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GENE：CCL21

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCL21
FullNmae C-C motif chemokine ligand 21
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10620
EnsembleID ENSG00000137077
Uniprot O00585

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCL21 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CCL21 GO:0001768,GO:0001771,GO:0001954,GO:0002407,GO:0002548,GO:0002606,GO:0005515,GO:0005576,GO:0005615,GO:0006954,GO:0006954,GO:0006955,GO:0007186,GO:0007186,GO:0007267,GO:0008009,GO:0008009,GO:0008009,GO:0010560,GO:0010820,GO:0030593,GO:0030838,GO:0031274,GO:0031295,GO:0031529,GO:0031732,GO:0033630,GO:0034695,GO:0035759,GO:0038116,GO:0042379,GO:0043123,GO:0043547,GO:0043552,GO:0045860,GO:0046330,GO:0048020,GO:0048247,GO:0048260,GO:0048469,GO:0050921,GO:0051209,GO:0051491,GO:0051897,GO:0060326,GO:0070098,GO:0070374,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:0090023,GO:0090630,GO:0097026,GO:1903237,GO:1990869,GO:2000147,GO:2000406,GO:2000529,GO:2000548,GO:2000669

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCL21 hsa:6366 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CCL21 hsa:6366 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CCL21 hsa:6366 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
CCL21 hsa:6366 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ACKR4 CCL21 10706668 23180781 physical association competition binding InnateDB
CTSD CCL21 12651610 23180781 protein cleavage cleavage assay InnateDB
CCR7 CCL21 22221265 23180781 9507024 physical association competition binding,solution state nmr InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 CCL21 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF CCL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CCL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CCL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB2 CCL21 20953353 trascriptional regulation,stimulation inferred by curator TFlink
RELB CCL21 20953353 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CCR7 CCL21 25361965 interaction type N/A PTMCode2
CCL21 CCR7 25361965 interaction type N/A PTMCode2
CCL21 CXCL13 25361965 interaction type N/A PTMCode2
CXCL13 CCL21 25361965 interaction type N/A PTMCode2
CCL21 IGFBP7 25361965 interaction type N/A PTMCode2
IGFBP7 CCL21 25361965 interaction type N/A PTMCode2
CCL21 CCR10 25361965 interaction type N/A PTMCode2
CCR10 CCL21 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CXCL9 CCL21 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CTSD CCL21 12651610 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PF4 CCL21 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL21 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
IGFBP7 CCL21 12847218 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TRIP6 CCL21 25348397 N/A physical interaction ComPPI
ACKR2 CCL21 10706668 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CCL13 CCL21 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL12 CCL21 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
ACKR4 CCL21 10706668 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBQLN4 CCL21 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
CCL17 CCL21 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CXCL11 CCL21 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCR7 CCL21 14525934 21172016 24234451 25348397 9507024 9585422 physical association experimental interaction detection,physical interaction,biochemical,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CXCL13 CCL21 14525934 15546958 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CCL28 CCL21 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 VCAN 11083865 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CCL21 GOT2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCL21 CLTCL1 25348397 N/A physical interaction ComPPI
CCL21 KLHL26 25348397 N/A physical interaction ComPPI
CCL21 KLHL22 25348397 N/A physical interaction ComPPI
CCL21 A1BG 25348397 N/A physical interaction,biochemical ComPPI
CCL21 LRRK1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CCL21 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CCL21 TMEM107 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCL21 TTMP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCL21 OTP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCL21 PPBP 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 XCL1 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CCL26 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CCL23 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 PF4V1 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CCL24 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CXCL10 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CXCL17 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
XCL2 CCL21 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL14 CCL21 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
SMARCB1 CCL21 24234451 30021884 physical association cross-linking study IntAct
HNRNPA2B1 CCL21 24234451 30021884 physical association cross-linking study IntAct
CTSD CCL21 12651610 27898060 N/A N/A OmniPath
CCL21 CXCR3 11907075 27898060 stimulant N/A OmniPath
CCL21 ACKR4 10706668 23341447 24218476 27898060 N/A N/A OmniPath
CCL21 CCR7 10488147 11970971 21172016 22221265 24218476 27898060 9507024 9585422 stimulant N/A OmniPath
CCR7 CCL21 10488147 21172016 22221265 27898060 9507024 9585422 N/A N/A OmniPath

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