GENE：CISH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CISH |
| FullNmae | cytokine inducible SH2 containing protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1984 |
| EnsembleID | ENSG00000114737 |
| Uniprot | Q9NSE2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CISH | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CISH | GO:0001558,GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0005942,GO:0007205,GO:0009968,GO:0016567,GO:0035556,GO:0046854,GO:0046935 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CISH | hsa:1154 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| CISH | hsa:1154 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CUL2 | CISH | 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258 26192618 | interaction type | N/A | ACSN |
| RBX1 | CISH | 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258 26192618 | interaction type | N/A | ACSN |
| CISH | BCL2L11 | 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258 26192618 | interaction type | N/A | ACSN |
| EPOR | CISH | 23180781 9774439 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL2RB | CISH | 10514520 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CISH | STAT5A | 11713228 15652752 23180781 23331499 9742102 | stimulation,physical association | electrophoretic mobility supershift assay | InnateDB,SignaLink,SignaLink |
| CISH | STAT5B | 23180781 9742102 | physical association | electrophoretic mobility shift assay | InnateDB |
| PRLR | CISH | 11713228 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GHR | CISH | 10585430 23180781 24243840 29145629 | physical association | pull down,inferred by curator | InnateDB,Reactome |
| NFKBIA | CISH | 19596990 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GH1 | CISH | 24243840 29145629 | physical association | inferred by curator | Reactome |
| GH2 | CISH | 24243840 29145629 | physical association | inferred by curator | Reactome |
| CISH | PRLR | 11713228 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| CISH | LEPR | 18708154 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CISH | ERBB2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CISH | PRKCB | 20005715 | interaction type | N/A | PSP |
| CISH | IL2RB | 10514520 18988627 20005715 21071413 | interaction type | N/A | PSP,SignaLink |
| CISH | PRKCA | 20005715 | interaction type | N/A | PSP |
| CISH | CSF2RB | 20005715 | interaction type | N/A | PSP |
| CISH | PRKCQ | 20005715 | interaction type | N/A | PSP |
| CISH | CSF2RB | 20005715 20005715 | N/A | N/A | SignaLink |
| CISH | PRKCA | 12618484 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| CISH | PRKCB | 12618484 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| CISH | PRKCQ | 12618484 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | CISH | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | CISH | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CISH | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | CISH | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | CISH | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CISH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CISH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CISH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CISH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CISH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CISH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | CISH | 14630083 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT6 | CISH | 18342537 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | CISH | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001DA458 | CISH | 22660396 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS000016FD1A | CISH | 23723424 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GHR | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | GHR | 25361965 | interaction type | N/A | PTMCode2 |
| LEPR | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | LEPR | 25361965 | interaction type | N/A | PTMCode2 |
| CSF3R | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | CSF3R | 25361965 | interaction type | N/A | PTMCode2 |
| EPOR | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | EPOR | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| KIT | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | KIT | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB2 | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | ERBB2 | 25361965 | interaction type | N/A | PTMCode2 |
| INSR | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | INSR | 25361965 | interaction type | N/A | PTMCode2 |
| IL2RB | CISH | 25361965 | interaction type | N/A | PTMCode2 |
| CISH | IL2RB | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CUL5 | CISH | 25348397 | N/A | physical interaction | ComPPI |
| DYNLL1 | CISH | 18420585 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| BCL2L11 | CISH | 25348397 | N/A | physical interaction | ComPPI |
| RACK1 | CISH | 25348397 | N/A | physical interaction | ComPPI |
| ERBB2 | CISH | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| PRLR | CISH | 11713228 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PRKCQ | CISH | 12618484 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| KIT | CISH | 14525934 14707129 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PRKCA | CISH | 12618484 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| LCK | CISH | 25348397 | N/A | physical interaction | ComPPI |
| SMAD2 | CISH | 14525934 15231748 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| GHR | CISH | 12586763 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| UBC | CISH | 25348397 | N/A | physical interaction | ComPPI |
| CISH | PRKCB | 12618484 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CISH | IL3RA | 14525934 25348397 7796808 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CISH | CSF3R | 14525934 15470047 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CISH | CSF2RB | 14525934 25348397 7796808 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CISH | EPOR | 11781573 14525934 15644415 24234451 25348397 7796808 9774439 | physical association | two hybrid,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| CISH | IL2RB | 10514520 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CISH | MYD88 | 25348397 | N/A | physical interaction | ComPPI |
| CISH | ELOB | 25348397 | N/A | physical interaction | ComPPI |
| CISH | ELOC | 25348397 | N/A | physical interaction | ComPPI |
| CISH | CCNE1 | 25348397 | N/A | physical interaction | ComPPI |
| CISH | CCNC | 25348397 | N/A | physical interaction | ComPPI |
| CISH | CUL2 | 25348397 | N/A | physical interaction | ComPPI |
| CISH | EGFR | 16273093 24234451 24658140 25348397 | physical association | protein array,ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| CISH | ETV5 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CISH | HSPA6 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CISH | MAP3K7CL | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CISH | TBC1D10B | 25348397 | N/A | physical interaction | ComPPI |
| CISH | AMBRA1 | 25348397 | N/A | physical interaction | ComPPI |
| CISH | IL7R | 25348397 | N/A | physical interaction | ComPPI |
| ABL1 | CISH | 11274764 27898060 | N/A | N/A | OmniPath |
| EPOR | CISH | 11781573 15644415 16961462 27898060 7796808 9774439 | N/A | N/A | OmniPath |
| CISH | EPOR | 11781573 15644415 16961462 27898060 7796808 9774439 | N/A | N/A | OmniPath |
| CISH | STAT5A | 11713228 27898060 | inhibition,stimulant | N/A | OmniPath |
| CISH | LEPR | 18708154 27898060 | stimulant | N/A | OmniPath |
| NFKBIA | CISH | 19596990 27898060 | N/A | N/A | OmniPath |
| GHR | CISH | 10585430 12586763 25505247 27898060 | N/A | N/A | OmniPath |
| CISH | GHR | 10585430 12586763 25505247 27898060 | inhibition | N/A | OmniPath |
| CISH | PRLR | 11713228 27898060 | inhibition,stimulant | N/A | OmniPath |
| IL2RB | CISH | 10514520 27898060 | N/A | N/A | OmniPath |