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GENE：CREM

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CREM
FullNmae cAMP responsive element modulator
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2352
EnsembleID ENSG00000095794
Uniprot Q03060

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CREM immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CREM GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0006355,GO:0006357,GO:0006687,GO:0007165,GO:0007283,GO:0008140,GO:0030154,GO:0045944,GO:0048511,GO:1990589,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CREM hsa:1390 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL2 CREM 15841182 20694009 23180781 9545284 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
FOS CREM 18641343 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNG CREM 23180781 9545284 physical association electrophoretic mobility supershift assay InnateDB
CREM TNF 23180781 9545284 physical association electrophoretic mobility supershift assay InnateDB
CSF2 CREM 23180781 9545284 physical association electrophoretic mobility supershift assay InnateDB
IL4 CREM 23180781 9545284 physical association electrophoretic mobility supershift assay InnateDB
CREM IL2 17056544 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CREM 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CREM 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CREM 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CREM 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CREM 18971253 21757709 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CREM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN CREM 21757709 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CREM 21757709 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CREM 21757709 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000031E12 CREM 25074381 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00004977C5 CREM 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 CREM 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F CREM 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 CREM 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 CREM 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 CREM 22135298 phosphorylation N/A PhosphoSite
CDK1 CREM 22135298 phosphorylation N/A PhosphoSite
SPI1 CREM 25361965 interaction type N/A PTMCode2
CREM SPI1 25361965 interaction type N/A PTMCode2
CREM KCNIP3 25361965 interaction type N/A PTMCode2
KCNIP3 CREM 25361965 interaction type N/A PTMCode2
CREM FHL5 25361965 interaction type N/A PTMCode2
FHL5 CREM 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSNAX CREM 25348397 N/A physical interaction ComPPI
ATXN1 CREM 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
TBP CREM 10409662 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKCA CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SPI1 CREM 14525934 25348397 7730336 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK3 CREM 25348397 N/A physical interaction ComPPI
CREBBP CREM 14525934 25348397 27898060 9006899 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PRKACA CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3B CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CSNK2A1 CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAD18 CREM 25348397 N/A physical interaction ComPPI
CAMK2G CREM 25348397 N/A in vitro,in vivo ComPPI
SP100 CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CSNK2A2 CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CDC34 CREM 10373550 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
TAF4 CREM 10409662 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DNMT3A CREM 21976679 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
KCNIP3 CREM 11094064 12198160 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIAS3 CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3L CREM 25348397 N/A physical interaction ComPPI
ATF1 CREM 12805554 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP8AP2 CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EMP3 CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FOXL2 CREM 25348397 N/A physical interaction ComPPI
FHL5 CREM 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
CREM CREB1 14525934 24234451 25348397 25609649 7809053 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CREM CREB3L1 12805554 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CREM HDAC1 17056544 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
CREM CREB3L4 25348397 N/A physical interaction ComPPI
CREM RBPJ 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CREM MIA2 25348397 N/A physical interaction ComPPI
CDK1 CREM 14525934 8404858 N/A experimental interaction detection HPRD
CREM CREM 14525934 8994192 N/A experimental interaction detection HPRD
CSNK1A1 CREM 14525934 8404858 N/A experimental interaction detection HPRD
PRKACA CREM 27898060 8404858 N/A N/A OmniPath
PRKCA CREM 27898060 8404858 N/A N/A OmniPath
CSNK1A1 CREM 27898060 8404858 N/A N/A OmniPath
CREM CREB1 1847666 22531917 25609649 27898060 7809053 inhibition N/A OmniPath
CDK2 CREM 27898060 8404858 N/A N/A OmniPath
GSK3A CREM 27898060 8404858 N/A N/A OmniPath
CDK1 CREM 11466319 21767532 27898060 8404858 N/A N/A OmniPath
CSNK2A1 CREM 27898060 8404858 N/A N/A OmniPath
GSK3B CREM 27898060 8404858 N/A N/A OmniPath
RPS6KB1 CREM 27898060 7923380 stimulant N/A OmniPath
CREM KCNIP3 11094064 12198160 27898060 inhibition N/A OmniPath
CAMK4 CREM 27898060 7799965 8523736 stimulant N/A OmniPath
CSNK2A2 CREM 27898060 8404858 N/A N/A OmniPath
CAMK2G CREM 27898060 8404858 N/A N/A OmniPath
FHL5 CREM 10086359 11046156 27898060 stimulant N/A OmniPath
CAMK2D CREM 27898060 8404858 N/A N/A OmniPath

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