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GENE：CDK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDK4
FullNmae cyclin dependent kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1773
EnsembleID ENSG00000135446
Uniprot P11802

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDK4 mitotic_cd 37828444 DNA damage inhibits checkpoint kinase 1 (chk1) and cyclin-dependent kinase (CDK) 2, which in turn inhibits the recovery of cell cycle checkpoints and ultimately leads to mitotic catastrophe. retulator signature
CDK4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDK4 GO:0000082,GO:0000082,GO:0000082,GO:0000082,GO:0000307,GO:0000307,GO:0000785,GO:0004693,GO:0004693,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005829,GO:0005829,GO:0005923,GO:0006468,GO:0006468,GO:0007165,GO:0008284,GO:0009410,GO:0010033,GO:0010389,GO:0010468,GO:0010468,GO:0010971,GO:0016538,GO:0030332,GO:0030332,GO:0031965,GO:0048146,GO:0051301,GO:0051726,GO:0060260,GO:0061469,GO:0071222,GO:0071353,GO:0097128,GO:0097129,GO:0097130,GO:0106310,GO:1904628,GO:1904637

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDK4 hsa:1019 path:hsa01522 Endocrine resistance - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04110 Cell cycle - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04218 Cellular senescence - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04530 Tight junction - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
CDK4 hsa:1019 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05160 Hepatitis C - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05162 Measles - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05164 Influenza A - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05214 Glioma - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05218 Melanoma - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05219 Bladder cancer - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05224 Breast cancer - Homo sapiens (human)
CDK4 hsa:1019 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK4 SMAD3 10197981 12193595 15241418 16156666 26192618 interaction type N/A ACSN
CDK4 EGR1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDK4 LYN 17353931 23180781 physical association mass spectrometry studies of complexes InnateDB
IRF8 CDK4 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKB2 CDK4 23180781 25255445 physical association anti tag coimmunoprecipitation InnateDB
CCND1 CDK4 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
CDKN1C CDK4 20005715 interaction type N/A PSP
DBNL CDK4 20005715 interaction type N/A PSP
PRKAR1A CDK4 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 CDK4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CDK4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC CDK4 10688915 15208653 18414489 21384303 22395148 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CDK4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
USF1 CDK4 15208653 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
USF2 CDK4 15208653 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CDK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CDK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CDK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CDK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 CDK4 22179484 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 CDK4 22200613 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CDK4 18425349 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 CDK4 9154817 trascriptional regulation,stimulation inferred by curator TFlink
RELA CDK4 18425349 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 CDK4 22583549 trascriptional regulation,stimulation inferred by curator TFlink
SOX6 CDK4 21084391 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 CDK4 20651055 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CDK4 19017637 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CDK4 19017637 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 CDK4 22218594 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CDK4 17530187 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC CDK4 21750653 rna interference,inhibition experimental interaction detection miRSponge
URS00004F4657 CDK4 21092188 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000040EE1D CDK4 22289176 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000070CD2 CDK4 18710938 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 CDK4 17914404 19461653 21128241 rna interference,inhibition array technology,western blot,miRNA interference luciferase reporter assay miRSponge
