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GENE：CASP8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP8
FullNmae caspase 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1509
EnsembleID ENSG00000064012
Uniprot Q14790

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP8 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP8 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP8 necroptosis 27098859 The induction of apoptosis by CBN was correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, Bim and Bid, and the induction of necroptosis was related with RIP-3, and caspase-8. retulator signature
CASP8 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP8 mpt 11230742 MPT blockers, caspase-8 inhibition, and antioxidants prevented apoptosis and reduced ROS generation by hepatocytes. retulator signature
CASP8 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature retulator signature
CASP8 apoptosis 37625331 Much of this complexity arises from the diverse functions of caspase-8, a cysteine-aspartic acid protease typically associated with activating caspase-3 and - 7 to induce apoptosis. retulator signature
CASP8 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP8 GO:0001525,GO:0001817,GO:0004197,GO:0004197,GO:0005123,GO:0005164,GO:0005515,GO:0005654,GO:0005737,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0005829,GO:0005856,GO:0006508,GO:0006915,GO:0006915,GO:0006919,GO:0007507,GO:0008233,GO:0008233,GO:0008234,GO:0008625,GO:0010803,GO:0030101,GO:0030225,GO:0030225,GO:0031264,GO:0031265,GO:0031625,GO:0032025,GO:0032355,GO:0032496,GO:0032731,GO:0032991,GO:0034612,GO:0035877,GO:0035877,GO:0036462,GO:0042110,GO:0042113,GO:0042802,GO:0043065,GO:0043123,GO:0043123,GO:0043124,GO:0043525,GO:0044297,GO:0044877,GO:0045088,GO:0045471,GO:0045651,GO:0045862,GO:0051603,GO:0051603,GO:0051604,GO:0060546,GO:0060546,GO:0060715,GO:0070269,GO:0071260,GO:0071407,GO:0097110,GO:0097153,GO:0097153,GO:0097190,GO:0097190,GO:0097191,GO:0097194,GO:0097194,GO:0097199,GO:0097199,GO:0097199,GO:0097202,GO:0097264,GO:0097342

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP8 hsa:841 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
CASP8 hsa:841 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04210 Apoptosis - Homo sapiens (human)
CASP8 hsa:841 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
CASP8 hsa:841 path:hsa04217 Necroptosis - Homo sapiens (human)
CASP8 hsa:841 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CASP8 hsa:841 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
CASP8 hsa:841 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
CASP8 hsa:841 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CASP8 hsa:841 path:hsa05016 Huntington disease - Homo sapiens (human)
CASP8 hsa:841 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CASP8 hsa:841 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05132 Salmonella infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05134 Legionellosis - Homo sapiens (human)
CASP8 hsa:841 path:hsa05142 Chagas disease - Homo sapiens (human)
CASP8 hsa:841 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
CASP8 hsa:841 path:hsa05152 Tuberculosis - Homo sapiens (human)
CASP8 hsa:841 path:hsa05160 Hepatitis C - Homo sapiens (human)
CASP8 hsa:841 path:hsa05161 Hepatitis B - Homo sapiens (human)
CASP8 hsa:841 path:hsa05162 Measles - Homo sapiens (human)
CASP8 hsa:841 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05164 Influenza A - Homo sapiens (human)
CASP8 hsa:841 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
CASP8 hsa:841 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CASP8 hsa:841 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
CASP8 hsa:841 path:hsa05416 Viral myocarditis - Homo sapiens (human)
CASP8 hsa:841 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATG5 CASP8 11003656 15325588 17462996 20531300 23725295 24070470 26192618 26587781 26972597 28574505 9488730 interaction type N/A ACSN
FADD CASP8 11003656 12220669 15325588 16410793 17047155 17462996 20531300 23180781 23725295 24070470 26192618 26587781 26972597 28574505 9488730 9774341 interaction type,physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,gst pull down ACSN,InnateDB
TRIM13 CASP8 26192618 26587781 interaction type N/A ACSN
TRAF6 CASP8 16436380 16920630 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,gst pull down InnateDB
IKBKB CASP8 11002417 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 MAPK14 14970175 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
CASP8 CASP3 23180781 9208847 physical association anti tag coimmunoprecipitation InnateDB
CASP8 CFLAR 22421964 23180781 9208847 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TRAF1 11098060 23180781 cleavage reaction cleavage reaction InnateDB
