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GENE：CD40

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD40
FullNmae CD40 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11919
EnsembleID ENSG00000101017
Uniprot P25942

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD40 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD40 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CD40 GO:0001934,GO:0002768,GO:0003823,GO:0005515,GO:0005886,GO:0005886,GO:0006874,GO:0006954,GO:0009897,GO:0009986,GO:0019724,GO:0019899,GO:0019904,GO:0023035,GO:0023035,GO:0030168,GO:0030890,GO:0031625,GO:0032735,GO:0033590,GO:0034341,GO:0035631,GO:0035631,GO:0035666,GO:0036018,GO:0038023,GO:0042100,GO:0042113,GO:0042531,GO:0042531,GO:0042832,GO:0043025,GO:0043123,GO:0043123,GO:0043196,GO:0043231,GO:0043406,GO:0043491,GO:0043536,GO:0043536,GO:0043547,GO:0045766,GO:0045766,GO:0045944,GO:0045944,GO:0048304,GO:0051092,GO:0051092,GO:0051607,GO:0065003,GO:0070062,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0090037,GO:1901652,GO:2000353,GO:2000353

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD40 hsa:958 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CD40 hsa:958 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
CD40 hsa:958 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CD40 hsa:958 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
CD40 hsa:958 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
CD40 hsa:958 path:hsa05144 Malaria - Homo sapiens (human)
CD40 hsa:958 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
CD40 hsa:958 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CD40 hsa:958 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CD40 hsa:958 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
CD40 hsa:958 path:hsa05310 Asthma - Homo sapiens (human)
CD40 hsa:958 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
CD40 hsa:958 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
CD40 hsa:958 path:hsa05330 Allograft rejection - Homo sapiens (human)
CD40 hsa:958 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)
CD40 hsa:958 path:hsa05416 Viral myocarditis - Homo sapiens (human)
CD40 hsa:958 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD40LG CD40 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 association N/A ACSN
IL3 CD40 15034038 15549123 17200410 23026134 23125331 23762788 24778133 26192618 interaction type N/A ACSN
STAT1 CD40 10485906 10754326 10820262 10823830 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15182726 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23180781 23390297 25960930 26192618 6357187 7594497 8683106 8871614 interaction type,physical association electrophoretic mobility supershift assay ACSN,InnateDB
CD40 CD80 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 interaction type N/A ACSN
CD40 CD86 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 interaction type N/A ACSN
CD40 CD70 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 interaction type N/A ACSN
TRAF6 CD40 10748240 12637493 16260598 17332487 20676093 23180781 9718306 9990007 physical association anti tag coimmunoprecipitation,gst pull down,pull down InnateDB
TAB2 CD40 12150997 23180781 physical association gst pull down InnateDB
CD40 NCOR1 12150997 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD40 TAB2 12150997 23180781 physical association anti tag coimmunoprecipitation InnateDB
CAV1 CD40 14665433 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD40 TRAF2 10318845 12637493 16282325 17332487 20676093 23180781 8855313 9133417 9168896 9718306 physical association affinity chromatography technology,anti tag coimmunoprecipitation,gst pull down,pull down InnateDB
CBL CD40 12637493 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3 CD40 10318845 12637493 17332487 23180781 9133417 9168896 9718306 physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down InnateDB
IL4R CD40 12207328 23180781 physical association anti tag coimmunoprecipitation InnateDB
REL CD40 17567982 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFSF13B CD40 16644731 17567982 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CD40 CD40LG 17567982 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 CD40 17567982 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD40 TRAF1 10318845 17332487 23180781 9718306 physical association anti tag coimmunoprecipitation,pull down InnateDB
CD40 TRAF5 17332487 20676093 23180781 9718306 physical association anti tag coimmunoprecipitation,pull down InnateDB
CD40 TRAF3 23180781 9718306 physical association pull down InnateDB
KPNA1 CD40 16644731 23180781 physical association anti tag coimmunoprecipitation InnateDB
KPNB1 CD40 16644731 23180781 physical association anti tag coimmunoprecipitation InnateDB
HSPA4 CD40 12356871 23180781 physical association pull down InnateDB
HSPA8 CD40 12356871 23180781 physical association pull down InnateDB
JAK3 CD40 23180781 9133417 physical association anti tag coimmunoprecipitation,pull down InnateDB
CD40 AKNA 11268217 23180781 physical association electrophoretic mobility supershift assay InnateDB
TRAF3IP2 CD40 15485634 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD40 CD40 18635759 26467481 bind,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
