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GENE：ERCC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERCC2
FullNmae ERCC excision repair 2, TFIIH core complex helicase subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3434
EnsembleID ENSG00000104884
Uniprot P18074

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERCC2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ERCC2 GO:0000439,GO:0000462,GO:0001666,GO:0001701,GO:0003678,GO:0003684,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005669,GO:0005675,GO:0005675,GO:0005737,GO:0005819,GO:0005829,GO:0006283,GO:0006283,GO:0006289,GO:0006289,GO:0006362,GO:0006366,GO:0006366,GO:0006366,GO:0006915,GO:0006979,GO:0007059,GO:0008340,GO:0009650,GO:0009791,GO:0016887,GO:0021510,GO:0030198,GO:0030282,GO:0030674,GO:0032289,GO:0032508,GO:0035264,GO:0035315,GO:0040016,GO:0043139,GO:0043139,GO:0043249,GO:0045951,GO:0046872,GO:0048009,GO:0048568,GO:0048820,GO:0051539,GO:0060218,GO:0070516,GO:0071425,GO:0071817,GO:0072332,GO:1901990

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERCC2 hsa:2068 path:hsa03022 Basal transcription factors - Homo sapiens (human)
ERCC2 hsa:2068 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERCC2 SQSTM1 23180781 8652557 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ERCC2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ERCC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ERCC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ERCC2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F1 ERCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ERCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A ERCC2 19934262 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB ERCC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA ERCC2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MSH2 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 MSH2 25361965 interaction type N/A PTMCode2
MNAT1 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 MNAT1 25361965 interaction type N/A PTMCode2
ERCC6 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 ERCC6 25361965 interaction type N/A PTMCode2
BLM ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 BLM 25361965 interaction type N/A PTMCode2
CCNH ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 CCNH 25361965 interaction type N/A PTMCode2
TP53 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 TP53 25361965 interaction type N/A PTMCode2
RAD52 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 RAD52 25361965 interaction type N/A PTMCode2
GTF2H5 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 GTF2H5 25361965 interaction type N/A PTMCode2
HSPD1 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 HSPD1 25361965 interaction type N/A PTMCode2
POLD1 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 POLD1 25361965 interaction type N/A PTMCode2
CDK7 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 CDK7 25361965 interaction type N/A PTMCode2
XPA ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 XPA 25361965 interaction type N/A PTMCode2
GTF2H2 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 GTF2H2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CCNH ERCC2 24234451 25348397 26340423 physical association cross-linking study,physical interaction ComPPI,IntAct
CIAO1 ERCC2 24234451 25348397 28178521 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
CIAO2B ERCC2 24234451 25348397 28178521 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ISG15 ERCC2 25348397 N/A physical interaction ComPPI
GTF2A1 ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
GTF2A2 ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
NUDCD3 ERCC2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
ERCC3 ERCC2 14525934 16669699 24234451 25348397 27193682 8652557 physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,electron tomography,in vivo ComPPI,HPRD,IntAct
GTF2B ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
TBP ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
GTF2F2 ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
AR ERCC2 25348397 N/A physical interaction ComPPI
HERC5 ERCC2 25348397 N/A physical interaction ComPPI
GTF2H1 ERCC2 14525934 24234451 25348397 26340423 8652557 9130708 association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NTRK1 ERCC2 25348397 N/A physical interaction ComPPI
STIP1 ERCC2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CACYBP ERCC2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
UHRF2 ERCC2 25348397 N/A physical interaction ComPPI
RAD51 ERCC2 12359753 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
XPO1 ERCC2 25348397 N/A physical interaction ComPPI
MNAT1 ERCC2 25348397 N/A physical interaction ComPPI
SPTA1 ERCC2 25348397 N/A physical interaction ComPPI
EGFR ERCC2 24234451 24780295 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2E2 ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
GTF2E1 ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
TCEA1 ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
GTF2H4 ERCC2 19172752 24234451 25348397 27193682 association,physical association anti bait coimmunoprecipitation,physical interaction,electron tomography ComPPI,IntAct
GTF2F1 ERCC2 24234451 25348397 27193682 physical association physical interaction,electron tomography ComPPI,IntAct
POLR2E ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
CDK7 ERCC2 11445587 14525934 23602568 24234451 25348397 29568061 association experimental interaction detection,pull down,physical interaction,in vitro,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
MMS19 ERCC2 24234451 25348397 28178521 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2H2 ERCC2 14525934 24234451 25348397 27193682 9771713 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,electron tomography,in vitro,in vivo ComPPI,HPRD,IntAct
POLR2A ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
ERCC5 ERCC2 14525934 25348397 8652557 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TRIM25 ERCC2 25348397 N/A physical interaction ComPPI
POLR2K ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2J ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2F ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2C ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2G ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2D ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
CLUH ERCC2 25348397 N/A physical interaction ComPPI
ERCC2 TP53 25348397 N/A physical interaction ComPPI
ERCC2 BIVM 25348397 N/A physical interaction ComPPI
ERCC2 ATF7IP 25348397 N/A physical interaction ComPPI
ERCC2 ERCC6 25348397 N/A physical interaction ComPPI
ERCC2 ERCC6 25348397 N/A physical interaction ComPPI
ERCC2 PIDD1 25348397 N/A physical interaction ComPPI
ERCC2 GTF2H3 24234451 25348397 27193682 physical association coimmunoprecipitation,physical interaction,electron tomography ComPPI,IntAct
ERCC2 RAD52 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
ERCC2 UVSSA 25348397 N/A physical interaction ComPPI
ERCC2 CTPS1 25348397 N/A physical interaction ComPPI
ERCC2 ACAT1 25348397 N/A physical interaction ComPPI
ERCC2 EIF2A 25348397 N/A physical interaction ComPPI
ERCC2 TOPBP1 25348397 N/A physical interaction ComPPI
ERCC2 WDR61 25348397 N/A physical interaction ComPPI
ERCC2 GTF2H5 19172752 24234451 25348397 26496610 27193682 association,physical association anti tag coimmunoprecipitation,physical interaction,electron tomography ComPPI,IntAct
ERCC2 HSF2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
ERCC2 POLR2H 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
ERCC2 POLR2B 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
ERCC2 POLR2I 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
HSCB ERCC2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2H2C ERCC2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ERCC2 CDK1 14525934 8652557 N/A experimental interaction detection HPRD
ERCC2 ERCC2 11062469 11266437 14525934 15220921 N/A experimental interaction detection HPRD
ERCC5 ERCC2 20840796 27898060 8652557 stimulant N/A OmniPath
ERCC2 ERCC3 10024882 15220921 16669699 22678362 22939629 27898060 8152490 8652557 9118947 stimulant N/A OmniPath

Visualization










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