TNFSF10 CASP8 10894161 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 CASP8 14993214 17036321 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF2 CASP8 17036321 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
H4C1 CASP8 17036321 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 FAS 12721308 17047155 17898872 22421964 23180781 9208847 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
CFLAR CASP8 12097160 15024054 17047155 23180781 9380701 cleavage reaction,physical association anti tag coimmunoprecipitation,protease assay InnateDB
CASP8 CHUK 11002417 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K14 CASP8 11002417 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK1 CASP8 11002417 17047155 18570872 21419663 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
COPS6 CASP8 17337451 23180781 cleavage reaction cleavage reaction InnateDB
DEDD2 CASP8 12527898 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 CASP8 10364179 10521396 16964285 21295084 23180781 26467481 9727492 9774341 interaction type,cleavage reaction,physical association,up-regulates activity,down-regulates activity gst pull down InnateDB,Signor
CASP8 DEDD 23180781 9774341 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
CASP8 TRAF2 17047155 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFT57 CASP8 17898872 23180781 physical association classical fluorescence spectroscopy InnateDB
CASP8 PLA2G4A 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
HDAC7 CASP8 18458084 23180781 cleavage reaction protease assay InnateDB
BID CASP8 18458084 23180781 cleavage reaction protease assay InnateDB
CASP3 CASP8 15014070 17179148 18458084 23180781 cleavage reaction,protein cleavage protease assay InnateDB
TNFRSF1A CASP8 15357952 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRC4 CASP8 12646168 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP CASP8 10409650 23180781 cleavage reaction protease assay InnateDB
ILK CASP8 16936772 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3R1 CASP8 18089778 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
FAS CASP8 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD11 CASP8 18625728 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPARC CASP8 17897953 23180781 physical association anti tag coimmunoprecipitation InnateDB
GZMB CASP8 15569669 17283187 19103589 23180781 protein cleavage protease assay InnateDB
IRF5 CASP8 19028697 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10A CASP8 10894161 17047155 17898872 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B CASP8 12721308 17047155 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
TRADD CASP8 15173123 17047155 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 CASP8 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG4D CASP8 19549685 23180781 cleavage reaction protease assay InnateDB
DDX58 CASP8 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 DDX3X 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
TANK CASP8 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
TBK1 CASP8 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS CASP8 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 FADD 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 CASP10 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TNFRSF10B 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TNFRSF10A 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TICAM1 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TLR3 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 RIPK1 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TRADD 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 BIRC3 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
PYCARD CASP8 23180781 24803432 physical association fluorescence microscopy InnateDB

Source Target Pmid Interactiontype Methods Database
BIRC2 CASP8 20005715 interaction type N/A PSP
FADD CASP8 20005715 interaction type N/A PSP
FAF1 CASP8 20005715 interaction type N/A PSP
KRT18 CASP8 20005715 interaction type N/A PSP
NOD1 CASP8 20005715 interaction type N/A PSP
SQSTM1 CASP8 20005715 interaction type N/A PSP
TRADD CASP8 20005715 interaction type N/A PSP
TRAF1 CASP8 20005715 interaction type N/A PSP
TRAF2 CASP8 20005715 interaction type N/A PSP
SQSTM1 CASP8 20005715 20005715 21071413 21628531 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 CASP8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CASP8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
IRF1 CASP8 17036321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
IRF2 CASP8 17036321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC CASP8 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 CASP8 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CASP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPD CASP8 24810056 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 CASP8 18342014 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 CASP8 20398055 trascriptional regulation,stimulation inferred by curator TFlink