YBX1 CD40 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 CD40 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CD40 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CD40 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD40 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CD40 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD40 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CD40 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 CD40 18694960 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CD40 11027342 11313274 17031478 19164127 9733827 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA CD40 9733827 trascriptional regulation,stimulation inferred by curator TFlink
NR3C2 CD40 16179010 trascriptional regulation,stimulation inferred by curator TFlink
RELA CD40 11313274 17031478 19164127 9733827 trascriptional regulation,stimulation inferred by curator TFlink
RELB CD40 11027342 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CD40 10823830 trascriptional regulation,stimulation inferred by curator TFlink
SPIB CD40 10823830 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 CD40 10823830 15182726 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 CD40 11086058 trascriptional regulation,stimulation inferred by curator TFlink
TRAF6 CD40 16143987 trascriptional regulation,stimulation inferred by curator TFlink
TRERF1 CD40 18652845 trascriptional regulation,stimulation inferred by curator TFlink
XRCC5 CD40 17031478 trascriptional regulation,stimulation inferred by curator TFlink
XRCC6 CD40 17031478 trascriptional regulation,stimulation inferred by curator TFlink
AR CD40 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG CD40 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 CD40 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A CD40 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B CD40 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000184017 CD40 19475450 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00000F6E49 CD40 22429276 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000EED18 CD40 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00004F4657 CD40 25416803 27731400 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
RIPK2 CD40 25361965 interaction type N/A PTMCode2
CD40 RIPK2 25361965 interaction type N/A PTMCode2
CD40 JAK3 25361965 interaction type N/A PTMCode2
JAK3 CD40 25361965 interaction type N/A PTMCode2
IL4R CD40 25361965 interaction type N/A PTMCode2
CD40 IL4R 25361965 interaction type N/A PTMCode2
MS4A1 CD40 25361965 interaction type N/A PTMCode2
CD40 MS4A1 25361965 interaction type N/A PTMCode2
TRAF5 CD40 25361965 interaction type N/A PTMCode2
CD40 TRAF5 25361965 interaction type N/A PTMCode2
CBL CD40 25361965 interaction type N/A PTMCode2
CD40 CBL 25361965 interaction type N/A PTMCode2
CD40LG CD40 25361965 interaction type N/A PTMCode2
CD40 CD40LG 25361965 interaction type N/A PTMCode2
MAP3K8 CD40 25361965 interaction type N/A PTMCode2
CD40 MAP3K8 25361965 interaction type N/A PTMCode2
TRAF6 CD40 25361965 interaction type N/A PTMCode2
CD40 TRAF6 25361965 interaction type N/A PTMCode2
PIK3R1 CD40 25361965 interaction type N/A PTMCode2
CD40 PIK3R1 25361965 interaction type N/A PTMCode2
BIRC2 CD40 25361965 interaction type N/A PTMCode2
CD40 BIRC2 25361965 interaction type N/A PTMCode2
BIRC3 CD40 25361965 interaction type N/A PTMCode2
CD40 BIRC3 25361965 interaction type N/A PTMCode2
TRAF3 CD40 25361965 interaction type N/A PTMCode2
CD40 TRAF3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 CD40 12356871 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BAG3 CD40 25348397 N/A physical interaction ComPPI
TRAF6 CD40 10075662 10411888 12140561 14525934 16260598 20676093 24234451 25348397 association experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SLC7A1 CD40 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
INSIG2 CD40 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBL CD40 12637493 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3R1 CD40 12637493 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3CA CD40 25348397 N/A physical interaction ComPPI
FAF1 CD40 25348397 N/A physical interaction ComPPI
CAV1 CD40 14525934 14665433 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NCOA6 CD40 25348397 N/A physical interaction ComPPI
XRCC5 CD40 10514012 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CALR CD40 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IKBKB CD40 25348397 N/A physical interaction ComPPI
TRAF3 CD40 10984535 14525934 16260598 24234451 25348397 7527023 7530216 7533327 physical association two hybrid,experimental interaction detection,pull down,physical interaction,biochemical,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
XRCC6 CD40 10514012 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TXN CD40 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NSMAF CD40 10601289 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PSMD1 CD40 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRAF1 CD40 10411888 14525934 25348397 7527023 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF2 CD40 10411888 14525934 16260598 17353931 20676093 24234451 25348397 25416956 25910212 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,biochemical,in vitro,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
