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GENE：CD2AP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD2AP
FullNmae CD2 associated protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14258
EnsembleID ENSG00000198087
Uniprot Q9Y5K6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD2AP mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD2AP immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD2AP disulfidptosis 40214854 CD2AP (CD2-associated protein), a key gene related to Disulfidptosis, is involved in cytoskeleton reorganization and signaling. retulator signature

Go Annotation:

GeneSymbol Go id
CD2AP GO:0001650,GO:0001726,GO:0005200,GO:0005515,GO:0005737,GO:0005886,GO:0005886,GO:0005911,GO:0006930,GO:0007015,GO:0007015,GO:0007049,GO:0007165,GO:0015629,GO:0016477,GO:0017124,GO:0030424,GO:0030425,GO:0031252,GO:0031594,GO:0031941,GO:0031982,GO:0032905,GO:0032911,GO:0032956,GO:0034451,GO:0042802,GO:0045296,GO:0050714,GO:0050808,GO:0051058,GO:0051301,GO:0065003,GO:0070062,GO:1900182

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD2AP hsa:23607 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GZMB CD2AP 17283187 19103589 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
CD2AP PSTPIP1 20005715 interaction type N/A PSP
CD2AP ABL1 20005715 interaction type N/A PSP,SignaLink
CD2AP FYN 20005715 interaction type N/A PSP
CD2AP CD2 20005715 interaction type N/A PSP
CD2AP SRC 20005715 interaction type N/A PSP
CD2AP RAB4A 20005715 interaction type N/A PSP
CD2AP CBL 11067845 12618476 15128873 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
CD2AP CBLB 20005715 interaction type N/A PSP
CD2AP PTK2B 20005715 interaction type N/A PSP,SignaLink
CD2AP SRC 10339567 18988627 20005715 N/A N/A SignaLink
CD2AP FYN 10339567 18988627 20005715 20005715 N/A N/A SignaLink
CD2AP PSTPIP1 12530983 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR CD2AP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CD2AP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CD2AP 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CD2AP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CD2AP 18971253 22880102 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CD2AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
LMX1B CD2AP 11956244 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CD2AP 21604172 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CD2AP 21604172 trascriptional regulation,stimulation inferred by curator TFlink
SP3 CD2AP 21604172 trascriptional regulation,stimulation inferred by curator TFlink
MYC CD2AP N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB CD2AP 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00002152A8 CD2AP 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00005651EE CD2AP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 CD2AP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000013ABA3 CD2AP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 CD2AP 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001919B0 CD2AP 22012620 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000AD02D CD2AP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D CD2AP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB CD2AP 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000427B68 CD2AP 23313552 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001B341F CD2AP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 CD2AP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003FA24D CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6EFA CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 CD2AP 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 CD2AP 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A CD2AP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002FAA8C CD2AP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 CD2AP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB CD2AP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD231 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 CD2AP 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 CD2AP 23313552 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 CD2AP 22927820 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002C02E4 CD2AP 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CBLB CD2AP 25361965 interaction type N/A PTMCode2
CD2AP CBLB 25361965 interaction type N/A PTMCode2