URS000027352D CDK4 19461653 20924086 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002C7B2B CDK4 19461653 20924086 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001F5B39 CDK4 19833767 rna interference,inhibition western blot miRSponge
URS00003758F0 CDK4 19833767 rna interference,inhibition western blot miRSponge
URS00000EED18 CDK4 17914404 19461653 19890883 21128241 21240262 22743998 24504520 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000027352D CDK4 19461653 20924086 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B CDK4 19461653 20924086 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000070CD2 CDK4 18710938 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 CDK4 21092188 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000040EE1D CDK4 22289176 23544130 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00003758F0 CDK4 19833767 25416803 mrna cleavage,inhibition western blot TarBase
URS00001F5B39 CDK4 19833767 25416803 mrna cleavage,inhibition western blot TarBase
URS0000338542 CDK4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003380CC CDK4 21750653 23824327 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00001012BC CDK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 CDK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD CDK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C CDK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 CDK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000034B6F5 CDK4 24289491 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS00002E1509 CDK4 20371350 21572407 23446348 24398324 24505359 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00004AE8D3 CDK4 20371350 21572407 23446348 24398324 24604117 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000007D64A CDK4 23544130 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000003575B CDK4 23429262 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000076995 CDK4 25416803 25889078 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00005D986D CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 CDK4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 CDK4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B2B CDK4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000086A4D CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 CDK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D CDK4 25416803 26559153 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK7 CDK4 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
YES1 CDK4 22135298 phosphorylation N/A PhosphoSite
SRC CDK4 22135298 phosphorylation N/A PhosphoSite
CDK4 PELP1 22135298 phosphorylation N/A PhosphoSite
CDK4 RB1 22135298 phosphorylation N/A PhosphoSite
CDK4 RBL2 22135298 phosphorylation N/A PhosphoSite
CDK4 FOXM1 22135298 phosphorylation N/A PhosphoSite
CDK4 FOXO1 22135298 phosphorylation N/A PhosphoSite
CDK4 SMAD3 22135298 phosphorylation N/A PhosphoSite
CDK4 DNMT1 22135298 phosphorylation N/A PhosphoSite
CDK4 MEF2D 22135298 phosphorylation N/A PhosphoSite
CDK4 BRCA1 22135298 phosphorylation N/A PhosphoSite
CDK4 EGLN2 22135298 phosphorylation N/A PhosphoSite
CDK4 TCF3 22135298 phosphorylation N/A PhosphoSite
CDK4 WDR77 22135298 phosphorylation N/A PhosphoSite
CDK4 SOD2 22135298 phosphorylation N/A PhosphoSite
CDK4 MDM4 22135298 phosphorylation N/A PhosphoSite
CDK4 RUNX3 22135298 phosphorylation N/A PhosphoSite
CDK4 CELF1 22135298 phosphorylation N/A PhosphoSite
CDK4 RBL1 22135298 phosphorylation N/A PhosphoSite
CDK4 GATA4 22135298 phosphorylation N/A PhosphoSite
LYN CDK4 22135298 phosphorylation N/A PhosphoSite
CDC37 CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDC37 25361965 interaction type N/A PTMCode2
HSPA8 CDK4 25361965 interaction type N/A PTMCode2
CDK4 HSPA8 25361965 interaction type N/A PTMCode2
CDK4 CCND2 25361965 interaction type N/A PTMCode2
CCND2 CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN2C 25361965 interaction type N/A PTMCode2
CDKN2C CDK4 25361965 interaction type N/A PTMCode2
CDK4 MCM2 25361965 interaction type N/A PTMCode2
MCM2 CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN2A 25361965 interaction type N/A PTMCode2
CDKN2A CDK4 25361965 interaction type N/A PTMCode2
CDK4 CCNL1 25361965 interaction type N/A PTMCode2
CCNL1 CDK4 25361965 interaction type N/A PTMCode2
CDK4 IFI27 25361965 interaction type N/A PTMCode2
IFI27 CDK4 25361965 interaction type N/A PTMCode2
CDK4 BIRC5 25361965 interaction type N/A PTMCode2
BIRC5 CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN2D 25361965 interaction type N/A PTMCode2
CDKN2D CDK4 25361965 interaction type N/A PTMCode2
CDK4 CCND3 25361965 interaction type N/A PTMCode2