TRAF5 CD40 14525934 20676093 24234451 25348397 8790348 9990007 association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
JAK3 CD40 10395671 14525934 25348397 9133417 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPA4 CD40 12356871 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
OGT CD40 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MYCBP CD40 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CHUK CD40 25348397 N/A physical interaction ComPPI
RIPK2 CD40 14525934 25348397 9642260 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TDP2 CD40 10764746 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAP3K8 CD40 14525934 15670770 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF4 CD40 25348397 N/A physical interaction ComPPI
DIABLO CD40 25348397 N/A physical interaction ComPPI
HTRA2 CD40 25348397 N/A physical interaction ComPPI
DDX3X CD40 25348397 N/A physical interaction ComPPI
CD40LG CD40 10647992 14525934 25348397 7516405 7543281 N/A affinity chromatography technology,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MS4A1 CD40 14525934 25348397 27898060 9933087 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
CD40 IL4R 12207328 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD40 BIRC2 11562359 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD40 BIRC3 11562359 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD40 UGGT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 SGK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 USP15 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 RFC5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 ERP44 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 POLR2H 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 SLC30A7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 SLC39A7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 FBL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40 RNF31 25348397 N/A physical interaction ComPPI
CD40 STING1 25348397 N/A physical interaction ComPPI
CD40 PCMT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CD40 KATNA1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CD40 SLC30A3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 MFSD5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 CMTM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 SLC30A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 TLCD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 TMEM147 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 SLC39A13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 MIP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD40 TMEM107 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF3IP2 CD40 25348397 N/A physical interaction,in vivo ComPPI
TANK CD40 25348397 N/A physical interaction ComPPI
OBI1 CD40 25348397 N/A physical interaction ComPPI
DEFB121 CD40 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPA8 CD40 12356871 27898060 N/A N/A OmniPath
CD40 CAV1 14665433 27898060 N/A N/A OmniPath
CD40 TRAF2 10318845 10352240 10411888 10428814 10518213 10748240 11562359 12220533 12637493 15485859 16260598 16282325 16713569 17332487 17353931 18635759 19667091 20449947 20614026 20676093 21041727 21071692 21282461 25072696 25416956 27898060 8855313 9020361 9133417 9168896 9718306 9990007 stimulant N/A OmniPath
TRAF2 CD40 10318845 10352240 10411888 10428814 10518213 10748240 11562359 12220533 12637493 15485859 16260598 16282325 16713569 17332487 17353931 18635759 19667091 20449947 20614026 20676093 21041727 21071692 21282461 25072696 25416956 27898060 8855313 9020361 9133417 9168896 9718306 9990007 N/A N/A OmniPath
JAK3 CD40 10395671 27898060 9133417 N/A N/A OmniPath
CD40 TRAF6 10075662 10318845 10411888 10748240 12140561 12220533 12637493 15485859 16189514 16260598 17332487 18635759 20449947 20614026 20676093 21041727 24812060 27898060 9384571 9718306 9990007 N/A N/A OmniPath
TRAF6 CD40 10075662 10318845 10411888 10748240 12140561 12220533 12637493 15485859 16189514 16260598 17332487 18635759 20449947 20614026 20676093 21041727 24812060 27898060 9384571 9718306 9990007 N/A N/A OmniPath
REL CD40 17567982 27898060 N/A N/A OmniPath
CD40 CBL 12637493 27898060 N/A N/A OmniPath
CSNK2A1 CD40 1696597 27898060 N/A N/A OmniPath
IL4R CD40 12207328 27898060 N/A N/A OmniPath
CD40 TRAF3 10318845 10352240 10984535 11562359 12220533 12637493 14517219 15485859 16260598 17145710 17332487 17878343 18635759 19667091 20614026 21041727 24260396 24810049 25072696 27898060 7527023 7530216 7533327 7859281 9133417 9168896 9384571 9718306 9990007 inhibition,stimulant N/A OmniPath
CD40 CD40LG 10647992 1280226 23602662 27898060 7516405 7543281 N/A N/A OmniPath
CD40LG CD40 10647992 12324477 1280226 17183360 17567982 19426221 23602662 27898060 7516405 7543281 stimulant N/A OmniPath
CD40 TRAF1 10318845 10411888 17332487 20614026 27898060 7527023 9718306 N/A N/A OmniPath
CD40 HSPA4 12356871 27898060 N/A N/A OmniPath
KPNB1 CD40 16644731 27898060 N/A N/A OmniPath
CD40 TRAF5 11562359 12220533 17332487 20614026 20676093 21041727 27898060 8790348 9511754 9718306 9990007 N/A N/A OmniPath
TRAF3IP2 CD40 12089335 15485634 24120361 27898060 N/A N/A OmniPath
KPNA1 CD40 16644731 27898060 N/A N/A OmniPath
C4BPA CD40 12818164 27898060 N/A N/A OmniPath

Visualization










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