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GENE：EHMT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EHMT1
FullNmae euchromatic histone lysine methyltransferase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24650
EnsembleID ENSG00000181090
Uniprot Q9H9B1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EHMT1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EHMT1 GO:0000122,GO:0000785,GO:0001222,GO:0002039,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006306,GO:0006306,GO:0006325,GO:0008168,GO:0008270,GO:0016279,GO:0016604,GO:0018026,GO:0018027,GO:0018027,GO:0045892,GO:0045995,GO:0046974,GO:0046974,GO:0046974,GO:0046976,GO:0051570,GO:0060992,GO:0070742,GO:0120162,GO:0140718,GO:0140947

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EHMT1 hsa:79813 path:hsa00310 Lysine degradation - Homo sapiens (human)
EHMT1 hsa:79813 path:hsa01100 Metabolic pathways - Homo sapiens (human)
EHMT1 hsa:79813 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RELA EHMT1 21131967 23180781 physical association anti tag coimmunoprecipitation InnateDB
CXCL8 EHMT1 21131967 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYC EHMT1 21131967 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR EHMT1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EHMT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 EHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 EHMT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE EHMT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001DE669 EHMT1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TFAP4 EHMT1 25348397 N/A physical interaction ComPPI
CDC5L EHMT1 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GMNN EHMT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCBD1 EHMT1 25348397 N/A physical interaction ComPPI
ATXN1 EHMT1 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
BMI1 EHMT1 25348397 N/A physical interaction ComPPI
XAGE3 EHMT1 25348397 N/A physical interaction ComPPI
XAGE2 EHMT1 25348397 N/A physical interaction ComPPI
EHMT2 EHMT1 21258344 24234451 25348397 26028330 27705803 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
EZH2 EHMT1 25348397 N/A physical interaction ComPPI
CBX1 EHMT1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
SETDB1 EHMT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
CTBP1 EHMT1 25348397 N/A physical interaction ComPPI
CTBP2 EHMT1 25348397 N/A physical interaction ComPPI
HNRNPL EHMT1 25348397 N/A physical interaction ComPPI
RELA EHMT1 21131967 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SUV39H1 EHMT1 25348397 N/A anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
MDM2 EHMT1 25348397 N/A physical interaction ComPPI
MPHOSPH8 EHMT1 20871592 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBX5 EHMT1 20562864 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H3-4 EHMT1 25348397 N/A physical interaction ComPPI
HTT EHMT1 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
HDAC2 EHMT1 21258344 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK7 EHMT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DNMT3A EHMT1 25348397 N/A physical interaction ComPPI
EED EHMT1 22659877 24457600 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HIF1AN EHMT1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CDK8 EHMT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H3C1 EHMT1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
H3-3A EHMT1 25348397 N/A physical interaction ComPPI
NKX3-1 EHMT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
LIG1 EHMT1 25348397 N/A physical interaction ComPPI
L3MBTL1 EHMT1 25348397 N/A physical interaction ComPPI
LZTR1 EHMT1 25348397 N/A physical interaction ComPPI
JARID2 EHMT1 25348397 N/A physical interaction ComPPI
SUV39H2 EHMT1 25348397 N/A physical interaction ComPPI
SIRT6 EHMT1 25348397 N/A physical interaction ComPPI
WIZ EHMT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
EHMT1 TRIM15 25348397 N/A physical interaction ComPPI
EHMT1 TP53 25348397 N/A physical interaction ComPPI
EHMT1 BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EHMT1 SMARCAD1 25348397 N/A physical interaction ComPPI
EHMT1 PRDM6 25348397 N/A physical interaction ComPPI
EHMT1 MIER2 25348397 N/A physical interaction ComPPI
EHMT1 H2BC1 25348397 N/A physical interaction ComPPI
EHMT1 ZBTB46 25348397 N/A physical interaction ComPPI
EHMT1 PPP4R3A 25348397 N/A physical interaction ComPPI
EHMT1 HDAC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EHMT1 HASPIN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EHMT1 ZNF644 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EHMT1 ZNF462 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
EHMT1 CBX3 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
MAD2L2 EHMT1 24234451 29789392 association anti tag coimmunoprecipitation IntAct
EHMT1 H3C1 19010785 20084102 20118233 27898060 inhibition N/A OmniPath
EHMT1 TP53 20118233 20588255 27898060 N/A N/A OmniPath
JARID2 EHMT1 19010785 27898060 stimulant N/A OmniPath
RELA EHMT1 21131967 27898060 N/A N/A OmniPath
EHMT1 RELA 21131967 27898060 N/A N/A OmniPath
EHMT1 CCND1 19010785 27898060 stimulant N/A OmniPath

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