CCND3 CDK4 25361965 interaction type N/A PTMCode2
CDK4 PCNA 25361965 interaction type N/A PTMCode2
PCNA CDK4 25361965 interaction type N/A PTMCode2
CDK4 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C CDK4 25361965 interaction type N/A PTMCode2
CCND1 CDK4 25361965 interaction type N/A PTMCode2
CDK4 CCND1 25361965 interaction type N/A PTMCode2
CDKN1A CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN1A 25361965 interaction type N/A PTMCode2
MYOD1 CDK4 25361965 interaction type N/A PTMCode2
CDK4 MYOD1 25361965 interaction type N/A PTMCode2
CDKN1B CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN1B 25361965 interaction type N/A PTMCode2
CDK4 CDK7 25361965 interaction type N/A PTMCode2
PSMD10 CDK4 25361965 interaction type N/A PTMCode2
CDK4 PSMD10 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 CDK4 25348397 N/A physical interaction ComPPI
PPP1CC CDK4 25348397 N/A antibody array ComPPI
ATP5F1B CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCNA CDK4 25348397 N/A physical interaction ComPPI
CDKN1A CDK4 14525934 15232106 16962592 24234451 25348397 8756624 9106657 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,protein array,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
CCND1 CDK4 14525934 15232106 19075005 19237565 19470470 21242975 24218572 24234451 24855949 25241761 25348397 25416956 25910212 27107012 7568034 8756624 9106657 9150368 9837900 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,molecular sieving,protein array,x-ray crystallography,physical interaction,two hybrid array,protein kinase assay,in vitro,in vivo,lexa b52 complementation,proximity ligation assay,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
PPP2R1A CDK4 17540176 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDKN2C CDK4 14525934 17353931 21988832 23455922 23602568 24234451 25348397 25416956 25910212 27107012 8001816 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDK6 CDK4 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TK1 CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDKN1B CDK4 10908655 14525934 16326706 17053782 19470470 23602568 24234451 25241761 25348397 9106657 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
VCP CDK4 25348397 N/A physical interaction ComPPI
CDKN2D CDK4 14525934 16189514 23602568 24234451 25348397 25416956 25910212 27107012 7739548 association,physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
NOL12 CDK4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SKP1 CDK4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MCM2 CDK4 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDK5R1 CDK4 25348397 N/A physical interaction ComPPI
HSP90AB1 CDK4 22939624 23455922 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,luminescence based mammalian interactome mapping ComPPI,IntAct
RPRM CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DDIT4L CDK4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZNF219 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
SERTAD1 CDK4 10580009 14525934 15065884 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SP1 CDK4 25348397 N/A physical interaction ComPPI
NUP155 CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MYOD1 CDK4 10022835 10601020 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LYN CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SETDB1 CDK4 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RB1 CDK4 11254678 14525934 25348397 8626527 9003781 9139732 9190208 9315635 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD2 CDK4 14525934 15241418 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 CDK4 14525934 15241418 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
COPS5 CDK4 25348397 N/A physical interaction ComPPI
IRF8 CDK4 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GLI1 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
SORBS1 CDK4 25348397 N/A physical interaction ComPPI
CIB1 CDK4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IFI27 CDK4 14525934 25348397 9837900 N/A experimental interaction detection,in vivo ComPPI,HPRD
CUL3 CDK4 25348397 N/A physical interaction ComPPI
PRKAR1A CDK4 14525934 16582606 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CDKN2A CDK4 15232106 17353931 17517622 17909018 17955473 23455922 23602568 24234451 24855949 25348397 26496610 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,protein array,pull down,physical interaction,in vitro,in vivo,confocal microscopy,tandem affinity purification ComPPI,IntAct
UBTF CDK4 25348397 N/A physical interaction ComPPI
