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GENE：CFI

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CFI
FullNmae complement factor I
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5394
EnsembleID ENSG00000205403
Uniprot P05156

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CFI immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CFI GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006958,GO:0016020,GO:0045087,GO:0046872,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CFI hsa:3426 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
CFI hsa:3426 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
C3 CFI 16023208 2141838 23180781 cleavage reaction,protein cleavage protease assay InnateDB
CFI CD46 1386357 23180781 protein cleavage protease assay InnateDB
CFI C4B 1386357 23180781 protein cleavage protease assay InnateDB
CFI CR1 1386357 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 CFI 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF CFI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CFI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CFI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CFI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CFI 10630630 trascriptional regulation,stimulation inferred by curator TFlink
RELA CFI 10630630 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CFI 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 CFI 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
C3 CFI 25361965 interaction type N/A PTMCode2
CFI C3 25361965 interaction type N/A PTMCode2
CFH CFI 25361965 interaction type N/A PTMCode2
CFI CFH 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GLP1R CFI 25348397 N/A physical interaction ComPPI
C3 CFI 1401896 14525934 25348397 9291131 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ECM1 CFI 25348397 N/A physical interaction ComPPI
CFH CFI 1401896 14525934 25348397 9291131 N/A experimental interaction detection,in vitro ComPPI,HPRD

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