GENE：CD2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CD2 |
| FullNmae | CD2 molecule |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1639 |
| EnsembleID | ENSG00000116824 |
| Uniprot | P06729 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CD2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CD2 | GO:0001766,GO:0005102,GO:0005102,GO:0005515,GO:0005576,GO:0005654,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0006915,GO:0007166,GO:0009897,GO:0009898,GO:0009986,GO:0030101,GO:0030101,GO:0030887,GO:0030971,GO:0032729,GO:0032729,GO:0032757,GO:0032760,GO:0032991,GO:0034113,GO:0038023,GO:0042110,GO:0042267,GO:0042802,GO:0043621,GO:0045580,GO:0098609,GO:0098609 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CD2 | hsa:914 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| CD2 | hsa:914 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD2 | CD58 | 19398758 19494291 26192618 26794910 | association | N/A | ACSN |
| CD48 | CD2 | 10359122 15998796 16081768 19398758 19494291 26192618 26794910 | interaction type | N/A | ACSN |
| CD2 | LCK | 19398758 19494291 26192618 26794910 | interaction type | N/A | ACSN |
| CD2 | CD4 | 19398758 19494291 26192618 26794910 | interaction type | N/A | ACSN |
| CD2 | IL2 | 19398758 19494291 26192618 26794910 | interaction type | N/A | ACSN |
| CD2 | IFNG | 19398758 19494291 26192618 26794910 | interaction type | N/A | ACSN |
| CD2 | LAT | 10359122 15998796 16081768 19398758 19494291 26192618 26794910 | interaction type | N/A | ACSN |
| LGALS1 | CD2 | 10642604 23180781 | physical association | pull down | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | CD2 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CD2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| MYC | CD2 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | CD2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TCFL5 | CD2 | 12923186 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| FOXP3 | CD2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | CD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | CD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | CD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BATF | CD2 | 22592317 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | CD2 | 7929376 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF2 | CD2 | 7929376 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LCK | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | LCK | 25361965 | interaction type | N/A | PTMCode2 |
| PTPRC | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | PTPRC | 25361965 | interaction type | N/A | PTMCode2 |
| CD2AP | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD2AP | 25361965 | interaction type | N/A | PTMCode2 |
| CD4 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD4 | 25361965 | interaction type | N/A | PTMCode2 |
| FYN | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| CD59 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD59 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | SH3KBP1 | 25361965 | interaction type | N/A | PTMCode2 |
| SH3KBP1 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD247 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD247 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD48 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD48 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2BP2 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD2BP2 | 25361965 | interaction type | N/A | PTMCode2 |
| YES1 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | YES1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SH3KBP1 | CD2 | 23663663 24234451 25348397 | N/A | two hybrid,isothermal titration calorimetry,nuclear magnetic resonance,physical interaction,in vitro,in vivo,x ray scattering | ComPPI,IntAct |
| CD2BP2 | CD2 | 10404223 12426371 15105431 16000308 24234451 25348397 27898060 9741631 9843987 | physical association | anti bait coimmunoprecipitation,two hybrid,nuclear magnetic resonance,peptide array,protein array,pull down,physical interaction,in vitro,in vivo | ComPPI,IntAct,OmniPath |
| CD4 | CD2 | 25348397 | N/A | in vitro | ComPPI |
| CD2AP | CD2 | 17020880 23663663 24234451 25348397 9741631 | physical association | anti tag coimmunoprecipitation,two hybrid,isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,x ray scattering,surface plasmon resonance array | ComPPI,IntAct |
| SP1 | CD2 | 25348397 | N/A | in vitro | ComPPI |
| LCK | CD2 | 24234451 25348397 9677430 | phosphorylation reaction | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| CD59 | CD2 | 25348397 | N/A | in vitro | ComPPI |
| CD2 | CD247 | 16049493 25348397 27898060 8977276 | N/A | in vitro,in vivo | ComPPI,OmniPath |
| CD2 | MXD1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| CD2 | PSTPIP1 | 11971877 24234451 25348397 9857189 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| CD2 | CD48 | 12356317 25348397 27898060 | N/A | physical interaction,in vitro,in vivo | ComPPI,OmniPath |
| CD2 | FYN | 24234451 25348397 9677430 | phosphorylation reaction,physical association | anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| CD2 | LGALS1 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| CD2 | PTPRC | 1970422 1976695 25348397 27898060 | N/A | physical interaction,in vitro,in vivo | ComPPI,OmniPath |
| CD2 | CD53 | 1346273 25348397 27898060 | N/A | physical interaction,in vivo | ComPPI,OmniPath |
| CD2 | CD5 | 10510361 25348397 27898060 | N/A | physical interaction,in vivo | ComPPI,OmniPath |
| CD2 | CD58 | 21982860 24234451 25348397 | physical association | protein array,physical interaction,in vitro | ComPPI,IntAct |
| CD2 | ITK | 25348397 | N/A | physical interaction | ComPPI |
| CD2 | UBC | 25348397 | N/A | physical interaction | ComPPI |
| CD2 | EP300 | 21988832 24234451 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| LYAR | CD2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CKS1B | CD2 | 24234451 29997244 | physical association | bioluminescence resonance energy transfer | IntAct |
| DNAJC5 | CD2 | 24234451 29997244 | physical association | bioluminescence resonance energy transfer | IntAct |