GENE：FCGR2B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FCGR2B |
| FullNmae | Fc gamma receptor IIb |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3618 |
| EnsembleID | ENSG00000072694 |
| Uniprot | P31994 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FCGR2B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FCGR2B | GO:0001540,GO:0001540,GO:0001811,GO:0001814,GO:0001818,GO:0002266,GO:0002313,GO:0002316,GO:0002436,GO:0002605,GO:0002622,GO:0002638,GO:0002819,GO:0002865,GO:0002922,GO:0002924,GO:0004888,GO:0005515,GO:0005886,GO:0005886,GO:0006898,GO:0006911,GO:0006952,GO:0006954,GO:0006955,GO:0007165,GO:0007166,GO:0009617,GO:0009897,GO:0010469,GO:0016064,GO:0019772,GO:0019864,GO:0019886,GO:0021549,GO:0030889,GO:0032693,GO:0038096,GO:0043031,GO:0043197,GO:0043318,GO:0044297,GO:0044877,GO:0045088,GO:0046330,GO:0050765,GO:0050766,GO:0050776,GO:0050777,GO:0050859,GO:0050869,GO:0071219,GO:0090264,GO:1902564,GO:1902950,GO:1903381,GO:1904646,GO:1905898,GO:2001199 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FCGR2B | hsa:2213 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| FCGR2B | hsa:2213 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| FCGR2B | hsa:2213 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| FCGR2B | hsa:2213 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| FCGR2B | hsa:2213 | path:hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| FCGR2B | hsa:2213 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| FCGR2B | hsa:2213 | path:hsa05162 | Measles - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CRK | FCGR2B | 20005715 | interaction type | N/A | PSP,SignaLink |
| GRB2 | FCGR2B | 20005715 | interaction type | N/A | PSP |
| LY6E | FCGR2B | 20005715 | interaction type | N/A | PSP |
| NCK1 | FCGR2B | 20005715 | interaction type | N/A | PSP,SignaLink |
| SHC1 | FCGR2B | 20005715 | interaction type | N/A | PSP |
| SHC1 | FCGR2B | 20005715 20005715 21071413 8940017 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | FCGR2B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | FCGR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | FCGR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FCGR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FCGR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | FCGR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | FCGR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA4 | FCGR2B | 15153544 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| YY1 | FCGR2B | 15153544 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FYN | FCGR2B | 22135298 | phosphorylation | N/A | PhosphoSite |
| BLK | FCGR2B | 22135298 | phosphorylation | N/A | PhosphoSite |
| LYN | FCGR2B | 22135298 | phosphorylation | N/A | PhosphoSite |
| CRP | FCGR2B | 25361965 | interaction type | N/A | PTMCode2 |
| FCGR2B | CRP | 25361965 | interaction type | N/A | PTMCode2 |
| CRK | FCGR2B | 25361965 | interaction type | N/A | PTMCode2 |
| FCGR2B | CRK | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LGALS3 | FCGR2B | 24072822 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| IGHG1 | FCGR2B | 11567028 24234451 25348397 27898060 | N/A | isothermal titration calorimetry,surface plasmon resonance | ComPPI,IntAct,OmniPath |
| PTPN6 | FCGR2B | 14525934 24234451 25348397 7716523 8577729 9148918 9603468 | association,physical association | affinity chromatography technology,experimental interaction detection,proteinchip(r,pull down,in vitro,in vivo | ComPPI,HPRD,IntAct |
| CRK | FCGR2B | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| MAPK1 | FCGR2B | 14525934 15081531 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| LYN | FCGR2B | 10382761 14525934 24234451 25348397 8756631 | association | experimental interaction detection,pull down,in vitro | ComPPI,HPRD,IntAct |
| PTPN11 | FCGR2B | 10382761 24234451 25348397 | association | pull down,physical interaction | ComPPI,IntAct |
| SRC | FCGR2B | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| INPP5D | FCGR2B | 10382761 14525934 24234451 24642916 25348397 9148918 | association,physical association | affinity chromatography technology,experimental interaction detection,pull down,surface plasmon resonance,in vitro | ComPPI,HPRD,IntAct |
| SHC1 | FCGR2B | 10382761 24234451 25348397 | association | pull down,physical interaction | ComPPI,IntAct |
| NCK1 | FCGR2B | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| MAPK3 | FCGR2B | 14525934 15081531 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| FCGR2B | INPPL1 | 10789675 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| FCGR2B | LY6E | 11576217 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| FCGR2B | CRP | 12471137 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| FCGR2B | ERG28 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| FCGR2B | APCS | 11359830 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| FCGR2B | FCGR2A | 25348397 | N/A | physical interaction | ComPPI |
| FCGR2B | MARS2 | 25348397 | N/A | physical interaction | ComPPI |
| FCGR2B | GSK3A | 25348397 | N/A | physical interaction | ComPPI |
| FCGR2B | PLCG1 | 17474147 24234451 25348397 | physical association | fluorescence technology,peptide array | ComPPI,IntAct |
| FCGR2B | FYN | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| FCGR2B | GRB2 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| BLK | FCGR2B | 14525934 25348397 8756631 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TRIM21 | FCGR2B | 18420815 27898060 | N/A | N/A | OmniPath |
| SRC | FCGR2B | 17474147 27898060 8756631 | stimulant | N/A | OmniPath |
| LYN | FCGR2B | 10382761 27898060 8756631 | stimulant | N/A | OmniPath |
| BLK | FCGR2B | 27898060 8756631 | stimulant | N/A | OmniPath |