GENE：ERG
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ERG |
| FullNmae | ETS transcription factor ERG |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3446 |
| EnsembleID | ENSG00000157554 |
| Uniprot | P11308 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ERG | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ERG | GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006468,GO:0007165,GO:0030154,GO:0045944,GO:0045944,GO:1990837,GO:1990904 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ERG | hsa:2078 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| ERG | hsa:2078 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ERG | ERG | 23180781 9681824 | physical association | pull down | InnateDB |
| ERG | SPI1 | 23180781 9681824 | physical association | pull down | InnateDB |
| ERG | ETV1 | 23180781 9681824 | physical association | pull down | InnateDB |
| ERG | FLI1 | 23180781 9681824 | physical association | pull down | InnateDB |
| ERG | ETS2 | 23180781 9681824 | physical association | pull down | InnateDB |
| APP | ERG | 21832049 23180781 | physical association | protein array | InnateDB |
| ERG | IGF1R | 23180781 25906745 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ERG | PIM1 | 23180781 25906745 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ERG | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | ERG | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ERG | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | ERG | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ERG | 18971253 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ERG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ERG | ERG | 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KCNH2 | ERG | 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | ERG | 7731694 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | ERG | 7731694 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FLI1 | ERG | 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA3 | ERG | 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LMO2 | ERG | 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LYL1 | ERG | 21536859 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BRCA1 | ERG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR1 | ERG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000032BD73 | ERG | 17344217 | rna interference,inhibition | experimental interaction detection | miRSponge |
| URS00004F4657 | ERG | 23480797 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00004F4657 | ERG | 23480797 25416803 27572146 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000032BD73 | ERG | 17344217 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000065D58 | ERG | 23728339 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00002152A8 | ERG | 23728339 25416803 26653555 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK1 | ERG | 22135298 | phosphorylation | N/A | PhosphoSite |
| CSNK1A1 | ERG | 22135298 | phosphorylation | N/A | PhosphoSite |
| USP14 | ERG | 25361965 | interaction type | N/A | PTMCode2 |
| ERG | USP14 | 25361965 | interaction type | N/A | PTMCode2 |
| SETDB1 | ERG | 25361965 | interaction type | N/A | PTMCode2 |
| ERG | SETDB1 | 25361965 | interaction type | N/A | PTMCode2 |
| PSMD7 | ERG | 25361965 | interaction type | N/A | PTMCode2 |
| ERG | PSMD7 | 25361965 | interaction type | N/A | PTMCode2 |
| ERG | PSMD14 | 25361965 | interaction type | N/A | PTMCode2 |
| PSMD14 | ERG | 25361965 | interaction type | N/A | PTMCode2 |
| ERG | TNF | 25361965 | interaction type | N/A | PTMCode2 |
| TNF | ERG | 25361965 | interaction type | N/A | PTMCode2 |
| TNFRSF1A | ERG | 25361965 | interaction type | N/A | PTMCode2 |
| ERG | TNFRSF1A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDC5L | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPC | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TRIM21 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DDX21 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HSPA8 | ERG | 21183741 21575865 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| NPM1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| PCBP1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TUBB | ERG | 25348397 | N/A | physical interaction | ComPPI |
| ACTB | ERG | 25348397 | N/A | physical interaction | ComPPI |
| RING1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| EZH2 | ERG | 22531786 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ETS2 | ERG | 14525934 25348397 9334186 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| SETDB1 | ERG | 11791185 14525934 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,two hybrid | ComPPI,HPRD,IntAct |
| PRKDC | ERG | 21575865 24234451 25348397 | association | anti bait coimmunoprecipitation,pull down,physical interaction,chromatin immunoprecipitation assay | ComPPI,IntAct |
| JUN | ERG | 11278640 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| AR | ERG | 20478527 22531786 22722839 24234451 25348397 27898060 | association,physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct,OmniPath |
| SF3B1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| NONO | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SFPQ | ERG | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SYN1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| PRPF40A | ERG | 25348397 | N/A | physical interaction | ComPPI |
| PARP1 | ERG | 21575865 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down,physical interaction,chromatin immunoprecipitation assay | ComPPI,IntAct |
| XRCC5 | ERG | 21575865 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| XRN2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPU | ERG | 25348397 | N/A | physical interaction | ComPPI |
| XRCC6 | ERG | 21575865 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NME1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| UBR5 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| CAD | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DDX5 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SPTAN1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| EIF2S1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| CLTC | ERG | 25348397 | N/A | physical interaction | ComPPI |
| LMO2 | ERG | 20676125 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| HUWE1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| RPS18 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| RPLP0 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA2B1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| RPL7A | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HDAC2 | ERG | 22531786 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| HSPA4 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| NOLC1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| POLR2A | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DDX3X | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPUL1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| NEDD4 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPF | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPH1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SPOP | ERG | 25348397 | N/A | physical interaction | ComPPI |
| ILF2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPD | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SNRNP200 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| BRD4 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| STUB1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| PUF60 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| RCC2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DNAJA1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPAB | ERG | 25348397 | N/A | physical interaction | ComPPI |
| UHRF1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TRIM33 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TRIP12 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPM | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TOP1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SF3B3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TOP2B | ERG | 25348397 | N/A | physical interaction | ComPPI |
| SF3B2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HSPD1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| BRD3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| ILF3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPH3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| EEF1A2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| ATP5F1A | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DKC1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| FBL | ERG | 25348397 | N/A | physical interaction | ComPPI |
| NUMA1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| PRPF8 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DNAJA2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HERC2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| UBR4 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| APP | ERG | 25348397 | N/A | physical interaction | ComPPI |
| XRCC4 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| MATR3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| TPM1 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HDAC1 | ERG | 22531786 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| HERC2P3 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| DDX23 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| USP9X | ERG | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPDL | ERG | 25348397 | N/A | physical interaction | ComPPI |
| NCL | ERG | 25348397 | N/A | physical interaction | ComPPI |
| KDM4A | ERG | 24234451 25348397 27109047 | physical association | anti tag coimmunoprecipitation,pull down | ComPPI,IntAct |
| RPLP0P6 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| ERG | DNAJA4 | 25348397 | N/A | physical interaction | ComPPI |
| ERG | ADAR | 25348397 | N/A | physical interaction | ComPPI |
| ERG | HNRNPUL2 | 25348397 | N/A | physical interaction | ComPPI |
| ERG | LANCL1 | 25348397 | N/A | physical interaction | ComPPI |
| ERG | LRRK2 | 24234451 24947832 25348397 | N/A | protein array | ComPPI,IntAct |
| ERG | ERG | 14525934 9681824 | N/A | experimental interaction detection | HPRD |
| SPI1 | ERG | 14525934 9681824 | N/A | experimental interaction detection | HPRD |
| FLI1 | ERG | 14525934 9681824 | N/A | experimental interaction detection | HPRD |
| ETV1 | ERG | 14525934 9681824 | N/A | experimental interaction detection | HPRD |
| CSNK1A1 | ERG | 26344095 26344096 27898060 | N/A | N/A | OmniPath |
| MAPK1 | ERG | 23918819 27898060 | N/A | N/A | OmniPath |