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GENE：C3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol C3
FullNmae complement C3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1318
EnsembleID ENSG00000125730
Uniprot P01024

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
C3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
C3 GO:0001798,GO:0001934,GO:0001970,GO:0004866,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005788,GO:0005886,GO:0006631,GO:0006954,GO:0006955,GO:0006956,GO:0006956,GO:0006957,GO:0006958,GO:0007165,GO:0007186,GO:0009617,GO:0009986,GO:0010575,GO:0010828,GO:0010866,GO:0010884,GO:0016322,GO:0031715,GO:0032991,GO:0034774,GO:0035578,GO:0035846,GO:0045745,GO:0045766,GO:0048260,GO:0060100,GO:0070062,GO:0072562,GO:0097242,GO:0097278,GO:0150062,GO:0150064,GO:2000427

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
C3 hsa:718 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
C3 hsa:718 path:hsa04145 Phagosome - Homo sapiens (human)
C3 hsa:718 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
C3 hsa:718 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
C3 hsa:718 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
C3 hsa:718 path:hsa05131 Shigellosis - Homo sapiens (human)
C3 hsa:718 path:hsa05133 Pertussis - Homo sapiens (human)
C3 hsa:718 path:hsa05134 Legionellosis - Homo sapiens (human)
C3 hsa:718 path:hsa05140 Leishmaniasis - Homo sapiens (human)
C3 hsa:718 path:hsa05142 Chagas disease - Homo sapiens (human)
C3 hsa:718 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
C3 hsa:718 path:hsa05152 Tuberculosis - Homo sapiens (human)
C3 hsa:718 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
C3 hsa:718 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
C3 hsa:718 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
C3 hsa:718 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
C3 hsa:718 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
C3 MASP1 11527969 23180781 cleavage reaction protease assay InnateDB
C3 MASP2 11527969 23180781 cleavage reaction protease assay InnateDB
C3 CFH 16023208 19050261 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
C3 CFI 16023208 2141838 23180781 cleavage reaction,protein cleavage protease assay InnateDB
C3 CR2 19164292 23180781 physical association nuclear magnetic resonance,solid phase assay InnateDB
C3 CFB 17921140 23180781 cleavage reaction protease assay InnateDB
C3 CD46 10960475 11971006 2141838 23180781 8666815 protein cleavage,physical association pull down,protease assay,solid phase assay InnateDB
C3 CR1 2141838 23180781 protein cleavage,physical association pull down,protease assay InnateDB
ITGB2 C3 23180781 4062888 physical association pull down InnateDB
C3 ITGAX 12554829 23180781 physical association surface plasmon resonance InnateDB
C3 FH 21285368 23180781 physical association surface plasmon resonance,x-ray crystallography InnateDB
C3 C3 21285368 23180781 physical association x-ray crystallography InnateDB
PITX3 C3 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTSG C3 23180781 24315997 physical association protease assay InnateDB
CTSL C3 23180781 24315997 physical association protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 C3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPD C3 8385337 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 C3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ESR2 C3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 C3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 C3 19088304 25416803 27292025 mrna cleavage,inhibition array technology,clip TarBase
URS00000AD002 C3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B C3 23313552 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 C3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 C3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F C3 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E C3 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 C3 21572407 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 C3 21572407 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 C3 21572407 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC C3 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA C3 21572407 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004214BB C3 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005CE28 C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD C3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 C3 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 C3 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000137EDE C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 C3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000007340 C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004AF715 C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C85B2 C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003B6B84 C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000031B6ED C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003E2232 C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000057FDB8 C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001A4ABF C3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000002569A C3 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
C3 CFP 25361965 interaction type N/A PTMCode2
CFP C3 25361965 interaction type N/A PTMCode2
C3 CFHR5 25361965 interaction type N/A PTMCode2
CFHR5 C3 25361965 interaction type N/A PTMCode2
C3 C3AR1 25361965 interaction type N/A PTMCode2