CD2AP RAB4A 25361965 interaction type N/A PTMCode2
RAB4A CD2AP 25361965 interaction type N/A PTMCode2
CD2AP NPHS2 25361965 interaction type N/A PTMCode2
NPHS2 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP FYN 25361965 interaction type N/A PTMCode2
FYN CD2AP 25361965 interaction type N/A PTMCode2
CD2AP CD2 25361965 interaction type N/A PTMCode2
CD2 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP SH3GLB2 25361965 interaction type N/A PTMCode2
SH3GLB2 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP NPHS1 25361965 interaction type N/A PTMCode2
NPHS1 CD2AP 25361965 interaction type N/A PTMCode2
ASAP1 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP ASAP1 25361965 interaction type N/A PTMCode2
CBL CD2AP 25361965 interaction type N/A PTMCode2
CD2AP CBL 25361965 interaction type N/A PTMCode2
WTIP CD2AP 25361965 interaction type N/A PTMCode2
CD2AP WTIP 25361965 interaction type N/A PTMCode2
PKD2 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP PKD2 25361965 interaction type N/A PTMCode2
GRB2 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP GRB2 25361965 interaction type N/A PTMCode2
PIK3R1 CD2AP 25361965 interaction type N/A PTMCode2
CD2AP PIK3R1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I CD2AP 25348397 N/A physical interaction ComPPI
FRS3 CD2AP 25348397 N/A physical interaction ComPPI
YES1 CD2AP 10339567 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RAB4A CD2AP 12559036 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SH3KBP1 CD2AP 17606992 20457601 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IMPDH2 CD2AP 25348397 N/A physical interaction ComPPI
LMNA CD2AP 25348397 N/A physical interaction ComPPI
STAP1 CD2AP 25348397 N/A physical interaction ComPPI
VPS37B CD2AP 17853893 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NF2 CD2AP 25348397 N/A physical interaction ComPPI
CBL CD2AP 11067845 12559036 12618476 12672817 12874286 14525934 15128873 17020880 17072306 17188587 22706086 24234451 25036637 25348397 25872741 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
ZYX CD2AP 25348397 N/A physical interaction ComPPI
CBLB CD2AP 17020880 23663663 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,isothermal titration calorimetry,nuclear magnetic resonance,pull down,x-ray crystallography,physical interaction ComPPI,IntAct
BLNK CD2AP 21822214 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
RACGAP1 CD2AP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NPHS1 CD2AP 10997929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CD2AP PIK3R1 10339567 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD2AP PKD2 10913159 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
CD2AP SOS1 14525934 14679214 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
CD2AP CD2 17020880 23663663 24234451 25348397 9741631 physical association anti tag coimmunoprecipitation,two hybrid,isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,x ray scattering,surface plasmon resonance array ComPPI,IntAct
CD2AP SRC 10339567 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD2AP GRB2 10339567 14525934 19380743 21706016 21988832 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
CD2AP SOS2 14525934 14679214 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
CD2AP CAPZA1 12690097 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD2AP NPHS2 11733557 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD2AP PSTPIP1 12530983 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CD2AP MVB12A 14525934 16895919 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CD2AP PDCD6IP 14525934 17853893 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CD2AP FYN 10339567 14525934 17474147 24234451 25348397 physical association experimental interaction detection,peptide array,in vitro,in vivo ComPPI,HPRD,IntAct
CD2AP HCK 12029088 14525934 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
CD2AP BCAR1 10339567 12618476 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CD2AP NR4A1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CD2AP NR2C2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CD2AP HBP1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CD2AP HOXC11 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CD2AP KHDRBS1 25348397 N/A physical interaction ComPPI
CD2AP ACTC1 25348397 N/A physical interaction ComPPI
CD2AP CTTN 25348397 N/A physical interaction ComPPI