HSP90AA1 CDK4 23455922 24234451 25348397 association coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PGD CDK4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NTRK1 CDK4 25348397 N/A physical interaction ComPPI
VTN CDK4 25348397 N/A physical interaction ComPPI
PTPN1 CDK4 25348397 N/A physical interaction ComPPI
BAG6 CDK4 14525934 16169070 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RBL2 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDKN1C CDK4 14525934 24234451 25348397 9106657 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CDC6 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PSMA6 CDK4 25348397 N/A physical interaction ComPPI
PPP1CA CDK4 17274640 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
MYC CDK4 21988832 22094256 24234451 24951594 25348397 phosphorylation reaction,association,physical association two hybrid,physical interaction,two hybrid array,chromatin immunoprecipitation assay,protein kinase assay ComPPI,IntAct
PRMT5 CDK4 25348397 N/A physical interaction ComPPI
DBNL CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UHRF2 CDK4 21952639 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
IQGAP1 CDK4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP135 CDK4 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MARCKS CDK4 25348397 N/A physical interaction ComPPI
COPB2 CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RELA CDK4 25348397 N/A physical interaction ComPPI
PKM CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSC2 CDK4 24234451 25348397 26977878 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BCL11A CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
QARS1 CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
E2F4 CDK4 24234451 25348397 27173435 physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 CDK4 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NCOA2 CDK4 12130539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ZBTB16 CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CUL4B CDK4 25348397 N/A physical interaction ComPPI
ANKRD12 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
ARRB2 CDK4 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WDR77 CDK4 20951943 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC1A CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL1 CDK4 25348397 N/A physical interaction ComPPI
JAK3 CDK4 25348397 N/A physical interaction ComPPI
POLD1 CDK4 25348397 N/A physical interaction ComPPI
YBX3 CDK4 25348397 N/A physical interaction ComPPI
CDK7 CDK4 16327805 24234451 25348397 N/A physical interaction,protein kinase assay ComPPI,IntAct
MMS19 CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IKZF3 CDK4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTPN21 CDK4 25348397 N/A physical interaction ComPPI
BMPR1B CDK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KAT2A CDK4 24234451 24870244 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC3 CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS6 CDK4 25348397 N/A physical interaction ComPPI
UCHL1 CDK4 25348397 N/A physical interaction ComPPI
ATXN3 CDK4 25348397 N/A physical interaction ComPPI
MZF1 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
GUSB CDK4 25348397 N/A physical interaction ComPPI
TSPYL2 CDK4 25348397 N/A physical interaction ComPPI
PSMD10 CDK4 11779854 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EIF1AX CDK4 25348397 N/A physical interaction ComPPI
IL15RA CDK4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC45 CDK4 14525934 15232106 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAMK1 CDK4 25348397 N/A physical interaction ComPPI
CDC37 CDK4 14525934 17353931 21871133 24189400 24234451 25036637 25348397 27339980 8666233 8703009 9150368 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,electron tomography,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
ANKRA2 CDK4 25348397 N/A physical interaction ComPPI
CDC7 CDK4 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
SNCA CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OTX2 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CSTF3 CDK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDKN2B CDK4 14525934 16169070 16189514 19447967 21900206 23455922 23602568 24234451 25348397 25910212 26496610 7478582 9111314 9163429 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,bimolecular fluorescence complementation,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,HPRD,IntAct
BIRC5 CDK4 10713676 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GFER CDK4 25348397 N/A physical interaction ComPPI