MEN1 CASP8 17766243 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 CASP8 15930301 trascriptional regulation,stimulation inferred by curator TFlink
RELA CASP8 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 CASP8 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000013D17D CASP8 22197821 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000003ABC4 CASP8 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000600E6 CASP8 24166509 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000045147B CASP8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A3D CASP8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 CASP8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED CASP8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 CASP8 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A CASP8 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 CASP8 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 CASP8 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C CASP8 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 CASP8 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00001C3AC1 CASP8 25416803 27927008 mrna cleavage,inhibition rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D CASP8 25416803 26080425 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000085F64 CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000072E4C CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD231 CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000023F008 CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000CC005 CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000214763 CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EC1BE CASP8 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 CASP8 22135298 phosphorylation N/A PhosphoSite
SRC CASP8 22135298 phosphorylation N/A PhosphoSite
CDK1 CASP8 22135298 phosphorylation N/A PhosphoSite
MAPK14 CASP8 22135298 phosphorylation N/A PhosphoSite
MAPK1 CASP8 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK3 CASP8 22135298 phosphorylation N/A PhosphoSite
LYN CASP8 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 CASP8 22135298 phosphorylation N/A PhosphoSite
HIP1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 HIP1 25361965 interaction type N/A PTMCode2
RIPK2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 RIPK2 25361965 interaction type N/A PTMCode2
TRADD CASP8 25361965 interaction type N/A PTMCode2
CASP8 TRADD 25361965 interaction type N/A PTMCode2
BCL2L1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 BCL2L1 25361965 interaction type N/A PTMCode2
CASP8 MAPK1 25361965 interaction type N/A PTMCode2
CASP9 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP9 25361965 interaction type N/A PTMCode2
TNFSF10 CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFSF10 25361965 interaction type N/A PTMCode2
CASP2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP2 25361965 interaction type N/A PTMCode2
CASP10 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP10 25361965 interaction type N/A PTMCode2
CFLAR CASP8 25361965 interaction type N/A PTMCode2
CASP8 CFLAR 25361965 interaction type N/A PTMCode2
NOL3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 NOL3 25361965 interaction type N/A PTMCode2
CASP6 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP6 25361965 interaction type N/A PTMCode2
IFT57 CASP8 25361965 interaction type N/A PTMCode2
CASP8 IFT57 25361965 interaction type N/A PTMCode2
GMEB1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 GMEB1 25361965 interaction type N/A PTMCode2
TNFAIP3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFAIP3 25361965 interaction type N/A PTMCode2
VIM CASP8 25361965 interaction type N/A PTMCode2
CASP8 VIM 25361965 interaction type N/A PTMCode2
EIF2AK2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 EIF2AK2 25361965 interaction type N/A PTMCode2
RIPK3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 RIPK3 25361965 interaction type N/A PTMCode2
RALBP1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 RALBP1 25361965 interaction type N/A PTMCode2
CASP3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP3 25361965 interaction type N/A PTMCode2
BCL2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 BCL2 25361965 interaction type N/A PTMCode2
EZR CASP8 25361965 interaction type N/A PTMCode2
CASP8 EZR 25361965 interaction type N/A PTMCode2
CDKN1B CASP8 25361965 interaction type N/A PTMCode2
CASP8 CDKN1B 25361965 interaction type N/A PTMCode2
CDH1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CDH1 25361965 interaction type N/A PTMCode2
MACF1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 MACF1 25361965 interaction type N/A PTMCode2
APP CASP8 25361965 interaction type N/A PTMCode2
CASP8 APP 25361965 interaction type N/A PTMCode2
FADD CASP8 25361965 interaction type N/A PTMCode2
CASP8 FADD 25361965 interaction type N/A PTMCode2
RIPK1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 RIPK1 25361965 interaction type N/A PTMCode2
TNFRSF10A CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFRSF10A 25361965 interaction type N/A PTMCode2
CASP8 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 CASP8 25361965 interaction type N/A PTMCode2
CASP8 PEA15 25361965 interaction type N/A PTMCode2
PEA15 CASP8 25361965 interaction type N/A PTMCode2
CASP8 FASLG 25361965 interaction type N/A PTMCode2
FASLG CASP8 25361965 interaction type N/A PTMCode2
CASP8 DEDD 25361965 interaction type N/A PTMCode2
DEDD CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFAIP8L2 25361965 interaction type N/A PTMCode2
TNFAIP8L2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CHUK 25361965 interaction type N/A PTMCode2
CHUK CASP8 25361965 interaction type N/A PTMCode2
CASP8 AR 25361965 interaction type N/A PTMCode2
AR CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP4 25361965 interaction type N/A PTMCode2
CASP4 CASP8 25361965 interaction type N/A PTMCode2
TNFRSF1A CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFRSF1A 25361965 interaction type N/A PTMCode2
BIRC2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 BIRC2 25361965 interaction type N/A PTMCode2
CTNNB1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CTNNB1 25361965 interaction type N/A PTMCode2
BID CASP8 25361965 interaction type N/A PTMCode2
CASP8 BID 25361965 interaction type N/A PTMCode2
XIAP CASP8 25361965 interaction type N/A PTMCode2
CASP8 XIAP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 CASP8 10891503 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RALBP1 CASP8 14525934 16227629 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AGR3 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GMNN CASP8 25348397 N/A physical interaction ComPPI
CRYAB CASP8 25348397 N/A physical interaction ComPPI
VIM CASP8 10469173 11423904 14525934 16169070 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo ComPPI,HPRD,IntAct
TNFAIP3 CASP8 19060883 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
S100A14 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN1B CASP8 11420686 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CASP14 CASP8 14525934 25348397 9792675 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF6 CASP8 25348397 N/A physical interaction ComPPI
XIAP CASP8 25348397 N/A physical interaction ComPPI
CASP9 CASP8 25348397 N/A physical interaction ComPPI
RYBP CASP8 11395500 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2D1 CASP8 19427028 24234451 25348397 ubiquitination reaction enzymatic study ComPPI,IntAct
PTPN6 CASP8 18086677 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
OPTN CASP8 25348397 N/A physical interaction ComPPI
MAP1LC3B CASP8 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FIS1 CASP8 21183955 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2L1 CASP8 11733517 14525934 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BEX1 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRDM14 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ERRFI1 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK1 CASP8 14525934 17290218 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MAPK8 CASP8 25348397 N/A physical interaction ComPPI
CASP3 CASP8 11437602 14525934 18669646 24234451 25348397 N/A experimental interaction detection,physical interaction,protease assay,in vitro,in vivo ComPPI,HPRD,IntAct
MAPK3 CASP8 14525934 17290218 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
KHDRBS1 CASP8 25348397 N/A physical interaction ComPPI
RB1 CASP8 14525934 15735701 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AR CASP8 14525934 17170703 24234451 25348397 physical association experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct
SUMO1 CASP8 14525934 15782135 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TSC22D3 CASP8 25348397 N/A physical interaction ComPPI
PIAS1 CASP8 14525934 15782135 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MAPK14 CASP8 25348397 N/A physical interaction ComPPI
CEBPB CASP8 25348397 N/A physical interaction ComPPI
UBE2L3 CASP8 19427028 24234451 25348397 ubiquitination reaction enzymatic study ComPPI,IntAct
SORBS1 CASP8 25348397 N/A physical interaction ComPPI
RHOA CASP8 25348397 N/A physical interaction ComPPI
ARHGDIA CASP8 25348397 N/A physical interaction ComPPI
SPP1 CASP8 25348397 N/A protease assay,protein cleavage ComPPI
