GENE：DDC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DDC |
| FullNmae | dopa decarboxylase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2719 |
| EnsembleID | ENSG00000132437 |
| Uniprot | P20711 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DDC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DDC | GO:0004058,GO:0004058,GO:0005515,GO:0005737,GO:0005829,GO:0006520,GO:0006584,GO:0009636,GO:0019899,GO:0030170,GO:0036467,GO:0036468,GO:0042416,GO:0042427,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DDC | hsa:1644 | path:hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa00360 | Phenylalanine metabolism - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa05030 | Cocaine addiction - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| DDC | hsa:1644 | path:hsa05034 | Alcoholism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| JRA | DDC | 19168633 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| KAY | DDC | 19168633 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| KAY | DDC | 19168633 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| AR | DDC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | DDC | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | DDC | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | DDC | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | DDC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| BR | DDC | 8582299 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BR | DDC | 8582299 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DDC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU3F2 | DDC | 9602135 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU5F1 | DDC | 9602135 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DDC | 12864730 14525934 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,in vivo,reverse two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| RELA | DDC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ATF6 | DDC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| DDC | BSG | 25348397 | N/A | physical interaction | ComPPI |
| AR | DDC | 12864730 17721441 27898060 | stimulant | N/A | OmniPath |