GENE：CPOX
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CPOX |
| FullNmae | coproporphyrinogen oxidase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2321 |
| EnsembleID | ENSG00000080819 |
| Uniprot | P36551 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CPOX | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CPOX | GO:0004109,GO:0004109,GO:0005212,GO:0005737,GO:0005739,GO:0005758,GO:0005829,GO:0006782,GO:0006782,GO:0006783,GO:0016020,GO:0042803 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CPOX | hsa:1371 | path:hsa00860 | Porphyrin metabolism - Homo sapiens (human) |
| CPOX | hsa:1371 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CPOX | hsa:1371 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CPOX | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CPOX | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CPOX | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | CPOX | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CPOX | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | CPOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000ED600 | CPOX | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000CF1D2 | CPOX | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000122ED0 | CPOX | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000065D58 | CPOX | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000553F51 | CPOX | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000041CB9C | CPOX | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000042E1F | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001941B8 | CPOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | CPOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | CPOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | CPOX | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MCM2 | CPOX | 25348397 | N/A | physical interaction | ComPPI |
| JUN | CPOX | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CUL3 | CPOX | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | CPOX | 25348397 | N/A | physical interaction | ComPPI |
| BRCA1 | CPOX | 25348397 | N/A | physical interaction | ComPPI |
| AIFM1 | CPOX | 24234451 25348397 29568061 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| COX4I1 | CPOX | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| FH | CPOX | 25348397 | N/A | physical interaction | ComPPI |
| ATOH1 | CPOX | 25348397 | N/A | physical interaction | ComPPI |
| TCF4 | CPOX | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| SFXN1 | CPOX | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| SIRT4 | CPOX | 24234451 25348397 25525879 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CPOX | SCO1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |