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GENE：CD46

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD46
FullNmae CD46 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6953
EnsembleID ENSG00000117335
Uniprot P15529

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD46 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CD46 GO:0001618,GO:0002079,GO:0002250,GO:0002456,GO:0002456,GO:0005515,GO:0005615,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006958,GO:0007338,GO:0008593,GO:0009986,GO:0010628,GO:0010629,GO:0032733,GO:0035581,GO:0038023,GO:0042102,GO:0043382,GO:0045087,GO:0045296,GO:0045591,GO:0045959,GO:0046718,GO:0070062,GO:0071636

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD46 hsa:4179 path:hsa03267 Virion - Adenovirus - Homo sapiens (human)
CD46 hsa:4179 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
CD46 hsa:4179 path:hsa05162 Measles - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT3 CD46 17699108 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
GOPC CD46 19837375 23180781 physical association two hybrid,pull down InnateDB
C3 CD46 10960475 11971006 2141838 23180781 8666815 protein cleavage,physical association pull down,protease assay,solid phase assay InnateDB
CD9 CD46 11858824 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN6 CD46 11858824 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD46 C4B 23180781 8666815 physical association solid phase assay InnateDB
CFI CD46 1386357 23180781 protein cleavage protease assay InnateDB
STK39 CD46 20694009 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CD46 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CD46 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CD46 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CD46 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CD46 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CD46 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD46 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CD46 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD46 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 CD46 17699108 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004505E4 CD46 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000039A25B CD46 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000237AF9 CD46 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000007FBA CD46 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000CF1D2 CD46 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000021D7C8 CD46 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000122ED0 CD46 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 CD46 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000013DD8 CD46 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FD1A CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 CD46 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 CD46 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 CD46 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 CD46 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC CD46 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF CD46 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 CD46 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
C3 CD46 25361965 interaction type N/A PTMCode2
CD46 C3 25361965 interaction type N/A PTMCode2
CD46 YES1 25361965 interaction type N/A PTMCode2
YES1 CD46 25361965 interaction type N/A PTMCode2
CD46 MSN 25361965 interaction type N/A PTMCode2
MSN CD46 25361965 interaction type N/A PTMCode2
CD46 ITGB1 25361965 interaction type N/A PTMCode2
ITGB1 CD46 25361965 interaction type N/A PTMCode2
CD46 C4B 25361965 interaction type N/A PTMCode2
C4B CD46 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YES1 CD46 11901164 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DLG4 CD46 11714708 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
CD82 CD46 25348397 N/A physical interaction ComPPI
SRC CD46 10657632 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD81 CD46 24234451 25348397 30024968 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CD9 CD46 25348397 N/A physical interaction ComPPI
CD151 CD46 25348397 N/A physical interaction ComPPI
ITGB1 CD46 25348397 N/A physical interaction,in vivo ComPPI
C3 CD46 14525934 1717583 23086448 24234451 25348397 N/A experimental interaction detection,enzyme linked immunosorbent assay,in vitro ComPPI,HPRD,IntAct
MSN CD46 12082081 14525934 25348397 7884872 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITGA2 CD46 25348397 N/A physical interaction ComPPI
STK39 CD46 20694009 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
TSPAN4 CD46 10741407 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CD46 LLGL1 11714708 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CD46 TRIM16L 25348397 N/A physical interaction ComPPI
CD46 JAG1 23086448 24234451 25348397 colocalization nuclear magnetic resonance,surface plasmon resonance,enzyme linked immunosorbent assay,confocal microscopy ComPPI,IntAct
CD46 CD46 10357804 14525934 N/A experimental interaction detection HPRD
CD46 GIGYF2 24234451 30021884 physical association cross-linking study IntAct
SRC CD46 10657632 11901164 27898060 N/A N/A OmniPath
YES1 CD46 11901164 27898060 N/A N/A OmniPath
CD46 PTPN6 11858824 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B1C40 CD46 27087310 direct interaction,inhibition N/A NPInter

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