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GENE：EDNRA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EDNRA
FullNmae endothelin receptor type A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3179
EnsembleID ENSG00000151617
Uniprot P25101

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EDNRA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EDNRA GO:0000278,GO:0001569,GO:0001666,GO:0001701,GO:0001974,GO:0001975,GO:0002027,GO:0003094,GO:0003207,GO:0003220,GO:0003228,GO:0003253,GO:0003357,GO:0004435,GO:0004962,GO:0004962,GO:0005515,GO:0005886,GO:0005886,GO:0006874,GO:0006939,GO:0007005,GO:0007165,GO:0007186,GO:0007190,GO:0007193,GO:0007202,GO:0007204,GO:0007249,GO:0007585,GO:0008217,GO:0008283,GO:0009611,GO:0010467,GO:0010737,GO:0010827,GO:0014034,GO:0014824,GO:0016322,GO:0030202,GO:0030878,GO:0034599,GO:0035050,GO:0035904,GO:0042310,GO:0042310,GO:0042415,GO:0042474,GO:0044751,GO:0048066,GO:0048484,GO:0048485,GO:0048675,GO:0048706,GO:0050905,GO:0055078,GO:0060070,GO:0060324,GO:0060385,GO:0061028,GO:0061626,GO:0070294,GO:0070588,GO:0071372,GO:0071373,GO:0071806,GO:0072011,GO:0072112,GO:0086100,GO:0086101,GO:0097018,GO:0097084,GO:0097152,GO:0097492,GO:1902287,GO:1903210,GO:1903537,GO:1904888,GO:1905144,GO:1905871,GO:2001259

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EDNRA hsa:1909 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
EDNRA hsa:1909 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
EDNRA hsa:1909 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
EDNRA hsa:1909 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
EDNRA hsa:1909 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
EDNRA hsa:1909 path:hsa04924 Renin secretion - Homo sapiens (human)
EDNRA hsa:1909 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR EDNRA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA EDNRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EDNRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EDNRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171525 EDNRA 23272142 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB EDNRA 20827281 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000184017 EDNRA 20827281 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000330617 EDNRA 20827281 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB EDNRA 20827281 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 EDNRA 20827281 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000184017 EDNRA 20827281 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 EDNRA 23272142 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
EDNRA SRC 25361965 interaction type N/A PTMCode2
SRC EDNRA 25361965 interaction type N/A PTMCode2
GNA11 EDNRA 25361965 interaction type N/A PTMCode2
EDNRA GNA11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BCL2L11 EDNRA 25348397 N/A physical interaction ComPPI
VPS11 EDNRA 25348397 N/A physical interaction ComPPI
SRC EDNRA 19202075 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS5 EDNRA 20034471 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MCL1 EDNRA 25348397 N/A physical interaction ComPPI
GRK6 EDNRA 14525934 25348397 9211925 N/A experimental interaction detection,in vitro ComPPI,HPRD
ARRB1 EDNRA 19202075 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MT-ND1 EDNRA 25348397 N/A physical interaction ComPPI
ARRB2 EDNRA 19202075 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EDN1 EDNRA 10770212 14525934 23597562 24234451 25348397 physical association experimental interaction detection,scintillation proximity assay,physical interaction,in vivo ComPPI,HPRD,IntAct
EBP EDNRA 25348397 N/A physical interaction ComPPI
MT-CO1 EDNRA 25348397 N/A physical interaction ComPPI
HDAC7 EDNRA 25348397 N/A physical interaction ComPPI
GNA11 EDNRA 10789830 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EDN3 EDNRA 11982704 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GNAI2 EDNRA 14525934 25348397 7882989 N/A experimental interaction detection,in vivo ComPPI,HPRD
MTX1 EDNRA 25348397 N/A physical interaction ComPPI
ARL5B EDNRA 25348397 N/A physical interaction ComPPI
KAT5 EDNRA 11262386 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
EDNRA SYNGR2 25348397 N/A physical interaction ComPPI
EDNRA LMBR1 25348397 N/A physical interaction ComPPI
EDNRA PXMP2 25348397 N/A physical interaction ComPPI
EDNRA VKORC1L1 25348397 N/A physical interaction ComPPI
EDNRA GNAQ 15475516 27898060 stimulant N/A OmniPath
EDNRA GNA13 10199825 27898060 stimulant N/A OmniPath
EDN1 EDNRA 10770212 16597412 23597562 27898060 9082970 stimulant N/A OmniPath

Visualization










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