Gene Information gene info

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GENE：FGF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FGF1
FullNmae fibroblast growth factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3665
EnsembleID ENSG00000113578
Uniprot P05230

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FGF1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FGF1 GO:0001525,GO:0001759,GO:0005104,GO:0005104,GO:0005104,GO:0005178,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005938,GO:0007165,GO:0008083,GO:0008083,GO:0008201,GO:0008201,GO:0008284,GO:0008284,GO:0008543,GO:0008543,GO:0008543,GO:0008543,GO:0008543,GO:0009653,GO:0009887,GO:0010595,GO:0010595,GO:0010628,GO:0030154,GO:0030324,GO:0030335,GO:0030335,GO:0030544,GO:0031012,GO:0032148,GO:0034605,GO:0042060,GO:0042060,GO:0043406,GO:0043406,GO:0044548,GO:0045542,GO:0045766,GO:0045944,GO:0045944,GO:0050673,GO:0050679,GO:0051781,GO:0060681,GO:0070374,GO:0072163,GO:1901509,GO:1902533,GO:1903672,GO:2000347,GO:2000544

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FGF1 hsa:2246 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FGF1 hsa:2246 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
FGF1 hsa:2246 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
FGF1 hsa:2246 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
FGF1 hsa:2246 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
FGF1 hsa:2246 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
FGF1 hsa:2246 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
FGF1 hsa:2246 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FGF1 hsa:2246 path:hsa05218 Melanoma - Homo sapiens (human)
FGF1 hsa:2246 path:hsa05224 Breast cancer - Homo sapiens (human)
FGF1 hsa:2246 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FGF1 HGF 14517404 16272825 16682805 26183471 26192618 9242465 interaction type N/A ACSN
FGF1 FGFR1 11030354 14517404 16272825 16682805 21071413 23331499 26183471 26192618 8576175 9242465 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
FGF1 ETS1 14517404 16272825 16682805 21081489 26183471 26192618 9242465 interaction type N/A ACSN
FGF1 FGFR2 10618369 21071413 23331499 8576175 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR FGF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 FGF1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 FGF1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 FGF1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FGF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARG FGF1 22522926 trascriptional regulation,stimulation inferred by curator TFlink
RFX1 FGF1 20189986 22415835 trascriptional regulation,stimulation inferred by curator TFlink
RFX2 FGF1 22415835 trascriptional regulation,stimulation inferred by curator TFlink
RFX3 FGF1 22415835 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 FGF1 14673954 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 FGF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AF45F FGF1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004A9320 FGF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000A939F FGF1 25416803 26183397 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
VBP1 FGF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
S100A13 FGF1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
FGFR2 FGF1 10618369 24234451 25241761 25348397 physical association affinity chromatography technology,cross-linking study,molecular sieving,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
SDC2 FGF1 25348397 N/A physical interaction ComPPI
HMG20A FGF1 25348397 N/A physical interaction ComPPI
CSNK2A1 FGF1 12145206 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SDC4 FGF1 25348397 N/A physical interaction ComPPI
SYT1 FGF1 11432880 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SRPK1 FGF1 23602568 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CSNK2A2 FGF1 12145206 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FGFR3 FGF1 10574949 14525934 14732692 24234451 25348397 N/A coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
FGFR1 FGF1 10830168 18441324 24234451 25241761 25348397 physical association cross-linking study,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay,surface plasmon resonance array ComPPI,IntAct
TGFBR3 FGF1 25348397 N/A physical interaction ComPPI
HSPA9 FGF1 10510314 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
GPC1 FGF1 25348397 N/A physical interaction ComPPI
RCOR1 FGF1 25348397 N/A physical interaction ComPPI
HSPG2 FGF1 24234451 24509440 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
KDM1A FGF1 25348397 N/A physical interaction ComPPI
FGFR4 FGF1 10336501 10736564 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,biochemical,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CSNK2B FGF1 12145206 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FGF1 RPS2 14525934 16263090 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
FGF1 FGFBP1 11509569 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FGF1 FIBP 14525934 25348397 27898060 9806903 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
FGF1 GSE1 25348397 N/A physical interaction ComPPI
FGF1 EGFLAM 25348397 N/A physical interaction ComPPI
FGF1 RCOR3 25348397 N/A physical interaction ComPPI
FGF1 GPC6 25348397 N/A physical interaction ComPPI
FGF1 CLDN10 25348397 N/A physical interaction ComPPI
FGF1 GPC3 25348397 N/A physical interaction ComPPI
FGF1 FGF1 11069186 11432880 14525934 24234451 9655399 N/A experimental interaction detection,comigration in sds page HPRD,IntAct
FGF1 NRP1 14525934 15695515 N/A experimental interaction detection HPRD
FGF1 FGFR1 10336501 10830168 11030354 11032250 1722683 18441324 18940940 22244757 25241761 27898060 7730326 8576175 8663044 stimulant N/A OmniPath
FGF1 FGFR3 10574949 14732692 22244757 22298955 27898060 8576175 9045692 stimulant N/A OmniPath
FGF1 FGFR2 10339576 10618369 11069186 14732692 25241761 27898060 8576175 8663044 stimulant N/A OmniPath
FGF1 FGFR4 10336501 10736564 1385111 25241761 27898060 7680645 stimulant N/A OmniPath

Visualization










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