GENE：CR2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CR2 |
| FullNmae | complement C3d receptor 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2336 |
| EnsembleID | ENSG00000117322 |
| Uniprot | P20023 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CR2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CR2 | GO:0001618,GO:0001848,GO:0002430,GO:0002456,GO:0003677,GO:0004875,GO:0004888,GO:0005515,GO:0005615,GO:0005886,GO:0005886,GO:0006955,GO:0006957,GO:0006958,GO:0016020,GO:0030183,GO:0034987,GO:0042100,GO:0042803,GO:0043235,GO:0045959,GO:0046718,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CR2 | hsa:1380 | path:hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| CR2 | hsa:1380 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| CR2 | hsa:1380 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| CR2 | hsa:1380 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| C3 | CR2 | 19164292 23180781 | physical association | nuclear magnetic resonance,solid phase assay | InnateDB |
| IFNA1 | CR2 | 19164292 23180781 | physical association | solid phase assay | InnateDB |
| CEBPB | CR2 | 19487031 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RBPJ | CR2 | 19487031 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CR2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | CR2 | 12695333 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NFKB1 | CR2 | 12444129 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| REL | CR2 | 12444129 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| RELA | CR2 | 12444129 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| RFX5 | CR2 | 12444129 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| TCF3 | CR2 | 11739509 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | CR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | CR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | CR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | CR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARID3A | CR2 | 19487031 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | CR2 | 19487031 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | CR2 | 19487031 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | CR2 | 19487031 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RBPJ | CR2 | 19487031 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SATB1 | CR2 | 19487031 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF7L1 | CR2 | 11739509 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD81 | CR2 | 25348397 | N/A | physical interaction | ComPPI |
| FHOD1 | CR2 | 14525934 15138285 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| HNRNPU | CR2 | 14525934 25348397 7753047 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| C3 | CR2 | 11684127 14525934 1830068 19164292 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| FCER2 | CR2 | 14525934 25348397 27898060 7515913 8766552 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| CR2 | CR1 | 14525934 1708808 25348397 27898060 7690834 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| CR2 | IFNA1 | 14525934 1849076 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CR2 | IFITM1 | 1383329 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CR2 | CD19 | 14525934 1702139 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CR2 | ANXA6 | 14525934 1831222 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| TP53 | CR2 | 14525934 7753047 | N/A | experimental interaction detection | HPRD |
| CR2 | CR2 | 11387479 14525934 | N/A | experimental interaction detection | HPRD |
| IFNA1 | CR2 | 1849076 19164292 27898060 | N/A | N/A | OmniPath |
| CR2 | IFNA1 | 1849076 19164292 27898060 | N/A | N/A | OmniPath |