Gene Information gene info

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GENE：CAST

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CAST
FullNmae calpastatin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1515
EnsembleID ENSG00000153113
Uniprot P20810

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CAST immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CAST GO:0003723,GO:0004866,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0005829,GO:0010859,GO:0010859,GO:0016020,GO:0045296,GO:0097340,GO:0097340,GO:1990709,GO:2000675

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CAST hsa:831 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PLCG1 CAST 17474147 23180781 physical association peptide array InnateDB
CAST CAST 25969760 26467481 bind,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR CAST 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 CAST 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 CAST 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CAST 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 CAST 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CAST 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 CAST 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CAST 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 CAST 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000153377 CAST 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FD1A CAST 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CAST CARD16 25361965 interaction type N/A PTMCode2
CARD16 CAST 25361965 interaction type N/A PTMCode2
CAPN1 CAST 25361965 interaction type N/A PTMCode2
CAST CAPN1 25361965 interaction type N/A PTMCode2
CASP7 CAST 25361965 interaction type N/A PTMCode2
CAST CASP7 25361965 interaction type N/A PTMCode2
CASP3 CAST 25361965 interaction type N/A PTMCode2
CAST CASP3 25361965 interaction type N/A PTMCode2
CAPN2 CAST 25361965 interaction type N/A PTMCode2
CAST CAPN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KIF5B CAST 25348397 N/A physical interaction ComPPI
PPFIA1 CAST 12923177 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CRK CAST 17474147 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
PIK3R1 CAST 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SRC CAST 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NCK1 CAST 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CASP3 CAST 14525934 25348397 9705209 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRB2 CAST 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
COPS5 CAST 25348397 N/A physical interaction ComPPI
CDH1 CAST 25348397 N/A physical interaction ComPPI
CASP1 CAST 14525934 25348397 9705209 N/A experimental interaction detection,in vitro ComPPI,HPRD
BAG6 CAST 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 CAST 25348397 N/A physical interaction ComPPI
PSMA5 CAST 25348397 N/A physical interaction ComPPI
CASP7 CAST 10731697 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPL CAST 25348397 N/A physical interaction ComPPI
CFTR CAST 25348397 N/A physical interaction ComPPI
PPFIA2 CAST 12923177 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PPFIA3 CAST 12923177 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
EPB41L1 CAST 25348397 N/A physical interaction ComPPI
CUL4A CAST 25348397 N/A physical interaction ComPPI
COPS4 CAST 25348397 N/A physical interaction ComPPI
PSIP1 CAST 25348397 N/A physical interaction ComPPI
FYN CAST 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SART3 CAST 25348397 N/A physical interaction ComPPI
CAPN2 CAST 18519038 24234451 25348397 physical association nuclear magnetic resonance ComPPI,IntAct
PSMB5 CAST 25348397 N/A physical interaction ComPPI
CAST CAPN1 12684003 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CAST PPFIA4 25348397 N/A two hybrid,in vitro ComPPI
CAST HTRA1 14525934 15101818 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CAST PCLAF 25348397 N/A physical interaction ComPPI
CAST ELAVL1 25348397 N/A physical interaction ComPPI
CAST LRBA 25348397 N/A physical interaction ComPPI
CAST PSMB7 25348397 N/A physical interaction ComPPI
CAST RPP38 25348397 N/A physical interaction ComPPI
CAST PPP4R3A 25348397 N/A physical interaction ComPPI
CAST FNTB 25348397 N/A physical interaction ComPPI
CAST CAPNS2 25348397 N/A physical interaction ComPPI
CAST NUDC 25348397 N/A physical interaction ComPPI
CAST LZIC 25348397 N/A physical interaction ComPPI
CAST PPME1 25348397 N/A physical interaction ComPPI
CAST CAPN8 25348397 N/A physical interaction ComPPI
CAST MTUS2 25348397 N/A physical interaction ComPPI
CAST ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CAST PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CAST EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PSMB3 CAST 25348397 N/A physical interaction ComPPI
CAPNS1 CAST 12684003 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CKB CAST 25348397 N/A physical interaction ComPPI
PLGRKT CAST 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NCL CAST 24234451 30021884 physical association cross-linking study IntAct
HMGN2 CAST 24234451 30021884 physical association cross-linking study IntAct
RSL1D1 CAST 24234451 30021884 physical association cross-linking study IntAct
SRC CAST 17474147 1995645 27898060 N/A N/A OmniPath
CAST CAPN3 25969760 27898060 inhibition N/A OmniPath
CAST CAPN1 12684003 20679491 25969760 26496610 27898060 inhibition N/A OmniPath
CAST CAPN2 25969760 27898060 inhibition N/A OmniPath

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