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GENE：CD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD4
FullNmae CD4 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1678
EnsembleID ENSG00000010610
Uniprot P01730

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD4 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature retulator signature

Go Annotation:

GeneSymbol Go id
CD4 GO:0001618,GO:0001934,GO:0002250,GO:0004888,GO:0005201,GO:0005515,GO:0005769,GO:0005788,GO:0005789,GO:0005886,GO:0005886,GO:0006955,GO:0007155,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0008270,GO:0008289,GO:0009897,GO:0009897,GO:0015026,GO:0019722,GO:0019899,GO:0019901,GO:0023026,GO:0030217,GO:0030225,GO:0030669,GO:0032507,GO:0032743,GO:0033674,GO:0035397,GO:0035723,GO:0035723,GO:0038023,GO:0042011,GO:0042012,GO:0042101,GO:0042110,GO:0042289,GO:0042289,GO:0042289,GO:0042289,GO:0042802,GO:0042803,GO:0043123,GO:0043410,GO:0045058,GO:0045121,GO:0045121,GO:0045657,GO:0045860,GO:0045893,GO:0046598,GO:0046718,GO:0050731,GO:0050829,GO:0050850,GO:0050863,GO:0050870,GO:0051924,GO:0070374,GO:0070374,GO:0097011,GO:1990782,GO:1990782