CD2AP EGFR 25348397 N/A physical interaction ComPPI
CD2AP DNM2 25348397 N/A physical interaction ComPPI
CD2AP TSG101 17853893 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD2AP INPP5D 25348397 N/A physical interaction ComPPI
CD2AP CAPZB 25348397 N/A physical interaction ComPPI
CD2AP CBLC 25348397 N/A physical interaction ComPPI
CD2AP CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD2AP SH3BP1 25348397 N/A physical interaction ComPPI
CD2AP NRAS 25348397 N/A physical interaction ComPPI
CD2AP VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
CD2AP ITGA4 25348397 N/A physical interaction ComPPI
CD2AP PTGES3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD2AP UBC 25348397 N/A physical interaction ComPPI
CD2AP GZMB 25348397 N/A physical interaction ComPPI
CD2AP LOX 25348397 N/A physical interaction ComPPI
CD2AP ARHGEF10 25348397 N/A physical interaction ComPPI
CD2AP BRCC3 25348397 N/A physical interaction ComPPI
CD2AP CCDC6 25348397 N/A physical interaction ComPPI
CD2AP ELP2 25348397 N/A physical interaction ComPPI
CD2AP SPAG9 25348397 N/A physical interaction ComPPI
CD2AP HNRNPR 25348397 N/A physical interaction ComPPI
CD2AP HUWE1 25348397 N/A physical interaction ComPPI
CD2AP MTA2 25348397 N/A physical interaction ComPPI
CD2AP NR3C1 25348397 N/A physical interaction ComPPI
CD2AP ELP1 25348397 N/A physical interaction ComPPI
CD2AP WASHC5 25348397 N/A physical interaction ComPPI
CD2AP WASHC4 25348397 N/A physical interaction ComPPI
CD2AP LARP7 25348397 N/A physical interaction ComPPI
CD2AP NOLC1 25348397 N/A physical interaction ComPPI
CD2AP RABEP2 25348397 N/A physical interaction ComPPI
CD2AP TSC22D1 25348397 N/A physical interaction ComPPI
CD2AP USP34 25348397 N/A physical interaction ComPPI
CD2AP WDHD1 25348397 N/A physical interaction ComPPI
CD2AP SLC25A41 25348397 N/A physical interaction ComPPI
CD2AP TAS2R7 25348397 N/A physical interaction ComPPI
CD2AP ASNS 25348397 N/A physical interaction ComPPI
CD2AP DPH5 25348397 N/A physical interaction ComPPI
CD2AP GALE 25348397 N/A physical interaction ComPPI
CD2AP MSN 25348397 N/A physical interaction ComPPI
CD2AP NPLOC4 25348397 N/A physical interaction ComPPI
CD2AP PFDN2 25348397 N/A physical interaction ComPPI
CD2AP PPA2 25348397 N/A physical interaction ComPPI
CD2AP PRDX6 25348397 N/A physical interaction ComPPI
CD2AP SCPEP1 25348397 N/A physical interaction ComPPI
CD2AP SEC24C 25348397 N/A physical interaction ComPPI
CD2AP SEC24D 25348397 N/A physical interaction ComPPI
CD2AP TTC27 25348397 N/A physical interaction ComPPI
CD2AP UFD1 25348397 N/A physical interaction ComPPI
CD2AP NIT1 25348397 N/A physical interaction ComPPI
CD2AP MED4 25348397 N/A physical interaction ComPPI
CD2AP RPGRIP1L 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CD2AP KIF23 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD2AP ATP6AP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD2AP KIF15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD2AP CDH1 25348397 N/A physical interaction ComPPI
CD2AP TCP10L 25348397 N/A physical interaction ComPPI
CD2AP ARHGAP44 25348397 N/A physical interaction ComPPI
CD2AP MRPL12 25348397 N/A physical interaction ComPPI
CD2AP SLC25A10 25348397 N/A physical interaction ComPPI
CD2AP DACH2 25348397 N/A physical interaction ComPPI
CD2AP SETX 25348397 N/A physical interaction ComPPI
CD2AP UBE2A 25348397 N/A physical interaction ComPPI
CD2AP HNRNPL 25348397 N/A physical interaction ComPPI
CD2AP ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CD2AP VPS28 17853893 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CD2AP PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
IQGAP1 CD2AP 22662192 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy,proximity ligation assay ComPPI,IntAct
SH3GL2 CD2AP 25348397 N/A physical interaction ComPPI
CSTF2 CD2AP 25348397 N/A physical interaction ComPPI
NRBP1 CD2AP 25348397 N/A physical interaction ComPPI
ARHGAP17 CD2AP 25348397 N/A physical interaction ComPPI
CD2AP CD2AP 10339567 14525934 17020880 24234451 association anti tag coimmunoprecipitation,experimental interaction detection,two hybrid HPRD,IntAct
WTIP CD2AP 14525934 14736876 N/A experimental interaction detection HPRD
STK38L CD2AP 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
CREB1 CD2AP 18396147 27898060 stimulant N/A OmniPath
SP1 CD2AP 18396147 27898060 stimulant N/A OmniPath

Visualization










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