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GENE：C1S

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol C1S
FullNmae complement C1s
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1247
EnsembleID ENSG00000182326
Uniprot P09871

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
C1S immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
C1S GO:0004252,GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006958,GO:0042802,GO:0045087,GO:0072562

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
C1S hsa:716 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
C1S hsa:716 path:hsa05133 Pertussis - Homo sapiens (human)
C1S hsa:716 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
C1S hsa:716 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
C1S hsa:716 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
C1S C2 11527969 2244876 23180781 cleavage reaction protease assay InnateDB
C1S SERPING1 17488724 23180781 physical association comigration in sds page InnateDB
C1S C4B 23180781 9422791 cleavage reaction protease assay InnateDB
PITX3 C1S 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB
C1S C4A 22949645 23180781 cleavage reaction,physical association surface plasmon resonance,cleavage assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR C1S 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 C1S 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 C1S 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 C1S N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 C1S N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 C1S 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000486E0B C1S 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000047A67D C1S 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003003B4 C1S 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SERPING1 C1S 25361965 interaction type N/A PTMCode2
C1S SERPING1 25361965 interaction type N/A PTMCode2
C1R C1S 25361965 interaction type N/A PTMCode2
C1S C1R 25361965 interaction type N/A PTMCode2
C1S C1QA 25361965 interaction type N/A PTMCode2
C1QA C1S 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SERPING1 C1S 14525934 17488724 25348397 27898060 3756141 6604523 9882449 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
C1QA C1S 10878362 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
C1R C1S 10092586 12788922 14525934 17996945 2372546 2387866 24234451 25348397 9477945 protein cleavage,physical association experimental interaction detection,molecular sieving,surface plasmon resonance,physical interaction,protease assay,in vitro,in vivo,equilibrium dialysis ComPPI,HPRD,IntAct
CREB3 C1S 25348397 N/A two hybrid bait and prey pooling approach ComPPI
PPP4R1 C1S 25348397 N/A physical interaction ComPPI
C1S VKORC1 25348397 N/A physical interaction ComPPI
C1S FN1 25348397 N/A physical interaction ComPPI
C1S CCDC6 25348397 N/A physical interaction ComPPI
C1S REEP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C1S C1S 12788922 14525934 2387866 24234451 N/A experimental interaction detection,molecular sieving,x-ray crystallography HPRD,IntAct
C2 C1S 11527969 2244876 27898060 N/A N/A OmniPath

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