GENE：EPHA3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EPHA3 |
| FullNmae | EPH receptor A3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3387 |
| EnsembleID | ENSG00000044524 |
| Uniprot | P29320 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EPHA3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EPHA3 | GO:0005003,GO:0005004,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0005886,GO:0006468,GO:0007155,GO:0007411,GO:0010717,GO:0010976,GO:0015629,GO:0016477,GO:0018108,GO:0030425,GO:0031965,GO:0032956,GO:0043087,GO:0045806,GO:0048013,GO:0048013,GO:0051893,GO:0070507,GO:0071300,GO:0097155,GO:0097156,GO:1903078 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EPHA3 | hsa:2042 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRPK1 | EPHA3 | 23180781 23602568 | phosphorylation reaction | protein kinase assay | InnateDB |
| EFNA1 | EPHA3 | 18988627 21071413 23331499 8070404 9195962 9576626 | stimulation | N/A | SignaLink,SignaLink |
| EFNA5 | EPHA3 | 18988627 21071413 23331499 9195962 9245480 9576626 9751130 | stimulation | N/A | SignaLink,SignaLink |
| EPHA3 | CRK | 11870224 18988627 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| EFNA3 | EPHA3 | 23331499 9195962 9267020 | stimulation | N/A | SignaLink |
| EFNA4 | EPHA3 | 23331499 9195962 9576626 | stimulation | N/A | SignaLink |
| EFNB2 | EPHA3 | 23331499 8559144 9195962 | stimulation | N/A | SignaLink |
| EPHA3 | SRC | 23331499 9632142 | stimulation | N/A | SignaLink |
| EPHA3 | FYN | 23331499 9632142 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | EPHA3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | EPHA3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | EPHA3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | EPHA3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | EPHA3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TLE5 | EPHA3 | 20676368 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EFNB2 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA5 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNA5 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB1 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| CRK | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | CRK | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
| SRC | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNA1 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA1 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA3 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| FYN | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | ABL1 | 25361965 | interaction type | N/A | PTMCode2 |
| ABL1 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | RUFY2 | 25361965 | interaction type | N/A | PTMCode2 |
| RUFY2 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | RUFY1 | 25361965 | interaction type | N/A | PTMCode2 |
| RUFY1 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA4 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA2 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | EFNA2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTDSP2 | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | EPHA3 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| CRK | EPHA3 | 11870224 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| SRC | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| SLAMF1 | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| PIM1 | EPHA3 | 14525934 16186805 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CDKN2A | EPHA3 | 17955473 24234451 25348397 | association | pull down,physical interaction | ComPPI,IntAct |
| EFNA4 | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNA5 | EPHA3 | 14525934 25348397 9195962 9245480 9751130 | N/A | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| EFNA1 | EPHA3 | 14525934 25348397 8070404 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| EFNA3 | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| EFNA2 | EPHA3 | 14525934 25348397 9751130 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RUFY1 | EPHA3 | 11877430 14525934 24234451 25348397 | association | two hybrid,coimmunoprecipitation,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD,IntAct |
| EPHA3 | EFNB2 | 14525934 25348397 8559144 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| EPHA3 | RUFY2 | 11877430 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| EPHA3 | ADAM10 | 14525934 16239146 25348397 | N/A | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| EPHA3 | STAT3 | 14525934 16186805 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EPHA3 | TP53 | 14525934 15355990 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| EPHA3 | EFNB1 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | FYN | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | ABL1 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | RBM18 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| EPHA3 | SRPK1 | 23602568 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| EPHA3 | CDKN2A | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | HLA-DRA | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | CEACAM21 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | TMEM231 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | EPHA7 | 22036564 24234451 25348397 | N/A | physical interaction,comigration in sds page | ComPPI,IntAct |
| EPHA3 | LRRIQ1 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | ILKAP | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | DUSP18 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | STYX | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | TPTE | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | MTMR11 | 25348397 | N/A | physical interaction | ComPPI |
| FAM118B | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP21 | EPHA3 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA3 | EPHA3 | 11870224 14525934 | N/A | experimental interaction detection | HPRD |
| H2BC9 | EPHA3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| H1-2 | EPHA3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| EPHA3 | SRC | 27898060 9632142 | stimulant | N/A | OmniPath |
| PTPN1 | EPHA3 | 21135139 27898060 | inhibition | N/A | OmniPath |
| EPHA3 | CRK | 11870224 27898060 | stimulant | N/A | OmniPath |
| EPHA3 | STAT3 | 10918587 11294897 11350938 11940572 12244095 12576423 12626508 14551213 16186805 16497976 17016520 17389395 19901323 27898060 8626374 | N/A | N/A | OmniPath |
| EPHA3 | EFNA5 | 15114347 27898060 9195962 9245480 9751130 | N/A | N/A | OmniPath |
| EFNA5 | EPHA3 | 27898060 9195962 9245480 9330863 9751130 | stimulant | N/A | OmniPath |
| EPHA3 | EFNA2 | 15114347 27898060 9751130 | N/A | N/A | OmniPath |
| EFNA1 | EPHA3 | 15114347 27898060 8070404 9330863 9576626 | stimulant | N/A | OmniPath |
| EPHA3 | EFNA1 | 15114347 27898060 8070404 | N/A | N/A | OmniPath |
| EPHA3 | EFNA4 | 15114347 27898060 | N/A | N/A | OmniPath |
| EFNA4 | EPHA3 | 15114347 27898060 8755474 | N/A | N/A | OmniPath |
| EPHA3 | EFNA3 | 15114347 27898060 | N/A | N/A | OmniPath |
| EFNA3 | EPHA3 | 27898060 9330863 | stimulant | N/A | OmniPath |