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GENE：DES

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DES
FullNmae desmin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2770
EnsembleID ENSG00000175084
Uniprot P17661

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DES immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DES GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005882,GO:0005911,GO:0005916,GO:0006936,GO:0007010,GO:0008016,GO:0008092,GO:0014704,GO:0030018,GO:0030018,GO:0031594,GO:0042383,GO:0042383,GO:0042802,GO:0045109,GO:0045111,GO:0060538,GO:0070062,GO:0097512

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DES hsa:1674 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
DES hsa:1674 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
DES hsa:1674 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DES UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR DES 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
MYOD1 DES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TBP DES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM16 DES 22009481 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 DES N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKACA DES 22135298 phosphorylation N/A PhosphoSite
ROCK1 DES 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AURKB DES 22135298 phosphorylation N/A PhosphoSite
S100B DES 25361965 interaction type N/A PTMCode2
DES S100B 25361965 interaction type N/A PTMCode2
DES DSP 25361965 interaction type N/A PTMCode2
DSP DES 25361965 interaction type N/A PTMCode2
DES ROCK1 25361965 interaction type N/A PTMCode2
DES NEB 25361965 interaction type N/A PTMCode2
NEB DES 25361965 interaction type N/A PTMCode2
DES SYNC 25361965 interaction type N/A PTMCode2
SYNC DES 25361965 interaction type N/A PTMCode2
SYNM DES 25361965 interaction type N/A PTMCode2
DES SYNM 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMO4 DES 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LENG1 DES 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPL DES 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIAS2 DES 25348397 N/A two hybrid ComPPI
DDX6 DES 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2I DES 25348397 N/A physical interaction ComPPI
C1ORF216 DES 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES SHBG 14525934 15862967 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DES CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DES TRIM7 11916970 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DES NEB 12064939 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
DES DSP 14525934 25348397 9261168 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
DES S100A1 14525934 25348397 27898060 8641565 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
DES S100B 10510252 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DES SPTAN1 14525934 25348397 27898060 2939097 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
DES PKD1 11581269 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
DES ROCK1 10574968 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DES AURKB 12686604 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DES SYNM 11353857 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DES SYNC 11694502 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
DES PLEKHA5 25348397 N/A physical interaction ComPPI
DES YWHAQ 25348397 N/A physical interaction ComPPI
DES ITSN1 25348397 N/A physical interaction ComPPI
DES SP1 25348397 N/A physical interaction ComPPI
DES CRYAB 25348397 N/A physical interaction ComPPI
DES HNRNPUL1 25348397 N/A physical interaction ComPPI
DES RPL29 25348397 N/A physical interaction ComPPI
DES SNRNP70 25348397 N/A physical interaction ComPPI
DES HADHB 25348397 N/A physical interaction ComPPI
DES CCT7 25348397 N/A physical interaction ComPPI
DES MYL6 25348397 N/A physical interaction ComPPI
DES RPL17 25348397 N/A physical interaction ComPPI
DES JUP 25348397 N/A physical interaction ComPPI
DES MLH1 20706999 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
DES MAPKAPK2 25348397 N/A physical interaction ComPPI
DES TRIM63 18157088 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DES TRIM55 25348397 N/A physical interaction ComPPI
DES EHHADH 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DES PPP1R18 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DES MOV10 25348397 N/A physical interaction ComPPI
DES BRCA1 25348397 N/A physical interaction ComPPI
DES HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
DES GLI1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
DES NEFM 25348397 N/A physical interaction ComPPI
DES GFAP 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES VIM 24234451 25348397 27107012 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
DES SPATA22 25348397 N/A physical interaction ComPPI
DES DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DES PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DES SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DES CFTR 25348397 N/A physical interaction ComPPI
DES SAP18 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DES SMURF2 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
DES YWHAZ 20618440 24234451 25348397 association tandem affinity purification ComPPI,IntAct
DES DYSF 23414517 24234451 25348397 colocalization,physical association two hybrid fragment pooling approach,confocal microscopy,proximity ligation assay ComPPI,IntAct
DES CLIP4 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
DES ENO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
DES SNAPIN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
DES ATF2 22304920 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DES PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DES MTM1 21135508 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation,cosedimentation in solution,far western blotting,filter binding,pull down,confocal microscopy ComPPI,IntAct,OmniPath
DES JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
DES NEFL 24234451 25348397 26871637 27107012 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,IntAct
DES DUX1 24234451 25348397 26816005 physical association two hybrid,pull down ComPPI,IntAct
DES DUX4L9 24234451 25348397 26816005 colocalization,physical association two hybrid,fluorescence microscopy,proximity ligation assay ComPPI,IntAct
DES DUX4 24234451 25348397 26816005 physical association pull down,proximity ligation assay ComPPI,IntAct
DES KRT15 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES TFIP11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES KRT33B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES PIH1D2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES PRPH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES M1AP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES CT55 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES BAG5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES YES1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES KRT20 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES TCEA2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES LONRF3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES CWF19L2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES SUMO1P1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES KRT13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES POLR2G 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES KRT37 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES KRT75 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES RNF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES LBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DES STAT1 24234451 25348397 26966684 association pull down ComPPI,IntAct
DES DES 21135508 24234451 physical association cosedimentation,two hybrid array,electrophoretic mobility-based method,two hybrid prey pooling approach IntAct
AURKB DES 10574968 12686604 15630414 27898060 stimulant N/A OmniPath
ROCK1 DES 10574968 27898060 N/A N/A OmniPath

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