GENE：C5AR1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | C5AR1 |
| FullNmae | complement C5a receptor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1338 |
| EnsembleID | ENSG00000197405 |
| Uniprot | P21730 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| C5AR1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| C5AR1 | GO:0001774,GO:0002430,GO:0004878,GO:0004878,GO:0004930,GO:0004930,GO:0005886,GO:0005886,GO:0006935,GO:0006954,GO:0006955,GO:0006968,GO:0007165,GO:0007200,GO:0007202,GO:0007204,GO:0007606,GO:0010575,GO:0010759,GO:0016323,GO:0030593,GO:0030667,GO:0032494,GO:0038178,GO:0042789,GO:0045177,GO:0045766,GO:0048143,GO:0050679,GO:0050830,GO:0050890,GO:0070374,GO:0090023,GO:0097242,GO:0099172,GO:1902947 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| C5AR1 | hsa:728 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| C5AR1 | hsa:728 | path:hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| C5AR1 | hsa:728 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| C5AR1 | hsa:728 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| C5AR1 | hsa:728 | path:hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| C5AR1 | hsa:728 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | C5AR1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | C5AR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKCD | C5AR1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCA | C5AR1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCB | C5AR1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCG | C5AR1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| GNAI1 | C5AR1 | 25361965 | interaction type | N/A | PTMCode2 |
| C5AR1 | GNAI1 | 25361965 | interaction type | N/A | PTMCode2 |
| C5 | C5AR1 | 25361965 | interaction type | N/A | PTMCode2 |
| C5AR1 | C5 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAI3 | C5AR1 | 25348397 | N/A | physical interaction | ComPPI |
| WAS | C5AR1 | 12600272 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| ARRB1 | C5AR1 | 12464600 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ARRB2 | C5AR1 | 12464600 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| C5 | C5AR1 | 14525934 25348397 9553099 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| C5AR1 | GNAI2 | 14525934 24234451 25241761 25348397 27898060 7962171 | physical association | experimental interaction detection,physical interaction,in vitro,proximity ligation assay | ComPPI,HPRD,IntAct,OmniPath |
| C5AR1 | C5AR2 | 11773063 14525934 17322907 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| RPS19 | C5AR1 | 11733378 14525934 | N/A | experimental interaction detection | HPRD |
| C5AR1 | C5AR1 | 14525934 8759762 9553099 | N/A | experimental interaction detection | HPRD |
| PRKCA | C5AR1 | 10636859 12464600 17145764 27898060 7642584 | N/A | N/A | OmniPath |
| PRKCB | C5AR1 | 17145764 27898060 | inhibition | N/A | OmniPath |
| PRKCD | C5AR1 | 10636859 12464600 17145764 27898060 | inhibition | N/A | OmniPath |
| GRK2 | C5AR1 | 27898060 7642584 | N/A | N/A | OmniPath |
| C5 | C5AR1 | 10602324 11773063 15661745 1847994 27898060 9553099 | stimulant | N/A | OmniPath |
| RPS19 | C5AR1 | 11107061 11733378 27898060 | N/A | N/A | OmniPath |