NUP133 CDK4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 RFC4 10353443 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CDK4 BRCA1 14525934 25348397 9244350 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDK4 RFC1 10353443 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDK4 CEBPA 11684017 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDK4 RBL1 12006580 14525934 22094256 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vivo ComPPI,HPRD,IntAct
CDK4 VTA1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDK4 ZNF655 14525934 15558030 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
CDK4 CCND3 10342870 11896535 14525934 14641107 15232106 16189514 19237555 21516116 21988832 24234451 25348397 25416956 25910212 26496610 27107012 9106657 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,light scattering,molecular sieving,protein array,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDK4 CNOT7 25348397 N/A physical interaction,in vivo ComPPI
CDK4 ORC3 14525934 15232106 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDK4 CCND2 11896535 14525934 24234451 25348397 25910212 27107012 physical association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDK4 PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CDK4 CDKN2A 25348397 N/A physical interaction ComPPI
CDK4 ACTR3B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 GEMIN4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 UBXN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 SAP25 25348397 N/A physical interaction ComPPI
CDK4 CDT1 25348397 N/A physical interaction ComPPI
CDK4 ARID4A 25348397 N/A physical interaction ComPPI
CDK4 DAZAP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 HMGXB3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 TRMT2A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 LUC7L2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 HSP90AA2P 25348397 N/A physical interaction ComPPI
CDK4 H1-3 25348397 N/A physical interaction ComPPI
CDK4 PSMD9 25348397 N/A physical interaction ComPPI
CDK4 H1-1 25348397 N/A physical interaction ComPPI
CDK4 RPL34 25348397 N/A physical interaction ComPPI
CDK4 CCNE1 25348397 N/A physical interaction ComPPI
CDK4 CCNA2 25348397 N/A physical interaction ComPPI
CDK4 H1-0 25348397 N/A physical interaction ComPPI
CDK4 APP 25348397 N/A physical interaction ComPPI
CDK4 FOXM1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 SHOX2 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 SLBP 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 SENP3 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 WDR33 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 ZNF335 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 ZNF101 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CDK4 KLHL32 25348397 N/A physical interaction ComPPI
CDK4 PTMA 11310559 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CDK4 DUSP9 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDK4 MAPRE2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDK4 CDK13 23602568 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDK4 TARDBP 25348397 N/A physical interaction ComPPI
CDK4 FKBP5 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 HOOK1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,IntAct
CDK4 LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 RCAN3 25348397 N/A physical interaction ComPPI
CDK4 OGFR 25348397 N/A physical interaction ComPPI
CDK4 OGFRL1 25348397 N/A physical interaction ComPPI
CDK4 VSIG8 25348397 N/A physical interaction ComPPI
CDK4 SMTN 25348397 N/A physical interaction ComPPI
CDK4 ZNFX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 ZC3H14 25348397 N/A physical interaction ComPPI
CDK4 TMEM126A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 ASPM 17353931 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK4 UBXN10 25348397 N/A physical interaction ComPPI
CDK4 USP17L2 25348397 N/A physical interaction ComPPI
CDK4 FNIP1 25348397 N/A physical interaction ComPPI
CDK4 FNIP2 25348397 N/A physical interaction ComPPI
CDK4 MTMR14 25348397 N/A physical interaction ComPPI
CDK4 ASB12 25348397 N/A physical interaction ComPPI
CDK4 MTMR8 25348397 N/A physical interaction ComPPI
CDK4 DNAJC9 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDK4 GATA2 25348397 N/A physical interaction ComPPI
CDK4 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDK4 MTFP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDK4 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CDK4 OGDHL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDK4 INCA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDK4 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
CAPNS1 CDK4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LNX2 CDK4 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
