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GENE：CCL7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCL7
FullNmae C-C motif chemokine ligand 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10634
EnsembleID ENSG00000108688
Uniprot P80098

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCL7 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CCL7 GO:0002548,GO:0002548,GO:0005515,GO:0005576,GO:0005615,GO:0006874,GO:0006935,GO:0006954,GO:0007010,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0008009,GO:0008201,GO:0008360,GO:0030335,GO:0030593,GO:0031726,GO:0043547,GO:0048020,GO:0048245,GO:0048245,GO:0048247,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:2000503

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCL7 hsa:6354 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CCL7 hsa:6354 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CCL7 hsa:6354 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
CCL7 hsa:6354 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CCR5 CCL7 10477718 23180781 physical association competition binding InnateDB
CCR1 CCL7 12381680 23180781 7545673 8530354 physical association competition binding InnateDB
CTNNB1 CCL7 11118053 23180781 physical association electrophoretic mobility supershift assay InnateDB
MMP2 CCL7 10947989 23180781 physical association two hybrid InnateDB
CCR3 CCL7 23180781 8642344 physical association competition binding InnateDB
ACKR2 CCL7 23180781 9405404 physical association competition binding InnateDB
CCR2 CCL7 23180781 7759884 8530354 9115216 physical association competition binding InnateDB
CCL7 ACKR4 10734104 23180781 physical association competition binding InnateDB
CCL7 BCL6 21801248 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL7 STAT6 21801248 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL7 NR3C1 21148795 23180781 physical association anti tag coimmunoprecipitation InnateDB
MMP12 CCL7 18660381 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 CCL7 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
LEF1 CCL7 11118053 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CCL7 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN CCL7 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CCL7 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000001C659 CCL7 25416803 27113293 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CCL7 MMP2 25361965 interaction type N/A PTMCode2
MMP2 CCL7 25361965 interaction type N/A PTMCode2
CCL7 CCR2 25361965 interaction type N/A PTMCode2
CCR2 CCL7 25361965 interaction type N/A PTMCode2
CCL7 CCR1 25361965 interaction type N/A PTMCode2
CCR1 CCL7 25361965 interaction type N/A PTMCode2
CCL7 CCR10 25361965 interaction type N/A PTMCode2
CCR10 CCL7 25361965 interaction type N/A PTMCode2
CCL7 CXCR3 25361965 interaction type N/A PTMCode2
CXCR3 CCL7 25361965 interaction type N/A PTMCode2
CCL7 CCL7 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MMP3 CCL7 25348397 N/A in vitro,in vivo ComPPI
MMP14 CCL7 25348397 N/A in vitro,in vivo ComPPI
XCL2 CCL7 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL7 MMP2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
CCL7 FEZ1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CCL7 TLE5 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CCL7 MMP13 25348397 N/A in vitro,in vivo ComPPI
CCL7 CCR10 25348397 N/A in vivo ComPPI
CCL7 CCR1 25348397 N/A experimental interaction detection,physical interaction,physical interaction,biochemical,in vitro,in vivo ComPPI
CCL7 CCR2 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vitro ComPPI
CCL7 CCR5 25348397 N/A physical interaction,biochemical,in vitro ComPPI
CCL7 ACKR4 25348397 N/A physical interaction,biochemical,in vitro ComPPI
CCL7 ACKR2 25348397 N/A physical interaction,in vivo ComPPI
CCL7 CCR3 25348397 N/A experimental interaction detection,physical interaction,physical interaction ComPPI
CCL7 ELAVL1 25348397 N/A physical interaction ComPPI
CCL7 UBQLN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CCL7 CXCR3 25348397 N/A physical interaction,biochemical ComPPI
CCL7 UBQLN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCL7 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
MMP14 CCL7 10947989 12149192 27898060 N/A N/A OmniPath
MMP2 CCL7 10947989 12149192 27898060 N/A N/A OmniPath
CCL7 CXCR3 27898060 9660793 stimulant N/A OmniPath
CCL7 CCR5 10477718 16298345 24218476 27898060 stimulant N/A OmniPath
CCL7 CCR3 10733106 24218476 27898060 8642344 stimulant N/A OmniPath
CCL7 CCR1 11994538 12381680 14991608 24218476 27898060 7545673 8530354 9336350 stimulant N/A OmniPath
CCL7 CCR2 12554737 24218476 27898060 7759884 8530354 9115216 9195948 9276730 9312096 9336350 9346309 stimulant N/A OmniPath
CCL7 ACKR2 24218476 27898060 9405404 N/A N/A OmniPath
MMP13 CCL7 10947989 12149192 27898060 N/A N/A OmniPath
MMP1 CCL7 10947989 12149192 27898060 N/A N/A OmniPath
MMP3 CCL7 10947989 12149192 27898060 N/A N/A OmniPath

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