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GENE：CD274

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD274
FullNmae CD274 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17635
EnsembleID ENSG00000120217
Uniprot Q9NZQ7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD274 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD274 cuproptosis 38006800 As for CRG, 19 CRGs(CP,CD274,PDE3B,DLAT,VEGFA,DBH,COX11,COA6,PDK1,SLC31A2,UBE2D1,UlK1,SLC25A3,MTF1,UBE2D3,SLC31A1,MAP2K1,AOC3,CCL8) were significantly differentially expressed in the Control and sepsis induced cardiotoxicity groups in GSE44363 cuproptosis-related genes
CD274 cuproptosis 38348451 CD274, also known as PD-L1, is not directly associated with copper metabolism. However, it may play a role in immune regulation, and its involvement in cuproptosis might be related to immune response modulation. CRGs in the cuproptosis pathway
CD274 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
CD274 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CD274 GO:0002250,GO:0002845,GO:0003713,GO:0005515,GO:0005654,GO:0005886,GO:0005886,GO:0006955,GO:0006955,GO:0007165,GO:0007166,GO:0007166,GO:0009897,GO:0015629,GO:0030335,GO:0031295,GO:0031295,GO:0031901,GO:0032689,GO:0032693,GO:0032733,GO:0034097,GO:0042102,GO:0042102,GO:0042130,GO:0046007,GO:0055038,GO:0070062,GO:0071222,GO:1903556,GO:1905404,GO:2000562,GO:2001186

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD274 hsa:29126 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CD274 hsa:29126 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD274 PDCD1 11015443 12893276 18841514 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
PDCD1 CD274 21422170 23180781 physical association x-ray crystallography InnateDB

Source Target Pmid Interactiontype Methods Database
AR CD274 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CD274 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
STAT3 CD274 19088198 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SMARCA4 CD274 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CD274 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD274 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CD274 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000250A40 CD274 22190470 23430453 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000049FAE8 CD274 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002CAE0C CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000019D79B CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000027352D CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000355E82 CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000041FA2C CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000A939F CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000B989F CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000160683 CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272A3D CD274 24577056 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000381CEC CD274 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002F74F1 CD274 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000302909 CD274 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D CD274 25416803 27080341 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000254A6 CD274 25416803 27080341 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000EED18 CD274 25416803 25499621 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000000C73C CD274 25416803 28056089 28427226 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000012A1DD CD274 25416803 28056089 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000058878F CD274 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CD274 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041CB9C CD274 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000040EE1D CD274 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F0F49 CD274 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007D64A CD274 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDCD1 CD274 25361965 interaction type N/A PTMCode2
CD274 PDCD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RINT1 CD274 25348397 N/A physical interaction ComPPI
CDK5RAP3 CD274 25348397 N/A physical interaction ComPPI
COG8 CD274 25348397 N/A physical interaction ComPPI
PTPN11 CD274 25348397 N/A physical interaction ComPPI
ATR CD274 25348397 N/A physical interaction ComPPI
GSK3B CD274 25348397 N/A physical interaction ComPPI
NUP85 CD274 25348397 N/A physical interaction ComPPI
XPO6 CD274 25348397 N/A physical interaction ComPPI
STAG1 CD274 25348397 N/A physical interaction ComPPI
EXOC1 CD274 25348397 N/A physical interaction ComPPI
ATM CD274 25348397 N/A physical interaction ComPPI
TNPO1 CD274 25348397 N/A physical interaction ComPPI
IPO7 CD274 25348397 N/A physical interaction ComPPI
COG5 CD274 25348397 N/A physical interaction ComPPI
XPO4 CD274 25348397 N/A physical interaction ComPPI
CD274 PDCD1 12719480 12893276 14525934 20587542 21982860 23417675 24234451 25348397 physical association experimental interaction detection,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,protein array,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
CD274 CD80 18585785 20587542 21982860 23417675 24234451 25348397 physical association fluorescence-activated cell sorting,protein array,surface plasmon resonance,physical interaction ComPPI,IntAct
CD274 SLC39A11 25348397 N/A physical interaction ComPPI
CD274 THADA 25348397 N/A physical interaction ComPPI
CD274 UTP20 25348397 N/A physical interaction ComPPI
CD274 GCN1 25348397 N/A physical interaction ComPPI
CD274 TMEM160 25348397 N/A physical interaction ComPPI
CD274 TNPO2 25348397 N/A physical interaction ComPPI
CD274 SAAL1 25348397 N/A physical interaction ComPPI
CD274 TTI1 25348397 N/A physical interaction ComPPI
CD274 HEATR1 25348397 N/A physical interaction ComPPI
CD274 COG2 25348397 N/A physical interaction ComPPI
CD274 HIP1R 25348397 N/A physical interaction ComPPI
CD274 USP22 25348397 N/A physical interaction ComPPI
CD274 PI4KA 25348397 N/A physical interaction ComPPI
CD274 EXOC7 25348397 N/A physical interaction ComPPI
CD274 INTS2 25348397 N/A physical interaction ComPPI
CD274 CIP2A 25348397 N/A physical interaction ComPPI
CD274 COG1 25348397 N/A physical interaction ComPPI
CD274 MTOR 25348397 N/A physical interaction ComPPI
CD274 COG3 25348397 N/A physical interaction ComPPI
CD274 TNPO3 25348397 N/A physical interaction ComPPI
CD274 KIF14 25348397 N/A physical interaction ComPPI
CD274 COG4 25348397 N/A physical interaction ComPPI
CD274 VAC14 25348397 N/A physical interaction ComPPI
CD274 NF1 25348397 N/A physical interaction ComPPI
CD274 PDS5B 25348397 N/A physical interaction ComPPI
CD274 SLC7A3 25348397 N/A physical interaction ComPPI
CD274 FAM114A2 25348397 N/A physical interaction ComPPI
CD274 MINPP1 25348397 N/A physical interaction ComPPI
CD274 PDCD1LG2 20587542 24234451 25348397 28813410 association,physical association anti tag coimmunoprecipitation,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CD274 CTLA4 20587542 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CD274 CMTM6 24234451 25348397 28813410 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
CD274 CMTM4 24234451 25348397 28813410 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
XPO7 CD274 25348397 N/A physical interaction ComPPI
COG7 CD274 25348397 N/A physical interaction ComPPI
DOLK CD274 25348397 N/A physical interaction ComPPI
CD274 PDCD1 11015443 12719480 12893276 18841514 21422170 21982860 26602187 27898060 stimulant N/A OmniPath

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