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD4 hsa:920 path:hsa03250 Viral life cycle - HIV-1 - Homo sapiens (human)
CD4 hsa:920 path:hsa03260 Virion - Human immunodeficiency virus - Homo sapiens (human)
CD4 hsa:920 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CD4 hsa:920 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CD4 hsa:920 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
CD4 hsa:920 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
CD4 hsa:920 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
CD4 hsa:920 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
CD4 hsa:920 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CD4 hsa:920 path:hsa05135 Yersinia infection - Homo sapiens (human)
CD4 hsa:920 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CD4 hsa:920 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
CD4 hsa:920 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
CD4 hsa:920 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LCK CD4 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 association N/A ACSN
SH2D2A CD4 10975797 26192618 27896837 interaction type N/A ACSN
LAG3 CD4 15586367 22437870 26192618 27192565 7589152 interaction type N/A ACSN
BAG6 CD4 16286920 18055229 20819927 22437870 22863785 23414611 26192618 27192565 28900677 interaction type N/A ACSN
HAVCR2 CD4 16286920 18055229 20819927 22437870 22863785 23414611 26192618 27192565 28900677 interaction type N/A ACSN
CD2 CD4 19398758 19494291 26192618 26794910 interaction type N/A ACSN
CD58 CD4 19398758 19494291 26192618 26794910 interaction type N/A ACSN
CD4 VAV1 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 ITK 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 CD247 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 PTPRC 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 ZAP70 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 PRKCQ 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 CRTAM 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 SCRIB 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 IL16 23180781 7910967 physical association anti tag coimmunoprecipitation InnateDB
LGALS1 CD4 10490978 23180781 physical association pull down InnateDB
CD4 CXCR4 19066282 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIP CD4 10820003 23180781 physical association solid phase assay InnateDB
CD4 LCK 15489916 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CD53 CD4 20005715 interaction type N/A PSP
CD81 CD4 20005715 interaction type N/A PSP
LAT CD4 20005715 interaction type N/A PSP
PIK3R1 CD4 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 CD4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CD4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 CD4 9765424 trascriptional regulation,stimulation inferred by curator TFlink
EIF2AK2 CD4 8995707 trascriptional regulation,stimulation inferred by curator TFlink
GATD3B CD4 11287612 trascriptional regulation,stimulation inferred by curator TFlink
HES1 CD4 11287612 trascriptional regulation,stimulation inferred by curator TFlink
MAZ CD4 7760814 trascriptional regulation,stimulation inferred by curator TFlink
MYB CD4 11287612 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L1 CD4 17486074 trascriptional regulation,stimulation inferred by curator TFlink
TCF3 CD4 17486074 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 CD4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002AAD6B CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001310DE CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000081D1E CD4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F CD4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 CD4 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA CD4 22135298 phosphorylation N/A PhosphoSite
CD4 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF10A CD4 25361965 interaction type N/A PTMCode2
CD4 CD38 25361965 interaction type N/A PTMCode2
CD38 CD4 25361965 interaction type N/A PTMCode2
CD4 CD81 25361965 interaction type N/A PTMCode2
CD81 CD4 25361965 interaction type N/A PTMCode2
CD4 ZAP70 25361965 interaction type N/A PTMCode2
ZAP70 CD4 25361965 interaction type N/A PTMCode2
CD4 PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R1 CD4 25361965 interaction type N/A PTMCode2
CD4 CD44 25361965 interaction type N/A PTMCode2
CD44 CD4 25361965 interaction type N/A PTMCode2
CD4 PIP 25361965 interaction type N/A PTMCode2
PIP CD4 25361965 interaction type N/A PTMCode2
CD4 CD28 25361965 interaction type N/A PTMCode2
CD28 CD4 25361965 interaction type N/A PTMCode2
CD4 LCK 25361965 interaction type N/A PTMCode2
LCK CD4 25361965 interaction type N/A PTMCode2
CD4 CD5 25361965 interaction type N/A PTMCode2
CD5 CD4 25361965 interaction type N/A PTMCode2
CD4 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CD4 25361965 interaction type N/A PTMCode2
CD4 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD4 25361965 interaction type N/A PTMCode2
CD4 CD2 25361965 interaction type N/A PTMCode2
CD2 CD4 25361965 interaction type N/A PTMCode2
CD4 BTRC 25361965 interaction type N/A PTMCode2
BTRC CD4 25361965 interaction type N/A PTMCode2
CD4 SYK 25361965 interaction type N/A PTMCode2
SYK CD4 25361965 interaction type N/A PTMCode2
CD4 CXCR4 25361965 interaction type N/A PTMCode2
CXCR4 CD4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TMEM11 CD4 25348397 N/A physical interaction ComPPI
HSPA8 CD4 25348397 N/A physical interaction ComPPI
LAT CD4 10562325 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TFRC CD4 14525934 14705953 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ANXA1 CD4 25348397 N/A physical interaction ComPPI
NPM1 CD4 25348397 N/A physical interaction ComPPI
VIM CD4 25348397 N/A physical interaction ComPPI
TUBB CD4 25348397 N/A physical interaction ComPPI
VCP CD4 25348397 N/A physical interaction ComPPI
ACTB CD4 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
HSP90AB1 CD4 25348397 N/A physical interaction ComPPI
UBL7 CD4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD44 CD4 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD82 CD4 14525934 25348397 7636191 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CD4 CD38 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 PIK3R1 14525934 25348397 8246987 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 CD28 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 CD2 25348397 N/A in vitro ComPPI