SRF CASP8 11387340 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CUL3 CASP8 19427028 24234451 25348397 ubiquitination reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,enzymatic study ComPPI,IntAct
MAP4K4 CASP8 25348397 N/A in vivo ComPPI
PDIA6 CASP8 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBB CASP8 19427028 24234451 25348397 ubiquitination reaction enzymatic study ComPPI,IntAct
UBC CASP8 25348397 N/A physical interaction ComPPI
PICALM CASP8 10926122 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
USO1 CASP8 25348397 N/A in vitro,in vivo ComPPI
FAF1 CASP8 12702723 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDH1 CASP8 25348397 N/A in vivo ComPPI
SPARC CASP8 25348397 N/A coimmunoprecipitation ComPPI
CASP1 CASP8 25348397 N/A physical interaction ComPPI
YBX1 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EIF2AK2 CASP8 11555640 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 CASP8 12232792 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ILK CASP8 14525934 16936772 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PARP1 CASP8 25348397 N/A physical interaction ComPPI
PARP2 CASP8 12065591 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
HSPA5 CASP8 19632185 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
CASP7 CASP8 25348397 N/A physical interaction ComPPI
CASP8 GMEB1 14525934 16497673 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
CASP8 EDA2R 25348397 N/A coimmunoprecipitation,in vitro ComPPI
CASP8 BCAP31 12668660 14525934 21183955 24234451 25348397 9334338 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CASP8 CHUK 11002417 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP8 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP8 PLEC 10891503 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP8 TRAF1 11098060 11181075 12887920 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP8 APAF1 14525934 25348397 9539746 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP8 FADD 11717445 12107169 12887920 14525934 14612908 17047155 17159907 17290218 18485876 19060883 19176810 19524512 20103630 21458669 21525013 21785459 21988832 22173242 22274400 23955153 24234451 25043603 25348397 25911380 30561431 8681376 9343261 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid,virotrap ComPPI,HPRD,IntAct
CASP8 IKBKB 11002417 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP8 PEA15 10442631 10493725 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP8 RIPK1 10521396 11002417 12215447 12884866 12887920 14525934 17047155 18485876 19060883 19524512 19524513 21458669 21525013 22173242 22274400 23955153 24234451 25348397 25911380 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP8 CRADD 11002417 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP8 RIPK2 14525934 25348397 9575181 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP8 TNFRSF10A 12218097 14525934 17047155 19427028 20103630 21785459 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
CASP8 TNFRSF10B 12218097 14525934 17047155 20103630 24234451 25043603 25348397 colocalization,association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
CASP8 NR1H4 25348397 N/A physical interaction,in vitro ComPPI
CASP8 NOL3 14525934 18245485 24234451 25348397 27898060 9560245 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CASP8 NOD1 10329646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP8 DEDD 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP8 CASP8AP2 10235259 11340079 14525934 17245429 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
CASP8 DEDD2 11965497 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP8 BFAR 10716992 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP8 CTNNB1 12189238 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP8 HIP1 11788820 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP8 CDK11A 25348397 N/A in vivo ComPPI
CASP8 FYN 10435619 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP8 PCYT1A 12052891 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP8 TRAF2 11340079 12887920 14525934 16227629 17047155 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP8 PRKN 12692130 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP8 CDK11B 25348397 N/A in vitro ComPPI
CASP8 STK24 12107159 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP8 CASP10 11717445 12198154 12887920 14525934 170210 17159907 24234451 25348397 3031469 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP8 PRKCZ 11016947 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP8 TFCP2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CASP8 TOPORS 14525934 17290218 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
CASP8 FAS 11101867 11717445 12887920 14525934 16498403 17047155 17159907 18328427 21625644 21803845 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
CASP8 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP8 BCL2 11406564 14525934 16183855 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CASP8 MAPT 25348397 N/A in vitro,in vivo ComPPI
CASP8 FASLG 12198154 12887920 16498403 24025841 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CASP8 BID 11085743 12097160 12196516 14525934 25348397 9727491 9727492 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CASP8 EZR 25348397 N/A physical interaction ComPPI
CASP8 MSN 25348397 N/A physical interaction ComPPI
CASP8 TNFRSF1A 21157428 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
CASP8 TRADD 12887920 17047155 19524513 24234451 25348397 30561431 association anti bait coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
CASP8 BIRC2 12887920 22274400 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP8 CHD3 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CASP8 IFT57 25348397 N/A physical interaction ComPPI
CASP8 CASP4 25348397 N/A physical interaction ComPPI
CASP8 HDAC7 25348397 N/A physical interaction ComPPI
CASP8 RALGDS 25348397 N/A physical interaction ComPPI
CASP8 NLRC4 25348397 N/A physical interaction ComPPI
CASP8 PTEN 25348397 N/A physical interaction ComPPI
CASP8 USP2 25348397 N/A physical interaction ComPPI
CASP8 MAP1LC3A 25348397 N/A physical interaction ComPPI
CASP8 SQSTM1 19427028 21576355 21628531 24121507 24234451 25348397 27898060 colocalization,association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
CASP8 TNFSF10 10894160 12198154 16801533 19427028 20097879 21459798 21525171 21822306 22266862 23678861 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
CASP8 COPS6 25348397 N/A physical interaction ComPPI
CASP8 CLIP3 25348397 N/A physical interaction ComPPI
CASP8 BIRC6 25348397 N/A physical interaction ComPPI
CASP8 RNF34 15069192 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CASP8 TP53 25348397 N/A physical interaction ComPPI
CASP8 LRRK2 25348397 N/A physical interaction ComPPI
CASP8 CARD11 25348397 N/A physical interaction ComPPI
CASP8 PARK7 25348397 N/A physical interaction ComPPI
CASP8 RIPK3 19524512 19524513 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP8 PLA2G4B 25348397 N/A physical interaction ComPPI
CASP8 SNRPD3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP8 PLIN4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP8 GZMB 25348397 N/A physical interaction ComPPI
CASP8 HECTD3 25348397 N/A physical interaction ComPPI
CASP8 TNF 25348397 N/A physical interaction ComPPI
CASP8 PRDX6 25348397 N/A physical interaction ComPPI
CASP8 BAX 25348397 N/A physical interaction ComPPI
CASP8 ERLIN2 25348397 N/A physical interaction ComPPI
CASP8 TICAM1 25348397 N/A physical interaction ComPPI
CASP8 BIRC3 25348397 N/A physical interaction ComPPI
CASP8 ATG4D 25348397 N/A physical interaction ComPPI
CASP8 ANGPTL4 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 ATAD2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 BAP1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 BLID 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 CASC3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 CDH13 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 EPSTI1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 GLCE 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 GREB1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 IL13RA2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 IL24 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 KLK5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 KLK9 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 LYPD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 PSMC3IP 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 SCGB2A2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 SERPINB5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 ST14 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 PRSS50 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 VPS45 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 NSD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 ATP1A3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 BCL2L10 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 CNBP 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 HBP1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 QDPR 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 UMPS 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 BLM 25348397 N/A physical interaction ComPPI
CASP8 MLKL 25348397 N/A physical interaction ComPPI
CASP8 TLR3 25348397 N/A physical interaction ComPPI
CASP8 PPP2CA 25348397 N/A physical interaction ComPPI
CASP8 NCL 17290218 24234451 25348397 colocalization imaging technique ComPPI,IntAct
