GENE：CD19
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CD19 |
| FullNmae | CD19 molecule |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1633 |
| EnsembleID | ENSG00000177455 |
| Uniprot | P15391 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CD19 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CD19 | GO:0001923,GO:0002322,GO:0002322,GO:0005886,GO:0005886,GO:0009897,GO:0009897,GO:0016064,GO:0032991,GO:0043552,GO:0045121,GO:0050851,GO:0050853,GO:0050853,GO:0050855,GO:0050864,GO:0051281,GO:0051281,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CD19 | hsa:930 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| CD19 | hsa:930 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| CD19 | hsa:930 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| CD19 | hsa:930 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| CD19 | hsa:930 | path:hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD19 | VAV2 | 11080163 12165654 26192618 | interaction type | N/A | ACSN |
| CD19 | CD22 | 16408005 23180781 9120258 | physical association | anti tag coimmunoprecipitation,pull down | InnateDB |
| PTPN6 | CD19 | 23180781 9120258 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PIK3CD | CD19 | 10706702 15187135 29145629 7528218 7687428 7687539 7691807 | physical association | inferred by curator | Reactome |
| CD19 | VAV1 | 10706702 15187135 29145629 7528218 7687428 7687539 7691807 | physical association | inferred by curator | Reactome |
| CD19 | PIK3R1 | 10706702 15187135 29145629 7528218 7687428 7687539 7691807 | physical association | inferred by curator | Reactome |
| IFITM1 | CD19 | 24243840 29145629 | physical association | inferred by curator | Reactome |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD19 | ABL1 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CD19 | FYN | 20005715 | interaction type | N/A | PSP,SignaLink |
| CD19 | LYN | 20005715 | interaction type | N/A | PSP |
| CD19 | CD79A | 20005715 | interaction type | N/A | PSP |
| CD19 | PLCG2 | 20005715 | interaction type | N/A | PSP |
| CD19 | CBL | 20005715 | interaction type | N/A | PSP,SignaLink |
| CD19 | MAPK1 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CD19 | CD79B | 20005715 | interaction type | N/A | PSP |
| CD19 | SYK | 20005715 | interaction type | N/A | PSP,SignaLink |
| CD19 | BTK | 20005715 | interaction type | N/A | PSP |
| CD19 | PIK3R3 | 20005715 | interaction type | N/A | PSP |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | CD19 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| EGR1 | CD19 | 18971253 9233624 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| GATA2 | CD19 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | CD19 | 9233624 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| CTCF | CD19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CD19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CD19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| APEX1 | CD19 | 10666449 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PAX5 | CD19 | 10666449 12907641 15163413 20208555 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CD19 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | CD19 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ERG | CD19 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002F5FEE | CD19 | 20371350 21572407 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | CD19 | 20371350 21572407 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | CD19 | 20371350 21572407 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | CD19 | 20371350 21572407 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ARID3A | CD19 | 19214191 24234451 25348397 | colocalization | cosedimentation through density gradient | ComPPI,IntAct |
| CD82 | CD19 | 14525934 24234451 25241761 25348397 9804823 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| CBL | CD19 | 14525934 25348397 9178909 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| VAV1 | CD19 | 14525934 25348397 7528218 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK1 | CD19 | 10706702 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| BTK | CD19 | 10201980 14525934 19214191 24234451 25348397 | association | anti bait coimmunoprecipitation,experimental interaction detection,in vitro | ComPPI,HPRD,IntAct |
| SYK | CD19 | 14525934 25348397 9120258 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| VAV2 | CD19 | 11080163 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| LYN | CD19 | 10933394 14525934 25348397 7568175 7589101 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| PIK3R1 | CD19 | 14525934 24234451 25348397 7528218 7684160 | association | coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| CD81 | CD19 | 1383329 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PLCG2 | CD19 | 25348397 | N/A | in vivo | ComPPI |
| SOS1 | CD19 | 10706702 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CD9 | CD19 | 14525934 23289620 24234451 25348397 9804823 | association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| GRB2 | CD19 | 10706702 14525934 15187135 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PIK3R3 | CD19 | 24234451 25348397 8647200 | physical association | coimmunoprecipitation | ComPPI,IntAct |
| ECT2 | CD19 | 25348397 | N/A | physical interaction | ComPPI |
| FYN | CD19 | 14525934 25348397 7589101 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CD79A | CD19 | 14525934 25348397 9120258 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| IGHM | CD19 | 19214191 24234451 24963139 25348397 | association,physical association | anti bait coimmunoprecipitation,proximity ligation assay | ComPPI,IntAct |
| CD79B | CD19 | 14525934 25348397 9120258 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| IFITM1 | CD19 | 25348397 | N/A | physical interaction | ComPPI |
| IGSF8 | CD19 | 25348397 | N/A | physical interaction | ComPPI |
| CR2 | CD19 | 14525934 1702139 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CD19 | CD22 | 14525934 16408005 25348397 27898060 9120258 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| CD19 | MYZAP | 25348397 | N/A | physical interaction | ComPPI |
| CD19 | POLR2M | 25348397 | N/A | physical interaction | ComPPI |
| CD19 | MINDY3 | 25348397 | N/A | physical interaction | ComPPI |
| CD19 | B3GNT3 | 25348397 | N/A | physical interaction | ComPPI |
| CD19 | IGHD | 24234451 24963139 25348397 | physical association | proximity ligation assay | ComPPI,IntAct |
| ABL1 | CD19 | 11120811 14525934 | N/A | experimental interaction detection | HPRD |
| LYN | CD19 | 10201980 10706702 10933394 16497976 27898060 7568175 7589101 9190913 | stimulant | N/A | OmniPath |
| PAX5 | CD19 | 15676205 27898060 | stimulant | N/A | OmniPath |
| ATM | CD19 | 27898060 9190913 | N/A | N/A | OmniPath |
| CD19 | PTPN6 | 27898060 9120258 | N/A | N/A | OmniPath |
| BTK | CD19 | 10201980 10933394 16497976 27898060 | N/A | N/A | OmniPath |
| ABL1 | CD19 | 11120811 20841568 27898060 | stimulant | N/A | OmniPath |
| MAPK1 | CD19 | 10706702 16497976 27898060 | N/A | N/A | OmniPath |
| C3 | CD19 | 15454921 27898060 | N/A | N/A | OmniPath |