CD4 DPP4 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 CXCL12 10600606 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CD4 CCR5 10816381 14525934 15660419 24234451 25348397 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CD4 IL16 1851800 25348397 27898060 7910967 N/A experimental interaction detection,physical interaction,in vivo ComPPI,OmniPath
CD4 UNC119 14525934 14757743 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD4 SELL 25348397 N/A in vitro ComPPI
CD4 PIP 10820003 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CD4 HLA-DQA2 11535811 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 SPG21 11113139 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
CD4 CTSD 11581410 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CD4 TNFRSF10A 14525934 25348397 27898060 7650480 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CD4 HLA-DQB1 11535811 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 KCNAB2 12893943 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CD4 HLA-DPA1 12899833 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CD4 FCGR3A 11756173 25348397 27898060 N/A in vitro ComPPI,OmniPath
CD4 IL2RA 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 LGALS1 10490978 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD4 PTPRC 25348397 N/A physical interaction,in vivo ComPPI
CD4 CD53 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 CD5 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD4 LCK 11854499 14525934 16888650 17005671 24234451 25348397 8104794 8246987 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CD4 CXCR4 10816381 14525934 15660419 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CD4 CD81 25348397 N/A physical interaction ComPPI
CD4 SYK 25348397 N/A physical interaction ComPPI
CD4 ZAP70 25348397 N/A physical interaction ComPPI
CD4 EPS15 25348397 N/A physical interaction ComPPI
CD4 MAPK14 25348397 N/A physical interaction ComPPI
CD4 LRPPRC 25348397 N/A physical interaction ComPPI
CD4 EIF3C 25348397 N/A physical interaction ComPPI
CD4 TNPO1 25348397 N/A physical interaction ComPPI
CD4 KPNB1 25348397 N/A physical interaction ComPPI
CD4 EIF3B 25348397 N/A physical interaction ComPPI
CD4 HSP90AA1 25348397 N/A physical interaction ComPPI
CD4 HSP90AA2P 25348397 N/A physical interaction ComPPI
CD4 MME 25348397 N/A physical interaction ComPPI
CD4 SSRP1 25348397 N/A physical interaction ComPPI
CD4 ANXA6 25348397 N/A physical interaction ComPPI
CD4 NCL 25348397 N/A physical interaction ComPPI
CD4 DDX3X 25348397 N/A physical interaction ComPPI
CD4 DDX5 25348397 N/A physical interaction ComPPI
CD4 FARSB 25348397 N/A physical interaction ComPPI
CD4 EIF3D 25348397 N/A physical interaction ComPPI
CD4 HSPD1 25348397 N/A physical interaction ComPPI
CD4 ATP5F1A 25348397 N/A physical interaction ComPPI
CD4 HNRNPH1 25348397 N/A physical interaction ComPPI
CD4 ENO1 25348397 N/A physical interaction ComPPI
CD4 EIF4A2 25348397 N/A physical interaction ComPPI
CD4 GNAI2 25348397 N/A physical interaction ComPPI
CD4 HNRNPA1 25348397 N/A physical interaction ComPPI
CD4 ANXA2P2 25348397 N/A physical interaction ComPPI
CD4 ANXA2 25348397 N/A physical interaction ComPPI
CD4 HNRNPD 25348397 N/A physical interaction ComPPI
CD4 VDAC2 25348397 N/A physical interaction ComPPI
CD4 HNRNPA2B1 25348397 N/A physical interaction ComPPI
CD4 EIF3I 25348397 N/A physical interaction ComPPI
CD4 GAPDH 25348397 N/A physical interaction ComPPI
CD4 RPLP0 25348397 N/A physical interaction ComPPI
CD4 RPLP0P6 25348397 N/A physical interaction ComPPI
CD4 RPSA 25348397 N/A physical interaction ComPPI
CD4 VDAC1 25348397 N/A physical interaction ComPPI
CD4 VDAC3 25348397 N/A physical interaction ComPPI
CD4 PHB 25348397 N/A physical interaction ComPPI
CD4 RPL7 25348397 N/A physical interaction ComPPI
CD4 DHRS2 25348397 N/A physical interaction ComPPI
CD4 RPS9 25348397 N/A physical interaction ComPPI
CD4 RPL18 25348397 N/A physical interaction ComPPI
CD4 MYL12B 25348397 N/A physical interaction ComPPI
CD4 MYL12A 25348397 N/A physical interaction ComPPI
CD4 RPS10 25348397 N/A physical interaction ComPPI
CD4 RPS19 25348397 N/A physical interaction ComPPI
CD4 RPL22 25348397 N/A physical interaction ComPPI
CD4 RPS12 25348397 N/A physical interaction ComPPI
CD4 RPLP1 25348397 N/A physical interaction ComPPI
CD4 STUB1 25348397 N/A physical interaction ComPPI
CD4 NR3C1 16888650 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD4 HGS 25348397 N/A physical interaction ComPPI
CD4 INPPL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD4 ABCB1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD4 ADRB2 25348397 N/A physical interaction ComPPI
CD4 RANBP9 25348397 N/A physical interaction ComPPI
CD4 SIVA1 25348397 N/A physical interaction ComPPI
CD4 KIAA0319L 25348397 N/A physical interaction ComPPI
CD4 POGZ 25348397 N/A physical interaction ComPPI
CD4 ATP6V0A2 25348397 N/A physical interaction ComPPI
CD4 CCDC85C 25348397 N/A physical interaction ComPPI
CD4 ARV1 25348397 N/A physical interaction ComPPI
CD4 ATP6V0A1 25348397 N/A physical interaction ComPPI
CD4 EIF2B3 25348397 N/A physical interaction ComPPI
CD4 SAAL1 25348397 N/A physical interaction ComPPI
CD4 CD320 25348397 N/A physical interaction ComPPI
CD4 EIF2B4 25348397 N/A physical interaction ComPPI
VAMP3 CD4 25348397 N/A physical interaction ComPPI
EEF1B2 CD4 25348397 N/A physical interaction ComPPI
MARCHF4 CD4 14525934 14722266 N/A experimental interaction detection HPRD
CD4 CD4 12444132 14525934 24234451 9168119 N/A protein cross-linking with a bifunctional reagent,experimental interaction detection,x-ray crystallography HPRD,IntAct
KRT18 CD4 24234451 30021884 physical association cross-linking study IntAct
KRT8 CD4 24234451 30021884 physical association cross-linking study IntAct
UBA52 CD4 24234451 30021884 physical association cross-linking study IntAct
PRKCA CD4 15494497 1674746 27898060 N/A N/A OmniPath
CXCR4 CD4 10816381 14592831 15660419 19066282 27898060 N/A N/A OmniPath
AURKB CD4 1674746 27898060 N/A N/A OmniPath
RUNX3 CD4 17641686 27898060 stimulant N/A OmniPath
RUNX1 CD4 17641686 27898060 stimulant N/A OmniPath
UFD1 CD4 20442859 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B21E7 CD4 27087310 direct interaction,inhibition N/A NPInter

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