C3AR1 C3 25361965 interaction type N/A PTMCode2
C3 CD46 25361965 interaction type N/A PTMCode2
CD46 C3 25361965 interaction type N/A PTMCode2
C3 CFHR3 25361965 interaction type N/A PTMCode2
CFHR3 C3 25361965 interaction type N/A PTMCode2
C3 CFH 25361965 interaction type N/A PTMCode2
CFH C3 25361965 interaction type N/A PTMCode2
C3 VSIG4 25361965 interaction type N/A PTMCode2
VSIG4 C3 25361965 interaction type N/A PTMCode2
C3 CFI 25361965 interaction type N/A PTMCode2
CFI C3 25361965 interaction type N/A PTMCode2
C3 CFB 25361965 interaction type N/A PTMCode2
CFB C3 25361965 interaction type N/A PTMCode2
OLFM4 C3 25361965 interaction type N/A PTMCode2
C3 OLFM4 25361965 interaction type N/A PTMCode2
C5 C3 25361965 interaction type N/A PTMCode2
C3 C5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PDE4DIP C3 25348397 N/A physical interaction ComPPI
PLEKHF2 C3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CA8 C3 25348397 N/A physical interaction ComPPI
KRTAP10-8 C3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EFEMP2 C3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AGR2 C3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAD21 C3 25348397 N/A physical interaction ComPPI
KRT31 C3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CTSG C3 14525934 1861080 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
OLFM4 C3 14525934 25348397 2824652 N/A experimental interaction detection,in vitro ComPPI,HPRD
TGM2 C3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAPPA C3 14525934 25348397 27898060 6203109 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
LRP1 C3 10608878 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGB2 C3 25348397 N/A physical interaction ComPPI
C3 CFP 11513971 14525934 25348397 27898060 3421908 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
C3 CFHR3 10622723 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
C3 CR1 10382758 14525934 25348397 9988761 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
C3 CR2 11684127 14525934 1830068 19164292 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
C3 CD46 14525934 1717583 23086448 24234451 25348397 N/A experimental interaction detection,enzyme linked immunosorbent assay,in vitro ComPPI,HPRD,IntAct
C3 ITGAM 11073102 14525934 25348397 4062888 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
C3 CFH 11367533 14525934 21317894 24234451 25348397 9988761 N/A experimental interaction detection,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,solid phase assay,surface plasmon resonance array ComPPI,HPRD,IntAct
C3 CFB 10610782 11367533 14525934 19255449 24234451 25348397 8648130 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
C3 GC 14525934 25348397 2824652 N/A experimental interaction detection,in vitro ComPPI,HPRD
C3 LAMA1 14525934 25348397 27898060 3488995 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
C3 ITGAX 14525934 25348397 7512600 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
C3 MASP1 11527969 14525934 25348397 27898060 9719152 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
C3 C3AR1 11342658 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
C3 CFHR4 10622723 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
C3 CFHR5 11058592 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
C3 CPN1 11939578 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
C3 C5AR2 11773063 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
C3 CFI 1401896 14525934 25348397 9291131 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
C3 FN1 25348397 N/A physical interaction ComPPI
C3 GDPD1 25348397 N/A physical interaction ComPPI
C3 ASCC1 25348397 N/A physical interaction ComPPI
C3 HNRNPA1 25348397 N/A physical interaction ComPPI
C3 MED4 25348397 N/A physical interaction ComPPI
C3 MED20 25348397 N/A physical interaction ComPPI
C3 MED23 25348397 N/A physical interaction ComPPI
C3 DDX31 25348397 N/A physical interaction ComPPI
C3 SNX27 25348397 N/A physical interaction ComPPI
C3 CDK15 25348397 N/A physical interaction ComPPI
C3 ZSCAN20 25348397 N/A physical interaction ComPPI
C3 TF 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
C3 CFTR 25348397 N/A physical interaction ComPPI
C3 VSIG4 14525934 16530040 17051150 25348397 27898060 N/A experimental interaction detection,fluorescence-activated cell sorting ComPPI,HPRD,OmniPath
C3 VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
C3 ASF1B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
C3 IGHM 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
C3 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C3 FAM20C 22582013 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
MAPK6 C3 25348397 N/A physical interaction ComPPI
C5 C3 11367533 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DDX19B C3 25348397 N/A physical interaction ComPPI
C3 C3 10622723 14525934 N/A experimental interaction detection HPRD
ABL1 C3 14525934 4062888 N/A experimental interaction detection HPRD
C2 C3 14525934 3546307 N/A experimental interaction detection HPRD
MAPT C3 24234451 26402096 association anti bait coimmunoprecipitation IntAct
C3 FH 21285368 27898060 N/A N/A OmniPath
CDK1 C3 10358196 1756717 27898060 N/A N/A OmniPath
C3 CD19 15454921 27898060 N/A N/A OmniPath
C3 C3AR1 11342658 20527893 27898060 stimulant N/A OmniPath
C3 ITGAX 12554829 27898060 4062888 7512600 7679388 stimulant N/A OmniPath
CFH C3 11367533 16023208 19050261 21317894 27898060 9291131 9988761 inhibition N/A OmniPath

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