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GENE：DDR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DDR1
FullNmae discoidin domain receptor tyrosine kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2730
EnsembleID ENSG00000204580
Uniprot Q08345

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DDR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DDR1 GO:0001558,GO:0001952,GO:0004714,GO:0005515,GO:0005518,GO:0005518,GO:0005518,GO:0005524,GO:0005615,GO:0005886,GO:0007155,GO:0007169,GO:0007275,GO:0007566,GO:0007595,GO:0008285,GO:0010715,GO:0010976,GO:0014909,GO:0033674,GO:0038062,GO:0038062,GO:0038063,GO:0038063,GO:0038083,GO:0043235,GO:0043235,GO:0043583,GO:0044319,GO:0046777,GO:0046872,GO:0051897,GO:0060444,GO:0060749,GO:0061302,GO:0061564,GO:0070062,GO:1990138

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DDR1 COL1A1 21815193 23180781 physical association solid phase assay InnateDB
DDR1 SHC1 23331499 9659899 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 DDR1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 DDR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DDR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 DDR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP63 DDR1 17521434 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 DDR1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF DDR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DDR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DDR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DDR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DDR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DDR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000029EBD DDR1 22374871 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 DDR1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000029979D DDR1 25416803 25972194 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002EF20A DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CC864 DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000183BED DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002578DA DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 DDR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075E2C3 DDR1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000010BD8D DDR1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDAA DDR1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NEK6 DDR1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NCK2 DDR1 14525934 16337946 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,two hybrid ComPPI,HPRD,IntAct
TTR DDR1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COL1A2 DDR1 25348397 N/A enzyme linked immunosorbent assay ComPPI
PTPN11 DDR1 14525934 16337946 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
SHC1 DDR1 10783152 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FRS2 DDR1 10783152 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HSP90AA1 DDR1 25348397 N/A physical interaction ComPPI
DDR1 TM4SF1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DDR1 COL2A1 14525934 25348397 9659900 N/A experimental interaction detection,in vivo ComPPI,HPRD
DDR1 RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DDR1 SNAPIN 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DDR1 COL3A1 14525934 25348397 9659900 N/A experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vivo,solid phase assay ComPPI,HPRD
DDR1 COL5A2 14525934 25348397 9659900 N/A experimental interaction detection,in vivo ComPPI,HPRD
DDR1 COL11A1 14525934 25348397 9659900 N/A experimental interaction detection,in vivo ComPPI,HPRD
DDR1 SNRNP40 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DDR1 BEND5 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DDR1 COL1A1 25348397 N/A enzyme linked immunosorbent assay ComPPI
DDR1 NUDT3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DDR1 HSP90AA2P 25348397 N/A physical interaction ComPPI
DDR1 MOV10 25348397 N/A physical interaction ComPPI
DDR1 NXF1 25348397 N/A physical interaction ComPPI
DDR1 CDH1 25348397 N/A physical interaction ComPPI
DDR1 CDH2 25348397 N/A physical interaction ComPPI
DDR1 CDC37 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DDR1 TNFRSF10B 25348397 N/A physical interaction ComPPI
DDR1 HNRNPL 25348397 N/A physical interaction ComPPI
DDR1 IRS1 25348397 N/A protein kinase assay ComPPI
DDR1 UBQLN2 25348397 N/A two hybrid ComPPI
MAPK6 DDR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DDR1 PLCG1 10783152 14525934 N/A experimental interaction detection HPRD
DDR1 DDR1 14525934 9659899 N/A experimental interaction detection HPRD
DDR1 WWC1 18190796 27898060 N/A N/A OmniPath
DDR1 CDK2 1396589 14597612 16325401 17095507 17192257 17570665 19690332 20147522 20360007 21565702 27898060 N/A N/A OmniPath
TP53 DDR1 18431400 27898060 stimulant N/A OmniPath
DDR1 SHC1 10783152 27898060 9659899 stimulant N/A OmniPath
DDR1 CDK1 16565220 17924679 18220336 18691976 19369195 19690332 20360007 27898060 N/A N/A OmniPath
COL1A1 DDR1 21044884 21815193 27898060 9659900 stimulant N/A OmniPath
TNK2 DDR1 12023960 27898060 9659899 N/A N/A OmniPath

Visualization










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