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GENE：CTLA4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTLA4
FullNmae cytotoxic T-lymphocyte associated protein 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2505
EnsembleID ENSG00000163599
Uniprot P16410

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTLA4 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature

Go Annotation:

GeneSymbol Go id
CTLA4 GO:0002250,GO:0005515,GO:0005794,GO:0005886,GO:0005886,GO:0006955,GO:0006974,GO:0009897,GO:0009897,GO:0030889,GO:0042130,GO:0043065,GO:0045334,GO:0045590,GO:0045590,GO:0048471,GO:0050852,GO:0050853,GO:0050853,GO:0098636

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTLA4 hsa:1493 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CTLA4 hsa:1493 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CTLA4 hsa:1493 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
CTLA4 hsa:1493 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTLA4 CD28 10921877 11093160 12370081 16227604 16885030 16916641 18292600 19890961 21159657 21376459 22116087 22437870 26192618 interaction type N/A ACSN
CD86 CTLA4 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 26192618 7523569 8920882 9359474 interaction type N/A ACSN
CD80 CTLA4 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26192618 26405600 7512027 7523569 9359474 interaction type N/A ACSN
ADORA2A CTLA4 17371980 17909080 18758473 26192618 interaction type N/A ACSN
FOXP3 CTLA4 12522256 17237765 17449799 21411734 26192618 interaction type N/A ACSN
STAT5A CTLA4 16476059 23180781 physical association two hybrid InnateDB
AP2M1 CTLA4 16476059 23180781 physical association two hybrid InnateDB
CTLA4 CD80 21422170 23180781 physical association x-ray crystallography InnateDB
CTLA4 PTPN6 23109003 9256472 chemical activation reaction N/A SignaLink
CTLA4 PTPA 16227604 19405949 23109003 chemical activation reaction N/A SignaLink
CTLA4 PTPN11 11905831 15790353 16107703 23109003 chemical activation reaction N/A SignaLink
CTLA4 CBLB 16860761 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
NFATC2 CTLA4 17785820 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CTLA4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CTLA4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
EGR1 CTLA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 CTLA4 16297665 trascriptional regulation,stimulation inferred by curator TFlink
MSC CTLA4 19561533 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CTLA4 19193853 25416803 mrna cleavage,inhibition array technology TarBase
URS0000427B68 CTLA4 21572407 22012620 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB CTLA4 21572407 22012620 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TMEM218 CTLA4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MALL CTLA4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LYN CTLA4 14525934 25348397 9712716 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3R1 CTLA4 14525934 24234451 25348397 7807015 9398332 9813138 association coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 CTLA4 14525934 25348397 8638161 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LCK CTLA4 14525934 25348397 9712716 9973379 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAB8A CTLA4 24234451 24515439 25348397 colocalization fluorescence microscopy ComPPI,IntAct
AP1M1 CTLA4 11583591 14525934 25348397 9812899 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP2R5A CTLA4 11994459 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
STAT5A CTLA4 14525934 16476059 24234451 25241761 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
STAT5B CTLA4 14525934 16476059 24234451 25241761 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
CD86 CTLA4 11279501 21982860 24234451 25241761 25348397 physical association protein array,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
JAK2 CTLA4 10842319 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAPGEF1 CTLA4 24234451 24396067 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXK CTLA4 14525934 25348397 9813138 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LAX1 CTLA4 24234451 24515439 25348397 colocalization fluorescence microscopy ComPPI,IntAct
FYN CTLA4 14525934 24234451 25241761 25348397 9712716 9973379 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CD274 CTLA4 20587542 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
AP2M1 CTLA4 11583591 14525934 16476059 25348397 27898060 9200449 9256472 9812899 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TRIM25 CTLA4 24234451 24515439 25348397 colocalization fluorescence microscopy ComPPI,IntAct
CTLA4 CD80 11279502 14525934 20587542 21982860 24234451 25348397 7545666 physical association experimental interaction detection,fluorescence-activated cell sorting,protein array,surface plasmon resonance,x-ray crystallography,physical interaction ComPPI,HPRD,IntAct
CTLA4 ELAVL1 25348397 N/A physical interaction ComPPI
CTLA4 LRBA 24234451 25348397 26206937 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTLA4 CTXN3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CTLA4 CTLA4 11279501 14525934 N/A experimental interaction detection HPRD
LCK CTLA4 27898060 9712716 9973379 inhibition,stimulant N/A OmniPath
FYN CTLA4 25241761 27898060 9712716 9973379 inhibition,stimulant N/A OmniPath
CTLA4 CD80 11279502 21422170 21982860 27898060 7545666 N/A N/A OmniPath
CD80 CTLA4 11279502 21422170 21982860 27898060 7545666 stimulant N/A OmniPath
CTLA4 STAT5A 16476059 25241761 27898060 N/A N/A OmniPath
JAK2 CTLA4 10842319 27898060 inhibition,stimulant N/A OmniPath
TXK CTLA4 27898060 9175836 9813138 stimulant N/A OmniPath

Visualization










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