CASP8 NUCB2 18154733 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP8 OTUD7B 19427028 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP8 UBE2V1 19427028 24234451 25348397 ubiquitination reaction enzymatic study ComPPI,IntAct
CASP8 SMPD1 21157428 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
CASP8 MALT1 22267217 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
CASP8 CARD9 22267217 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CASP8 PYCARD 22267217 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CASP8 PARP10 23305266 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP8 RFFL 15069192 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
CASP8 TMEM219 20353938 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SOX2 CASP8 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKCI CASP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP3K14 CASP8 11002417 12884866 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
CASP2 CASP8 25348397 N/A physical interaction ComPPI
CFLAR CASP8 12097160 12215447 12887920 14525934 17047155 17159907 24234451 24438025 25348397 9208847 9289491 9380701 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,protease assay,in vitro,in vivo,protein cleavage ComPPI,HPRD,IntAct
NUCB1 CASP8 18154733 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
BCL10 CASP8 22267217 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SERPINB9 CASP8 25348397 N/A physical interaction ComPPI
CASP8 GRIA1 11751897 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
IKBKG CASP8 14525934 16227629 N/A experimental interaction detection HPRD
CASP8 CASP8 11717445 14525934 16169070 17170703 17290218 24234451 8681376 physical association experimental interaction detection,fluorescent resonance energy transfer,pull down,two hybrid pooling approach,two hybrid HPRD,IntAct
CASP8 APP 10911620 14525934 N/A experimental interaction detection HPRD
IFT57 CASP8 17898872 27898060 N/A N/A OmniPath
SRC CASP8 16619028 18089778 18216014 18974049 19851329 27898060 inhibition N/A OmniPath
LYN CASP8 18086677 27898060 N/A N/A OmniPath
IRF1 CASP8 14993214 19129219 27898060 stimulant N/A OmniPath
CHUK CASP8 11002417 27898060 N/A N/A OmniPath
TRAF2 CASP8 11340079 12887920 16227629 17047155 21282461 22179575 22421964 23142077 27898060 stimulant N/A OmniPath
CASP8 TRAF2 11340079 12887920 16227629 17047155 21282461 22179575 22421964 23142077 27898060 N/A N/A OmniPath
ABL2 CASP8 18458084 27898060 N/A N/A OmniPath
CASP8 ABL2 18458084 27898060 N/A N/A OmniPath
CASP8 CASP8AP2 10235259 11340079 17245429 27898060 stimulant N/A OmniPath
CASP8AP2 CASP8 10235259 11340079 17245429 27898060 stimulant N/A OmniPath
FADD CASP8 11717445 12107169 12220669 12702723 12887920 12911633 14612908 15280356 15659383 16410793 16469705 17047155 17159907 17290218 18485876 18708583 18946037 19060883 20448643 20829884 21458669 21525013 21620750 21737329 21737330 21785459 21988832 22179575 22274400 22421964 22864571 23142077 23972990 25043603 25911380 25939870 26437781 27898060 8681376 8681377 9228018 9343261 9774341 stimulant N/A OmniPath
CASP8 FADD 11717445 12107169 12220669 12702723 12887920 12911633 14612908 15280356 15659383 16410793 16469705 17047155 17159907 17290218 18485876 18708583 18946037 19060883 20448643 20829884 21458669 21525013 21620750 21737329 21737330 21785459 21988832 22179575 22274400 22421964 22864571 23142077 23972990 25043603 25911380 25939870 26437781 27898060 8681376 9228018 9343261 9774341 N/A N/A OmniPath
CASP8 EIF2AK2 11555640 27898060 N/A N/A OmniPath
GZMB CASP8 15569669 17283187 19103589 27898060 stimulant N/A OmniPath
CASP8 CASP7 10872455 11832478 18073771 18329793 27898060 8962078 9463409 9545235 9727491 stimulant N/A OmniPath
CASP8 MAP3K14 10753878 11002417 12884866 27898060 stimulant N/A OmniPath
MAP3K14 CASP8 11002417 12884866 27898060 N/A N/A OmniPath
CASP3 CASP8 11437602 11832478 15014070 15254227 17179148 18458084 18669646 27898060 8962078 9208847 9765224 9922454 stimulant N/A OmniPath
CASP8 CASP3 11437602 11832478 15014070 15254227 16964285 17179148 18458084 18669646 21295084 27898060 8962078 9208847 9501089 9765224 9885230 9922454 9950028 stimulant N/A OmniPath
BID CASP8 11085743 11832478 12097160 12196516 15659383 18458084 27898060 9727491 9727492 N/A N/A OmniPath
CASP8 BID 11085743 11832478 12097160 12196516 15659383 18458084 27898060 9727491 9727492 9873064 stimulant N/A OmniPath
CASP8 CASP9 10988287 11832478 27898060 8962078 stimulant N/A OmniPath
CASP8 APP 10409650 10911620 27898060 stimulant N/A OmniPath
CASP8 TRAF6 16436380 16920630 27898060 N/A N/A OmniPath
TNFRSF10B CASP8 11940602 12218097 12721308 15388581 15659383 17047155 19343040 22421964 23142077 26186194 27898060 9325248 stimulant N/A OmniPath
CASP8 TNFRSF10B 11940602 12218097 12721308 15388581 15659383 17047155 19343040 22421964 23142077 26186194 27898060 9325248 N/A N/A OmniPath
MAVS CASP8 16406812 21419663 27898060 stimulant N/A OmniPath
