GENE：CYP11A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CYP11A1 |
| FullNmae | cytochrome P450 family 11 subfamily A member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2590 |
| EnsembleID | ENSG00000140459 |
| Uniprot | P05108 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CYP11A1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CYP11A1 | GO:0005506,GO:0005515,GO:0005739,GO:0005743,GO:0005743,GO:0005759,GO:0006700,GO:0006700,GO:0006700,GO:0006704,GO:0008203,GO:0008203,GO:0008203,GO:0008203,GO:0008203,GO:0008386,GO:0008386,GO:0008386,GO:0008386,GO:0016125,GO:0020037,GO:0034650,GO:0042359,GO:0071375 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CYP11A1 | hsa:1583 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| CYP11A1 | hsa:1583 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CYP11A1 | hsa:1583 | path:hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| CYP11A1 | hsa:1583 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| CYP11A1 | hsa:1583 | path:hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| CYP11A1 | hsa:1583 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CYP11A1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CYP11A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CYP11A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | CYP11A1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CYP11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CYP11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CYP11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | CYP11A1 | 11057754 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXL2 | CYP11A1 | 21862621 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA6 | CYP11A1 | 15284005 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GRHL1 | CYP11A1 | 18004979 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | CYP11A1 | 11057754 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR4A1 | CYP11A1 | 20083153 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR5A1 | CYP11A1 | 11057754 19477906 23530236 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR5A2 | CYP11A1 | 19067654 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SF1 | CYP11A1 | 19477906 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | CYP11A1 | 10446912 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFCP2L1 | CYP11A1 | 18004979 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| UBP1 | CYP11A1 | 18004979 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | CYP11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | CYP11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CYP11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | CYP11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | CYP11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000568FF8 | CYP11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023133F | CYP11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C3F6 | CYP11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F9738 | CYP11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | CYP11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171020 | CYP11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMAD2 | CYP11A1 | 14525934 15231748 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| SMAD3 | CYP11A1 | 14525934 15231748 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| SMAD9 | CYP11A1 | 15231748 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CYP11A1 | FDX1 | 1429635 14525934 1917982 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| CYP11A1 | A2M | 17174955 24234451 25348397 | colocalization | cosedimentation through density gradient | ComPPI,IntAct |