Gene Information gene info

  1. Home

GENE：CD8A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD8A
FullNmae CD8 subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1706
EnsembleID ENSG00000153563
Uniprot P01732

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD8A pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD8A immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature retulator signature

Go Annotation:

GeneSymbol Go id
CD8A GO:0002250,GO:0002456,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006955,GO:0007166,GO:0007169,GO:0009897,GO:0009897,GO:0015026,GO:0019882,GO:0019901,GO:0023024,GO:0042101,GO:0042110,GO:0042110,GO:0042110,GO:0042288,GO:0043235,GO:0043235,GO:0044853,GO:0045065,GO:0050852,GO:0050852

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD8A hsa:925 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CD8A hsa:925 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
CD8A hsa:925 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
CD8A hsa:925 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CD8A hsa:925 path:hsa05135 Yersinia infection - Homo sapiens (human)
CD8A hsa:925 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CD8A 20019798 8413295 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CD8A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CD8A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 CD8A 11937547 8413295 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SATB1 CD8A 11937547 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
FOXP3 CD8A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CD8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CD8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 CD8A N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 CD8A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000052E1A6 CD8A 23359619 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000052E1A6 CD8A 23359619 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237AF9 CD8A 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
C1QBP CD8A 25361965 interaction type N/A PTMCode2
CD8A C1QBP 25361965 interaction type N/A PTMCode2
CD8A CD3D 25361965 interaction type N/A PTMCode2
CD3D CD8A 25361965 interaction type N/A PTMCode2
CD8A LCK 25361965 interaction type N/A PTMCode2
LCK CD8A 25361965 interaction type N/A PTMCode2
CD8A HLA-G 25361965 interaction type N/A PTMCode2
HLA-G CD8A 25361965 interaction type N/A PTMCode2
CD8A PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD8A 25361965 interaction type N/A PTMCode2
CD8A HLA-A 25361965 interaction type N/A PTMCode2
HLA-A CD8A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LAT CD8A 10562325 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LCK CD8A 14500983 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD59 CD8A 25348397 N/A physical interaction ComPPI
COPA CD8A 25348397 N/A physical interaction ComPPI
SREK1 CD8A 14525934 14559993 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CACYBP CD8A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SRSF1 CD8A 10022843 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD3D CD8A 12215456 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD8A B2M 11914379 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD8A HLA-A 10809759 14525934 25348397 9177355 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD8A HLA-B 10809759 12853576 14525934 24234451 25348397 9331948 physical association experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
CD8A HLA-G 10809759 10843658 14525934 1908512 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD8A HLA-E 10809759 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD8A LGALS1 10490978 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD8A PTPRC 25348397 N/A physical interaction,in vivo ComPPI
CD8A HLA-C 10809759 12899833 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CD8A LNX1 25348397 N/A physical interaction ComPPI
CD8A CDK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LNX2 CD8A 25348397 N/A physical interaction ComPPI
CD8A CD8A 14525934 9177355 N/A experimental interaction detection HPRD
CD8A CALR 24234451 29997244 physical association luminescence based mammalian interactome mapping IntAct

Visualization










  Return