PTPN6 CASP8 18086677 27898060 inhibition,stimulant N/A OmniPath
CASP8 COPS6 17337451 27898060 N/A N/A OmniPath
COPS6 CASP8 17337451 27898060 N/A N/A OmniPath
MAPK3 CASP8 17290218 24342355 27898060 inhibition N/A OmniPath
CASP2 CASP8 11832478 15262979 16193064 27898060 8962078 stimulant N/A OmniPath
CASP8 CYCS 10364179 27898060 stimulant N/A OmniPath
CASP8 TRADD 12887920 14585074 15173123 17047155 18776134 22421964 27898060 N/A N/A OmniPath
TRADD CASP8 12887920 14585074 15173123 17047155 18776134 22421964 27898060 stimulant N/A OmniPath
MAPK14 CASP8 14970175 27898060 inhibition N/A OmniPath
PIK3R1 CASP8 18089778 27898060 N/A N/A OmniPath
CDK1 CASP8 20937773 24484936 26036637 27898060 inhibition N/A OmniPath
CASP8 CASP10 11717445 11832478 12198154 12887920 15280356 15659383 170210 17159907 21737330 22421964 22864571 27898060 3031469 8962078 stimulant N/A OmniPath
CASP10 CASP8 11717445 11832478 12198154 12887920 15280356 15659383 170210 17159907 21737330 22421964 22864571 27898060 3031469 8962078 N/A N/A OmniPath
FAS CASP8 10196099 11101867 12721308 15659383 15993755 16498403 17047155 17159907 17898872 18328427 22421964 26186194 27898060 9208847 9325248 stimulant N/A OmniPath
CASP8 FAS 10196099 11101867 12721308 15659383 15993755 16498403 17047155 17159907 17898872 18328427 22421964 26186194 27898060 9208847 9325248 N/A N/A OmniPath
CASP6 CASP8 11455969 11832478 12232792 27898060 8962078 9727491 stimulant N/A OmniPath
CASP8 CASP6 11455969 11832478 12232792 18329793 27898060 8962078 9727491 stimulant N/A OmniPath
MAPK1 CASP8 17290218 24342355 27898060 inhibition N/A OmniPath
CASP8 ATG4D 19549685 27898060 N/A N/A OmniPath
TNFSF10 CASP8 10894161 21822306 22266862 22585859 23142077 23678861 24287696 27898060 stimulant N/A OmniPath
CASP8 TNFSF10 10894161 21822306 22266862 22585859 23142077 23678861 24287696 27898060 N/A N/A OmniPath
DDX58 CASP8 21419663 27898060 N/A N/A OmniPath
CASP8 VIM 10469173 11423904 16169070 27898060 N/A N/A OmniPath
CARD11 CASP8 18625728 27898060 N/A N/A OmniPath
CASP8 NLRC4 12646168 27898060 N/A N/A OmniPath
CASP8 PSEN1 10069390 27898060 N/A N/A OmniPath
RIPK1 CASP8 10521396 11002417 11002422 12215447 12884866 12887920 17047155 18570872 19060883 19373245 19773432 20825417 21282461 21419663 21458669 21525013 21737329 21737330 22179575 22274400 22421964 22585859 22864571 23972990 24577083 25911380 25939870 27898060 stimulant N/A OmniPath
CASP8 RIPK1 10469655 10521396 11002417 11002422 11042193 12215447 12842894 12884866 12887920 17047155 18570872 19060883 19373245 19773432 20825417 21282461 21419663 21458669 21525013 21737329 21737330 22179575 22274400 22421964 22585859 22864571 23972990 24577083 25911380 25939870 27898060 8657102 inhibition N/A OmniPath
TNFRSF1A CASP8 12887920 15357952 15725726 21157428 27898060 8875942 stimulant N/A OmniPath
CASP8 TNFRSF1A 15357952 21157428 27898060 N/A N/A OmniPath
CASP8 TP73 18362891 27898060 stimulant N/A OmniPath
CFLAR CASP8 11741985 12097160 12215447 12887920 14585074 15024054 15280356 17047155 17159907 19343040 19416807 19710364 21737329 21737330 22322857 22421964 22864571 24438025 26186194 27898060 9208847 9217161 9228018 9289491 9326610 9380701 9794838 9880531 inhibition N/A OmniPath
CASP8 CFLAR 11741985 12097160 12215447 12887920 15024054 15280356 17047155 17159907 19343040 19416807 19710364 21737329 21737330 22322857 22421964 22864571 24438025 26186194 27898060 9208847 9228018 9289491 9326610 9380701 9794838 N/A N/A OmniPath
CASP8 TBK1 21419663 27898060 N/A N/A OmniPath
IKBKB CASP8 11002417 27898060 N/A N/A OmniPath
TNFRSF10A CASP8 10894161 12218097 15280356 15388581 17047155 17898872 19343040 19427028 21785459 22421964 23142077 27898060 9325248 stimulant N/A OmniPath
CASP8 TANK 21419663 27898060 N/A N/A OmniPath
CASP8 PLEC 10891503 27898060 N/A N/A OmniPath
CASP8 TRAF1 11098060 11181075 12709429 12887920 27898060 stimulant N/A OmniPath
CASP8 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
PLA2G4A CASP8 27898060 9875225 N/A N/A OmniPath
SPARC CASP8 17897953 27898060 N/A N/A OmniPath
ILK CASP8 16936772 27898060 N/A N/A OmniPath
CASP8 DDX3X 21419663 27898060 N/A N/A OmniPath
CASP8 HDAC7 18458084 27898060 stimulant N/A OmniPath
DEDD CASP8 11965497 12527898 27898060 9774341 N/A N/A OmniPath
CASP8 DEDD 11965497 12527898 27898060 9774341 stimulant N/A OmniPath
DEDD2 CASP8 11965497 12527898 27898060 N/A N/A OmniPath
CASP8 PROKR1 11555640 27898060 inhibition N/A OmniPath
BCAP31 CASP8 11917123 12668660 15254227 21183955 27898060 9334338 inhibition N/A OmniPath
CASP8 BCAP31 11917123 12668660 15254227 21183955 27898060 9334338 N/A N/A OmniPath
CASP8 PCYT1A 12052891 27898060 N/A N/A OmniPath
BFAR CASP8 10716992 11733517 27898060 inhibition N/A OmniPath

Visualization










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