DDAH2 CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDK4 SIN3B 24234451 24951594 association chromatin immunoprecipitation assay IntAct
IKBKG CDK4 24234451 30561431 association virotrap IntAct
YES1 CDK4 18479465 27898060 inhibition N/A OmniPath
LYN CDK4 17353931 18479465 27898060 N/A N/A OmniPath
CDK4 LYN 17353931 27898060 N/A N/A OmniPath
CDC25A CDK4 10454565 11585757 27898060 stimulant N/A OmniPath
CDK4 TCF3 11114297 27898060 N/A N/A OmniPath
CDKN1A CDK4 11967266 12383116 12970760 15169570 15232106 15695403 16962592 17556661 18729080 18850315 20102411 23443559 27898060 7626805 8622677 8756624 9106657 9464540 9632134 9658399 inhibition N/A OmniPath
CDK4 PRDX1 11986303 27898060 inhibition,stimulant N/A OmniPath
CDK4 RB1 10069453 10198259 10202152 10486249 10962560 11254678 11306463 11439341 11641415 11746527 11773438 11900540 12037672 12190313 12509456 12519773 12676926 12682072 12949733 14676836 15003538 15147269 15158336 15169570 15172998 15241418 15489884 15502804 15619620 15695403 15741232 15809340 15922743 15941859 15998794 16007177 16205633 16326706 16360038 16878158 16936279 16962592 16985050 17015477 17053782 17363486 17478427 17621266 18583321 18669648 18677112 19225156 19556892 19651622 19664994 19690332 20068231 20223825 20466538 21270107 21394082 21478909 22094256 22895174 23336272 23429262 23543736 23982736 24466208 24704824 24831015 24907662 25348716 25803170 26100623 26203195 27898060 8547220 8626527 8647086 8756624 8867812 9003781 9139732 9190208 9199321 9315635 9380698 9464540 inhibition,stimulant N/A OmniPath
CCND2 CDK4 11360184 11896535 15169570 17517622 26186194 27898060 9178893 9325318 stimulant N/A OmniPath
MYC CDK4 11602341 17093053 21988832 22094256 27898060 stimulant N/A OmniPath
CCND3 CDK4 10342870 11360184 11896535 14641107 15232106 16189514 16782892 16985050 17517622 19237555 21516116 21988832 23880157 25416956 26186194 26496610 27898060 9106657 9716181 stimulant N/A OmniPath
CDK4 MYOD1 10022835 10601020 21902831 27898060 inhibition N/A OmniPath
CDKN2C CDK4 11900540 16915296 17353931 21988832 23455922 23602568 25416956 26186194 27898060 8001816 8891723 inhibition N/A OmniPath
CDKN2D CDK4 16189514 16915296 23602568 23718855 25416956 26186194 27898060 7739548 inhibition,stimulant N/A OmniPath
CDKN2A CDK4 10491434 10580009 10585280 10719365 11556834 11900540 15065884 15232106 16161044 17353931 17517622 17881001 17909018 23455922 23602568 24855949 26186194 26496610 27898060 8259215 8805225 8891723 9228064 9529249 inhibition N/A OmniPath
CDK4 MEF2A 21902831 27898060 inhibition N/A OmniPath
CDK7 CDK4 14754892 16327805 27898060 8139570 stimulant N/A OmniPath
CDK4 RUNX3 19351720 27898060 inhibition N/A OmniPath
CDK4 BRCA1 12509456 17334399 27898060 9244350 inhibition N/A OmniPath
CDK4 CCND1 10580009 10908655 11360184 12036906 12519773 12588994 12970760 15232106 16102793 16331266 16627785 16985050 17081987 17205132 17420273 17699765 18537972 19075005 19237565 19470470 20516642 20837141 23707388 23718855 24218572 24855949 25241761 25416956 27898060 7568034 8259215 8662825 8756624 8867812 8978686 9106657 9150368 9178893 9228064 9372967 9837900 N/A N/A OmniPath
CCND1 CDK4 10580009 10908655 11360184 12036906 12519773 12588994 12970760 15232106 16102793 16331266 16627785 16985050 17081987 17205132 17420273 17517622 17699765 18537972 19075005 19237565 19470470 20516642 20837141 23562856 23707388 23718855 24218572 24855949 25241761 25416956 27898060 7568034 7736585 8259215 8662825 8756624 8867812 8978686 9106657 9150368 9178893 9228064 9372967 9837900 stimulant N/A OmniPath
CDK4 RBL2 11157749 12006580 12435635 21498570 22094256 27898060 inhibition N/A OmniPath
CDK4 RASSF1 18071316 27898060 inhibition N/A OmniPath
CDK4 RBL1 10069453 11884610 12006580 19664994 19664995 22094256 27898060 8643455 inhibition,stimulant N/A OmniPath
CDK4 SMAD3 15241418 15520018 19114991 19413330 20068231 25241761 27898060 inhibition N/A OmniPath
CDK4 FOXM1 22094256 27898060 stimulant N/A OmniPath
CDK4 MEF2D 21902831 25733682 27898060 inhibition N/A OmniPath
CDK4 SOD2 23243068 25578653 27898060 N/A N/A OmniPath
CDK4 MYOG 21902831 27898060 inhibition N/A OmniPath
CDKN2B CDK4 16169070 16189514 19447967 21900206 23455922 23602568 26186194 26496610 27898060 7478582 9042862 9111314 9163429 inhibition N/A OmniPath
CDK4 PELP1 20807815 27898060 stimulant N/A OmniPath
CDK4 UBTF 10202152 27898060 N/A N/A OmniPath
CDK4 MEF2C 21902831 27898060 inhibition N/A OmniPath
CDK4 CELF1 18570922 24151077 26100016 27898060 N/A N/A OmniPath
CDK4 GATA4 21447557 27898060 N/A N/A OmniPath

Visualization










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