical interaction ComPPI
BTK KATNB1 25348397 N/A physical interaction ComPPI
BTK GP6 25348397 N/A phage display,physical interaction ComPPI
BTK FCER1G 11788586 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BTK IGHM 19214191 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BTK RFTN1 19214191 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BTK POTEKP 21080425 24234451 25348397 association pull down ComPPI,IntAct
BTK MAL 22366891 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,pull down,confocal microscopy ComPPI,IntAct
BTK AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BTK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GAB1 BTK 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BMX BTK 12573241 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED28 BTK 16964398 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
ARHGAP17 BTK 11431473 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EEF1A2 BTK 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ABL1 BTK 11598012 12445832 12573241 14525934 8629002 8630736 N/A experimental interaction detection HPRD
BTK BTK 11231015 11527964 11577348 11598012 12445832 12573241 14525934 24234451 8629002 8630736 phosphorylation reaction experimental interaction detection,x-ray crystallography,protein kinase assay HPRD,IntAct
GNA12 BTK 14525934 9796816 N/A experimental interaction detection HPRD
WASF2 BTK 10427990 14525934 N/A experimental interaction detection HPRD
PLCG1 BTK 14525934 15184383 N/A experimental interaction detection HPRD
TP53 BTK 14525934 15355990 N/A experimental interaction detection HPRD
SRC BTK 27898060 8629002 stimulant N/A OmniPath
LYN BTK 10051622 11226282 11598012 12445832 12573241 14597636 14656219 17932028 18083107 19369195 21441935 25704810 27898060 8058772 8629002 8630736 9012831 9188445 9326643 stimulant N/A OmniPath
PRKCB BTK 11598012 12679936 27898060 inhibition,stimulant N/A OmniPath
BTK PRKCB 11598012 12679936 27898060 N/A N/A OmniPath
BTK PLCG2 10981967 11507089 11606584 11971963 12093870 12181444 12780340 14656219 15184383 16497976 17239630 17290227 19690332 19901323 27898060 7682059 stimulant N/A OmniPath
BTK TLR8 12724322 17932028 27898060 N/A N/A OmniPath
STAT5A BTK 11413148 27898060 7925280 8617237 N/A N/A OmniPath
BTK STAT5A 11413148 16497976 17016520 17389395 27898060 7925280 8617237 N/A N/A OmniPath
AKT1 BTK 23754751 27898060 N/A N/A OmniPath
TLR4 BTK 12724322 27898060 N/A N/A OmniPath
MYD88 BTK 12724322 27898060 N/A N/A OmniPath
BTK GTF2I 10373551 11313464 11373296 11934902 14623887 15096481 16738337 20068231 27898060 9012831 9837922 stimulant N/A OmniPath
BTK TLR9 12724322 17932028 27898060 N/A N/A OmniPath
ABL1 BTK 11598012 12445832 12573241 16497976 27898060 8629002 8630736 N/A N/A OmniPath
BTK CD19 10201980 10933394 16497976 27898060 N/A N/A OmniPath
BTK FAS 27898060 9751072 9880544 inhibition N/A OmniPath
BTK STAT3 17367410 27898060 N/A N/A OmniPath
TIRAP BTK 12724322 16415872 16439361 24840642 27898060 N/A N/A OmniPath
BTK TIRAP 12724322 16415872 16439361 18070880 19775907 24840642 27898060 inhibition N/A OmniPath
IRAK1 BTK 12724322 27898060 N/A N/A OmniPath
BTK IRAK1 12724322 27898060 N/A N/A OmniPath
TEC BTK 11598012 12445832 12573241 16497976 27898060 8629002 8630736 stimulant N/A OmniPath
BTK TEC 11598012 12445832 12573241 27898060 8629002 8630736 stimulant N/A OmniPath
BTK WAS 10068673 10427990 10590061 12235133 12769846 16497976 18088087 19901323 27898060 8892607 9742969 N/A N/A OmniPath
BTK TLR6 12724322 27898060 N/A N/A OmniPath
SYK BTK 11226282 11598012 18083107 19369195 27898060 8629002 8630736 9012831 stimulant N/A OmniPath
BTK BMX 11331870 12573241 27898060 stimulant N/A OmniPath
BTK ITK 11598012 12445832 12573241 27898060 8629002 8630736 stimulant N/A OmniPath
ITK BTK 11598012 12445832 12573241 16497976 27898060 8629002 8630736 N/A N/A OmniPath
BTK DAPP1 10880360 11524430 17389395 19901323 27898060 N/A N/A OmniPath

Visualization










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