GENE：CD40LG
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CD40LG |
| FullNmae | CD40 ligand |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11935 |
| EnsembleID | ENSG00000102245 |
| Uniprot | P29965 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CD40LG | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CD40LG | GO:0002637,GO:0005125,GO:0005164,GO:0005174,GO:0005174,GO:0005174,GO:0005178,GO:0005515,GO:0005615,GO:0005794,GO:0005886,GO:0005886,GO:0006954,GO:0007159,GO:0007229,GO:0009897,GO:0009986,GO:0016020,GO:0023035,GO:0030168,GO:0030183,GO:0031295,GO:0032733,GO:0032735,GO:0032753,GO:0042100,GO:0042102,GO:0043066,GO:0043539,GO:0045190,GO:0051092,GO:2000353 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CD40LG | hsa:959 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05144 | Malaria - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05310 | Asthma - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05330 | Allograft rejection - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
| CD40LG | hsa:959 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD40LG | CD40 | 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 | association | N/A | ACSN |
| ADORA2A | CD40LG | 17371980 17909080 18758473 26192618 | interaction type | N/A | ACSN |
| ICOS | CD40LG | 10426994 11907067 15536084 16713974 20116985 21708958 26192618 | interaction type | N/A | ACSN |
| CD40LG | CD80 | 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 | interaction type | N/A | ACSN |
| CD40LG | CD86 | 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 | interaction type | N/A | ACSN |
| CD40LG | CD70 | 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 26192618 7523569 8760829 9359474 | interaction type | N/A | ACSN |
| CD40LG | IL2 | 11581322 15034038 17200410 17371980 23125331 26192618 8760829 | interaction type | N/A | ACSN |
| CD40 | CD40LG | 17567982 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| REL | CD40LG | 16099873 17567982 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTBP1 | CD40LG | 12509450 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| ITGA5 | CD40LG | 17182621 23180781 | physical association | solid phase assay | InnateDB |
| AKNA | CD40LG | 11268217 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| NFATC1 | CD40LG | 16099873 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EGR1 | CD40LG | 16393964 19032775 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| NFATC2 | CD40LG | 16393964 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| EGR3 | CD40LG | 16393964 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CD40LG | CD40LG | 12324477 19426221 26467481 | bind,up-regulates activity | N/A | Signor |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CD40LG | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOS | CD40LG | 11160303 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| GATA3 | CD40LG | 18719603 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| JUND | CD40LG | 11160303 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| NFATC2 | CD40LG | 18719603 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| NFKB1 | CD40LG | 11160303 11529914 11751888 21243522 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| REL | CD40LG | 11160303 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| RELA | CD40LG | 11160303 11529914 21243522 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| FOXP3 | CD40LG | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| NFAM1 | CD40LG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | CD40LG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CD40LG | 11425859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | CD40LG | 12855573 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | CD40LG | 12663664 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF2 | CD40LG | 12663664 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB2 | CD40LG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001EFBE3 | CD40LG | 21236257 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00001EFBE3 | CD40LG | 21236257 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000BD6DC | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009EA8F | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E02F2 | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000060AABB | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | CD40LG | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | CD40LG | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | CD40LG | 25416803 28097098 | mrna cleavage,inhibition | array technology | TarBase |
| URS000005D4F5 | CD40LG | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | CD40LG | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CRYAB | CD40LG | 25348397 | N/A | physical interaction | ComPPI |
| IGHG1 | CD40LG | 25348397 | N/A | in vitro | ComPPI |
| APOA1 | CD40LG | 25348397 | N/A | physical interaction | ComPPI |
| TRAF1 | CD40LG | 25348397 | N/A | physical interaction | ComPPI |
| TRAF2 | CD40LG | 25348397 | N/A | physical interaction | ComPPI |
| CD5L | CD40LG | 11981870 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| CD40LG | CD40 | 10647992 14525934 25348397 7516405 7543281 | N/A | affinity chromatography technology,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CD40LG | RNF128 | 14525934 18641297 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| CD40LG | IGKC | 25348397 | N/A | in vitro | ComPPI |
| CD40LG | HP | 25348397 | N/A | physical interaction | ComPPI |
| CD40LG | BIRC2 | 25348397 | N/A | physical interaction | ComPPI |
| CD40LG | BIRC3 | 25348397 | N/A | physical interaction | ComPPI |
| CD40LG | CD40LG | 11525169 14525934 | N/A | experimental interaction detection | HPRD |
| TP53 | CD40LG | 12011072 14525934 | N/A | experimental interaction detection | HPRD |
| ITGA5 | CD40LG | 17182621 27898060 | N/A | N/A | OmniPath |
| CD40 | CD40LG | 10647992 1280226 23602662 27898060 7516405 7543281 | N/A | N/A | OmniPath |
| CD40LG | CD40 | 10647992 12324477 1280226 17183360 17567982 19426221 23602662 27898060 7516405 7543281 | stimulant | N/A | OmniPath |